Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.05a
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- Pages.94-94
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- 2002
BETA-AMYLOID INDUCES OXIDATIVE AND/OR NITRATIVE PC12 CELL DEATH: POSSIBLE INVOLVEMENT OF INFLAMMATORY CASCADES
- Jang, Jung-Hee (College of Pharmacy, Seoul National University) ;
- Surh, Young-Joon (College of Pharmacy, Seoul National University)
- Published : 2002.05.01
Abstract
Oxidative stress induced by reactive oxygen and/or nitrogen species has been considered as a major cause of cellular injuries in a variety of neurodegenerative disorders including Alzheimer's disease (AD). Inflammatory as well as oxidative tissue damage has been implicated in pathophysiology of AD, and non-steroidal anti-inflammatory drugs have been reported to have beneficial effects in the treatment or prevention of AD.(omitted)