Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.05a
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- Pages.92-92
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- 2002
POTENT INHIBITION OF HUMAN CYTOCHROME P450 1 ENZYMES BY DIMETHOXYPHENYL VINYL THIOPHENE.
- Lee, Sangk wang (College of Pharmacy, Chungang University) ;
- Kim, Sanghee (Natural Products Research Institute, Seoul National University) ;
- Kim, Mie young (College of Pharmacy, Chungang University) ;
- Chun, Young-Jin (College of Pharmacy, Chungang University)
- Published : 2002.05.01
Abstract
Recently we have reported that various hydroxystilbenes show strong inhibition of human P450 1 activity. A series of synthetic trans-stilbene derivatives were prepared and their inhibitory potentials were evaluated with the bacterial membrane of recombinant human P450 1A1, 1A2 or 1B1 coexpressed with human P450/NADPH-450 reductase to find new candidates for cancer chemoprevention.(omitted)
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