• Title/Summary/Keyword: Dimethoxyphenyl vinly thiophene

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POTENT INHIBITION OF HUMAN CYTOCHROME P450 1 ENZYMES BY DIMETHOXYPHENYL VINYL THIOPHENE.

  • Lee, Sangk wang;Kim, Sanghee;Kim, Mie young;Chun, Young-Jin
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2002.05a
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    • pp.92-92
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    • 2002
  • Recently we have reported that various hydroxystilbenes show strong inhibition of human P450 1 activity. A series of synthetic trans-stilbene derivatives were prepared and their inhibitory potentials were evaluated with the bacterial membrane of recombinant human P450 1A1, 1A2 or 1B1 coexpressed with human P450/NADPH-450 reductase to find new candidates for cancer chemoprevention.(omitted)

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