Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.05a
- /
- Pages.84-84
- /
- 2002
GENE-SPECIFIC OXIDATIVE DNA DAMAGE IN HELICOBACTER PYLORI INFECTED HUMAN GASTRIC MUCOSA
- Jinhee Chol (Department of Pharmacology, Seoul National University, College of Medicine) ;
- Yoon, Sun-Hee (Department of Pharmacology, Seoul National University, College of Medicine) ;
- Kim, Ja-Eun (Department of Pharmacology, Seoul National University, College of Medicine) ;
- Rhee, Kwang-Ho (Department of Microbiology, Gyeongsang University, College of Medicine) ;
- Youn, Hee-Sang (Pediatrics, Gyeongsang University, College of Medicine) ;
- Chung, Myung-Hee (Department of Pharmacology, Seoul National University, College of Medicine)
- Published : 2002.05.01
Abstract
Abstract To study the status of oxidative DNA damage in Helicobacter pylori infection in more details, gene-specific oxidative DNA damage was investigated by examining oxidative DNA damage to individual genes. This was done by determining the loss of PCR product of a targeted gene before and after gastric mucosal DNA was treated with 8-hydroxyguanine glycosylase, which cleaves DNA at the 8-hydroxyguanine residues.(omitted)
Keywords