Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.05a
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- Pages.74-74
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- 2002
CHEMOPREVENTIVE EFFECTS OF ETHYL 3-(4'-GERANYLOXY-3-METHOXYPHENYL)-2-PROPENOATE AND FERULIC ACID ON MOUSE COLON CARCINOGENESIS
- Han, Beom-Seok (Division of General Toxicology, National Institute of Toxicological Research) ;
- Shin, Dong-Whan (Division of General Toxicology, National Institute of Toxicological Research) ;
- Yum, Young-Na (Division of General Toxicology, National Institute of Toxicological Research) ;
- Cho, Jeong-Sik (Division of General Toxicology, National Institute of Toxicological Research) ;
- Yang, Ki-Wha (Division of General Toxicology, National Institute of Toxicological Research) ;
- Nobuo Takasuka (Department of Experimental Pathology and Chemotherpy, National Cancer Center Research Institute) ;
- Tetsuyuki Takahashi (Department of Experimental Pathology and Chemotherpy, National Cancer Center Research Institute) ;
- Hiroyuki Tsuda (Department of Experimental Pathology and Chemotherpy, National Cancer Center Research Institute)
- Published : 2002.05.01
Abstract
Ethyl 3-(4'-geranyloxy-3-methoxyphenyl)-2-propenoate (EGMP) and ferulic acid (FA) have been shown to inhibit development of aberrant crypt foci (ACF) in the azoxymethane (AOM)-treated rat colon. In the present study, inhibitory effects of EGMP and FA on the post-initiation stage of AOM-induced colon carcinogenesis were studied in male ddY mice.(omitted)