ROLE OF METABOLISM BY FLAVIN-CONTAINING MONOOXYGENASE IN THIOACETAMIDE-INDUCED IMMUNOSUPPRESSION

  • Woo S. Koh (Korea Institute of Toxicology) ;
  • Lee, Jeong W. (Korea Institute of Toxicology) ;
  • Tae C. Jeong (College of Pharmacy, Yeungnam University)
  • Published : 2002.05.01

Abstract

Thioacetamide has been known to cause immune suppression. The object of the present study is to investigate the role of metabolic activation by flavin- containing monooxygenases (FMO) in thioacetamide-induced immune response. To determine whether the metabolites of thioacetamide produced by FMO causes the immunosuppression, methimazole (MMI), an FMO inhibitor, was used to block the FMO pathway.(omitted)

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