Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Coordination of Pancreatic $HCO_3^-$ Secretion by Protein-Protein Interaction between CFTR and Luminal NHE

  • Wooin Ahn (Department of Pharmacology, Yonsei University College of Medicine) ;
  • Kim, Kyung-Hwan (Department of Pharmacology, Yonsei University College of Medicin) ;
  • Lee, Jin-Ah (Department of Pharmacology, Yonsei University College of Medicin) ;
  • Kim, Joo-Young (Department of Pharmacology, Yonsei University College of Medicin) ;
  • Park, Joo-Young (Department of Physiology and University of Texas Southwestern Medical Cente) ;
  • Shmuel Muallem (Department of Physiology and University of Texas Southwestern Medical Cente) ;
  • Lee, Min-Goo (Department of Pharmacology, Yonsei University College of Medicine)
  • Published : 2001.06.01
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Abstract

Increasing evidence suggests that protein-protein interaction is essential in many biological processes including epithelial transport. In this report, we present the significance of protein interactions to HCO$_3$$^{-10}$ secretion in pancreatic duct cells. In pancreatic ducts HCO$_3$$^{-10}$ secretion is mediated by CFTR-activated luminal CUHCO$_3$$^{-10}$ exchange activity and HCO$_3$$^{-10}$ absorption is achieved by Na$^{＋}$-dependent mechanism including NHE3.(omitted)

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