한국생물물리학회:학술대회논문집 (Proceedings of the Korean Biophysical Society Conference)

한국생물물리학회 (The Korean Biophysical Society)
권호 표지

Large pKa Perturbations at an Enzyme Active Site, a Mechanistic Basis for Catalytic Power of Many Enzymes

  • Oh, Byung-Ha (Division of Molecular and Life Science, Pohang University of Science and Technology) ;
  • Ha, Nam-Chul (Division of Molecular and Life Science, Pohang University of Science and Technolog) ;
  • Kim, Min-Sung (Division of Molecular and Life Science, Pohang University of Science and Technology)
  • 발행 : 2001.06.01
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초록

Bacterial Δ$\^$5/-3-ketosteroid isomerase (KSI) is one of the most proficient enzymes catalyzing the isomerization of a variety of Δ$\^$5/-ketosteroids to Δ$^4$-ketosteroids at a diffusion-controlled rate. Because of the simplicity of the reaction, the enzyme mechanism has been intensively studied as a prototype to understand enzyme-catalyzed C-H bond cleavage.(omitted)

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