한국생물물리학회:학술대회논문집 (Proceedings of the Korean Biophysical Society Conference)
- 한국생물물리학회 2001년도 학술 발표회 진행표 및 논문초록
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- Pages.32-32
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- 2001
Crystal Structure of Helicobacter pylori Urease Reveals an Exquisite Molecular Design Suitable for Surviving Gastric Acid
- Ha, Nam-Chul (National Creative Research Initiative Center for Biomolecular Recognition, Department of Life Science, and Division of Molecular and Life Science, Pohang University of Science and Technology) ;
- Oh, Byung-Ha (National Creative Research Initiative Center for Biomolecular Recognition, Department of Life Science, and Division of Molecular and Life Science, Pohang University of Science and Technology)
- 발행 : 2001.06.01
초록
Helicobacter pylori (Hp), an important etiologic agent in a variety of gastroduodenal diseases, produces a large amount of urease, which is believed to neutralize gastric acid by producing ammonia for the survival of the bacteria. Up to 30% of the enzyme is associated with the surface of intact cells by lysis of neighboring bacteria. However, the role of the external enzyme has been a subject of controversy, because the enzyme is irreversibly inactivated below pH 5.(omitted)
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