한국생물물리학회:학술대회논문집 (Proceedings of the Korean Biophysical Society Conference)

한국생물물리학회 (The Korean Biophysical Society)
권호 표지

Functional Role of the Native Strain that is Distributed throughout an <$\alpha_1$-antitrypsin

  • Seo, Eun-Joo (National Creative Research Initiatives, Protein Strain Research Center, Institute of Science and Technology) ;
  • Yu, Myeong-Hee (National Creative Research Initiatives, Protein Strain Research Center, Institute of Science and Technology)
  • 발행 : 2001.06.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The native strain of serpins (serine protease inhibitors) has been recognized as a mechanism of biological regulation. Indeed, some stabilizing single residue mutations of human $\alpha$$_1$-antitrypsin, a prototype serpin, relieved local strain and caused the loss of inhibitory activity. The native strain of $\alpha$$_1$-antitrypsin is distributed throughout the whole molecule, but the strain that regulates the function directly is highly localized in the regions that appear to be mobilized during complex formation with a target protease.(omitted)

키워드