Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)
- 2001.06a
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- Pages.30-30
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- 2001
Design, Syntheses, and Conformational Study of Angiogenesis Inhibitors
- Park, Kyoungsoo (Department of Chemistry, Konkuk University) ;
- Dongha Baek (Department of Chemistry, Konkuk University) ;
- Dongyeol Lim (Applied Chemistry, Sejong University) ;
- Park, Sang-Don (Applied Chemistry, Sejong University) ;
- Kim, Min-Young (AngioLab, Inc) ;
- Park, Yong-Sun (Department of Chemistry, Konkuk University) ;
- Kim, Yangmee (Department of Chemistry, Konkuk University)
- Published : 2001.06.01
Abstract
Since anti-angiogenesis could lead to the suppression of tumor growth, angiogenesis inhibitors have received particular attention for their therapeutic potential. In this study, two angiogenic inhibitors using the bioactive sequence from the kringle 5, AK1(KLYDY), AK2(KLWDF) were designed and synthesized. We have investigated their solution structures using NMR spectroscopy and their activities as angiogenesis inhibitors.(omitted)
Keywords