Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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ASSESSMENT OF LOCAL LYMPH NODE ASSAY AS AN ALTERNATIVE METHOD FOR SKIN SENSITIZATION POTENTIAL

  • Hwang, In-Chang (Immunotoxicology Division, National Institute of Toxicology Research, Korea Food and Drug Administration) ;
  • Kim, Hyung-Soo (Immunotoxicology Division, National Institute of Toxicology Research, Korea Food and Drug Administratio) ;
  • Dong, Mi-Sook (Immunotoxicology Division, National Institute of Toxicology Research, Korea Food and Drug Administratio) ;
  • Park, Jae-Hyun (Immunotoxicology Division, National Institute of Toxicology Research, Korea Food and Drug Administratio) ;
  • Lee, Jong-Kwon (Immunotoxicology Division, National Institute of Toxicology Research, Korea Food and Drug Administratio) ;
  • Oh, Hye-Young (Immunotoxicology Division, National Institute of Toxicology Research, Korea Food and Drug Administratio) ;
  • Park, Young-In (Immunotoxicology Division, National Institute of Toxicology Research, Korea Food and Drug Administration)
  • Published : 2001.10.01
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Abstract

Preclinical test methods for allergenic potential chemicals has been widely used to assess human risks and has been developed. Recently, the murine local lymph node assay (LLNA) has been proposed as a prospective method to identify contact allergens and to replace conventional the guinea pig maximization test (GPMT). The objective of this study was to establish LLNA and to evaluate allergenicity of chemicals by LLNA. (omitted)

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