GENETIC POLYMORPHISMS AND CHROMOSOMAL INSTABILITY TO LUNG CANCER IN THE KOREAN POPULATIONS

  • Eom, Mi-Ok (Division of Genetic Toxicology, National Institute of Toxicological Research, Korea Food and drug Administration) ;
  • Oh, Hye-Young (Division of Genetic Toxicology, National Institute of Toxicological Research, Korea Food and drug Administratio) ;
  • Min, Soo-Jin (Division of Genetic Toxicology, National Institute of Toxicological Research, Korea Food and drug Administratio) ;
  • Kim, Jong-Won (Division of Genetic Toxicology, National Institute of Toxicological Research, Korea Food and drug Administratio) ;
  • Park, Mi-Sun (Division of Genetic Toxicology, National Institute of Toxicological Research, Korea Food and drug Administratio) ;
  • Han, Eui-Sik (Division of Genetic Toxicology, National Institute of Toxicological Research, Korea Food and drug Administratio) ;
  • Jung, Hai-Kwan (Division of Genetic Toxicology, National Institute of Toxicological Research, Korea Food and drug Administratio) ;
  • Jong, Won-Sang (College of Medicine, Hanyang University) ;
  • Kim, Ok-Hee (Division of Genetic Toxicology, National Institute of Toxicological Research, Korea Food and drug Administration)
  • Published : 2001.10.01

Abstract

Although the incidence rates of gastric cancer and liver cancer, the most common cancers in Korea, are tending decrease, lung cancer is on the increase every year as cause of cancer death as well as incidence rate in Korea. And cigarette smoke is believed to be responsible for 90% of lung cancer. Many investigators have reported an association between genetic polymorphism of cytochromes P-450 (CYPs) or glutathoine S-transferase (GSTs) and susceptibility to lung cancer.(omitted)

Keywords