Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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ALTERATIONS IN HEPATIC GSH SYNTHESIS INDUCED BY PROPARGYLGLYCINE IN MICE

  • Kim, Sang K. (College of Pharmacy, Seoul National University) ;
  • Kim, Sung Y. (College of Pharmacy, Seoul National University) ;
  • Jung M. Seo (College of Pharmacy, Seoul National University) ;
  • Kim, Young C. (College of Pharmacy, Seoul National University)
  • Published : 2001.10.01
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Abstract

Effects of propargylglycine (PPG) treatment on the hepatic glutathione (GSH) synthesis were examined in adult male ICR mice. Administration of PPG (200 mole/kg, ip) to mice resulted in a complete inhibition of the hepatic cystathionine ${\gamma}$ -lyase (C ${\gamma}$ L) activity measured in cytosol fraction for 40 hr after the treatment. A single injection of PPG rapidly reduced the hepatic GSH levels, which appeared to be sustained at least for 40 hr.(omitted)

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