Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.165-165
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- 2001
EFFECT OF BETAINE OR TAURINE PRETREATMENT ON LIPOPOLYSACCHARIDE-INDUCED HEPATOTOXICITY IN RATS
- Kim, Sang K. (College of Pharmacy, Seoul National University) ;
- Young S. Jung (College of Pharmacy, Seoul National University) ;
- Yu R. Chae (College of Pharmacy, Seoul National University) ;
- Kim, Young C. (College of Pharmacy, Seoul National University)
- Published : 2001.10.01
Abstract
The effects of betaine or taurine on hepatotoxicity induced by lipopolysaccharide (LPS) were examined in adult male SD rats. Rats were provided with drinking water containing either 1 % betaine or taurine for 2 weeks prior to challenge with LPS (5 mg/kg, iv). Supplement of betaine or taurine protected the animals from induction of LPS hepatotoxicity as measured by changes in aspartate aminotrassferase (AST), alanine aminotransferase (ALT) activities and total bilirubin levels in serum, and hepatic glutathione contents.(omitted)
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