Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.154-155
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- 2001
CELECOXIB ATTENUATES ET-18-O-CH3-INDUCED APOPTOSIS IN H-ras TRANSFORMED HUMAN BREAST EPITHELIAL CELLS
- Na, Hye-Kyung (College of Pharmacy, Seoul National University) ;
- Surh, Young-Joon (College of Pharmacy, Seoul National University)
- Published : 2001.10.01
Abstract
Cyclooxygenase-2 (COX-2) is an inducible enzyme expressed in response to a variety of proinflammatory agents and cytokines. COX-2 expression has been shown to be elevated in several different types of human cancer. The presence of oncogenic ras has been associated with constitutive induction of COX-2 in certain H-ras transformed cells, and COX-2 overexpression confers resistance to apoptosis.(omitted)
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