Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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SUPPRESSION OF HUMAN PROSTATE CANCER CELL GROWTH BY $\beta$-LAPACHONE VIA INHIBITION OF pRB PHOSPHORYLATION AND INDUCTION OF Cdk INHIBITOR $p21^{WAF1/CIP1}$

  • Park, Yung-Hyun (Department of Biochemistry, College of Oriental Medicine, Dong-Eui University and Research Center for Oriental Medicine) ;
  • Kang, Ho-Sung (Department of Molecular Biology, College of Natural Sciences, Pusan National University) ;
  • Yoo, Mi-Ae (Department of Molecular Biology, College of Natural Sciences, Pusan National University)
  • Published : 2001.10.01
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Abstract

$\beta$ -lapachone, the product of a tree (Tabebuia avellanedae) from South America, is known to exhibit various pharmacologic properties, the mechanisms of which are poorly understood. The aim of the present study was to further elucidate the possible mechanisms by which $\beta$-lapachone exerts its anti-proliferative action in cultured human prostate cancer cells.(omitted)

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