Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.130-130
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- 2001
INHIBITION OF INDUCIBLE NITRIC OXIDE SYNTHASE EXPRESSION BY SILYMARIN IN LPS-STIMULATED MACROPHAGES
- Kang, Jong-Soon (Department of Biological Sciences, Korea Advanced Institute of Science and Technology) ;
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Jeon, Young-Jin
(Department of Pharmacology, Chosun University School of Medicin)
;
- Yang, Kyu-Hwan (Department of Biological Sciences, Korea Advanced Institute of Science and Technolog) ;
- Kim, Hwan-Mook (Biopotency Evaluation Laboratory, Korea Research Institute of Bioscience and Biotechnology)
- Published : 2001.10.01
Abstract
Silymarin, a polyphenolic flavonoid antiodant, has been shown to have anti-inflammatory, hepatoprotective, and anticarcinogenic effects. In the present study, we report the inhibitory effect of silymarin on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) mRNA expression in macrophages. In vivo administration of silymarin attenuated NO production of peritoneal macrophages in lipopolysaccharide (LPS)-treated mice.(omitted)
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