SEARCH FOR DIETARY CONSTITUENTS WHICH PROTECT TOWARDS HETEROCYCLIC AROMATIC AMINES (HAs)

  • Knasmuller, Siegfried (Instiute of Cancer Research, University of Vienna) ;
  • Steinkellner, Hans (Instiute National de la Recherche Agronomique, Jouy en Josa) ;
  • Zsivkovits, Markus (Instiute National de la Recherche Agronomique, Jouy en Josa) ;
  • Uhl, Maria (Instiute National de la Recherche Agronomique, Jouy en Josa) ;
  • Loste, Evelyn (Instiute National de la Recherche Agronomique, Jouy en Josa) ;
  • Kassie, Fekadu (Instiute National de la Recherche Agronomique, Jouy en Josas)
  • Published : 2001.10.01

Abstract

The increasing evidence for the involvement of food borne HAs in the aetiology of human cancer has stimulated intense efforts to identify dietary constituents which protect against these compounds. About 280 articles on this topic have been published in the last 20 years, most of them were antimutagenicity studies with indicator cells that require addition of exogenous activation mix. The experimental models do not adequately reflect protective mechanisms that are active in vivo and may give misleading results.(omitted)

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