Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.41-42
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- 2001
MECHANISM OF CHEMOPREVENTION OF CARCINOGENIC HETEROCYCLIC AMINES BY TEA POLYPHENOLS AND COFFEE LIPIDS
- Fred F. Kadlubar (National Center for Toxicological Research) ;
- Lin, Dong-xin (Chinese Academy of Medical Sciences ＆ Beijing Union Medical University) ;
- Daniel A. Casciano (National Center for Toxicological Research)
- Published : 2001.10.01
Abstract
The chemopreventive effect of tea against 2-amino-l-methyl-6-phenylimidazo［4, 5-b ］pyridine (PhIP)-DNA adduct formation and its mechanism were studied. Rats were exposed to freshly prepared aqueous extracts of green tea (3% w/v) as the sole source of drinking water for 10 days prior to administration with a single dose of PhIP (10 mg/kg body wt) by oral gavage. PhIP-DNA adducts in the liver, colon, heart, and lung were measured using the
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