Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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8-HYDROXYGUANINE; A MEDIATOR OF OXIDATIVE STRESS-INDUCED CYTOTOXICITY AND A DETECTOR OF GENE-SPECIFIC OXIDATIVE DAMAGE

  • Hyun, Jin-Won (Department of Pharmacology, Seoul National University College of Medicine) ;
  • Park, Jinhee (Department of Pharmacology, Seoul National University College of Medicin) ;
  • Kim, Ja-Eun (Department of Pharmacology, Seoul National University College of Medicin) ;
  • Chung, Myung-Hee (Department of Pharmacology, Seoul National University College of Medicine)
  • Published : 2001.10.01
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Abstract

8-Hydroxyguanine(oh$\^$8/Gua), an oxidative DNA adduct is a most easily and abundantly formed base modification. What we have known about oh$\^$8/Gua so far is that this DNA adduct mediates the mutagenesis and it is used as a useful marker of oxidative DNA damage. We found additional evidence and here present them: 1) oh$\^$8/Gua in DNA can trigger cell death by inducing cell cycle arrest and apoptosis and 2) it can be used to assess the oxidative damage of each individual gene.(omitted)

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