Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.05a
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- Pages.132-132
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- 2001
THE ROLES OF ATP AND CALCIUM IN MORPHOLOGY CHANGES AND CYTOTOXICITY INDUCED BY BENZOQUINONE IN PLATELETS
- Lee, Sun-Ku (College of Pharmacy, Seoul National University) ;
- Chung, Seung-Min (College of Pharmacy, Seoul National University) ;
- Lee, Moo-Yeol (College of Pharmacy, Seoul National University) ;
- Chung, Jin-Ho (College of Pharmacy, Seoul National University)
- Published : 2001.05.01
Abstract
To understand mechanism of benzoquinone-induced cytotoxicity, the roles of ATP and calcium in platelet toxicity and morphology changes was investigated. Using scanning electron microscopy, morphological changes to platelets following l,4-benzoquinone exposure consisted of membrane blebbing at 5 min which was significantly different from shape changes (pseudopod formation) observed in response to physiological agonists.(omitted)
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