Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

THE ACUTE TOXICITY TEST OF A NOVEL MICELLAR SOLUBILIZER FOR USE WITH INJECTABLE ANTICANCER AGENTS

  • Kim, Y.W. (College of Pharmacy, Ewha Womans University) ;
  • Min, K.N. (College of Pharmacy, Ewha Womans University) ;
  • Pan, S.R. (College of Pharmacy, Ewha Womans University) ;
  • Ok, K.E. (College of Pharmacy, Ewha Womans University) ;
  • Lee, M.J. (College of medicine, Seoul National University) ;
  • Kim, J.J. (College of medicine, Seoul National University) ;
  • Sheen, Y.Y. (College of Pharmacy, Ewha Womans University)
  • Published : 2001.05.01
Download PDF
⟨ Previous Next ⟩

Abstract

The commercially available paclitaxel product, Taxol$\circledR$ is currently formulated in a vehicle containing approximately a 1:1 v/v mixture of polyoxyethylated castor oil (Cremophor EL) and ethanol. Cremophor EL, a commonly used surfactant for lipophilic compounds, has been associated with many issues, such as adverse effects particularly following rapid administration, stability with the possibility for drug precipitation upon dilution, and filtering requirements.(omitted)

Keywords