Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.05a
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- Pages.124-124
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- 2001
TETRAHYDROPAPAVEROLINE INDUCES DNA DAMAGE AND APOPTOTIC CELL DEATH THROUGH GENERATION OF REACTIVE OXYGEN SPECIES
- Shin, Mi-Hyun (College of Pharmacy, Seoul National University) ;
- Jang, Jung-Hee (College of Pharmacy, Seoul National University) ;
- Lee, Jeong-Sang (College of Pharmacy, Seoul National University) ;
- Surh, Young-Joon (College of Pharmacy, Seoul National University)
- Published : 2001.05.01
Abstract
Tetrahydropapaveroline(THP), a dopamine-derived 6,7-dihydroxy-l-(3',4'-dihydroxybenzyl)-1,2,3,4-tetrahydrosioquinoline, has been suspected as a possible dopaminergic neurotoxin to elicit Parkinsonism. Autoxidation or monoamine oxidase-mediated oxidation of THP and subsequent generation of reactive oxygen species (ROS) may contribute to the degeneration of dopaminergic neurons induced by this isoquinoline alkaloid.(omitted)
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