Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.05a
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- Pages.123-123
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- 2001
ORGANOPHOSPHATE-INDUCED BRAIN DAMAGE: NECROSIS, APOPTOSIS AND GFAP EXPRESSION
- Kim, Yun-Bae (Biomedical Section (GSDC-2-4), Agency for Defense Development) ;
- Hur, Gyeung-Baeng (Biomedical Section (GSDC-2-4), Agency for Defense Development) ;
- Phi, Taek-San (Biomedical Section (GSDC-2-4), Agency for Defense Development) ;
- Cheon, Ki-Cheol (Biomedical Section (GSDC-2-4), Agency for Defense Development) ;
- Kim, Wang-Soo (Biomedical Section (GSDC-2-4), Agency for Defense Development) ;
- Yeon, Gyu-Baek (Biomedical Section (GSDC-2-4), Agency for Defense Development)
- Published : 2001.05.01
Abstract
The distribution of necrotic and apoptotic neural cells, and expression of astrocytic glial fibrillary acidic protein (GFAP) in the brain of rats poisoned intraperitoneally with diisopropylfluorophosphate were investigated. Pyridostigmine bromide (0.1 mg/kg) and atropine methylnitrate (20 mg/kg), which are centrally inactive, were treated intramuscularly 30 min and 10 min, respectively, before diisopropylfluorophosphate (4 - 10 mg/kg) poisoning to reduce the mortality.(omitted)
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