한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
- /
- Pages.41-83
- /
- 2001
The MEK Inhibitor, PD98059 Blocks the Transactivation, but not the Stabilization or DNA Binding Ability, of Hypoxia-Inducible Factor-1$\alpha$
- Hur, Eun-Seon (Department of Life Science, University of Seoul) ;
- Chang, Keun-Young (Department of Life Science, University of Seoul) ;
- Lee, Eun-Jung (College of Pharmacy, Seoul National University) ;
- Lee, Seung-Ki (College of Pharmacy, Seoul National University) ;
- Park, Hyun-Sung (Department of Life Science, University of Seoul)
- 발행 : 2001.05.01
초록
Under low oxygen tension, cells increase the transcription of specific genes that are involved in angiogenesis, erythropoiesis and glycolysis. Hypoxia-induced gene expression primarily depends on the stabilization of the subunit of Hypoxia-Inducible Factor-1 (HIF-1), which acts as a heterodimeric transactivator.(omitted)
키워드