Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.05a
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- Pages.9-13
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- 2001
GENISTEIN-INDUCED G2/M ARREST IS ASSOCIATED WITH p53-INDEPENDENT INDUCTION OF Cdk INHIBITOR $p21^{WAF1/CIP1}$ IN HUMAN CANCER CELLS
- Park, Yung-Hyun (Department of Biochemistry, College of Oriental Medicine, Dong-Eui University)
- Published : 2001.05.01
Abstract
Genistein, a natural isoflavonoid phytoestrogen, is a strong inhibitor of protein tyrosine kinase and DNA topoisomerase II activities. Genistein has been shown to have anticancer proliferation, differentiation and chemopreventive effects. In the present study, we have addressed the mechanism of action by which genistein suppressed the proliferation of p53-null human prostate carcinoma cells.(omitted)