Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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MOLECULAR TARGETS IN SIGNALING PATHWAYS MEDIATING ANTI-TUMOR EFFECTS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs)

  • Hwang, Daniel (Pennington Biomedical Research Center, Louisiana State University)
  • Published : 2001.05.01
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Abstract

Many epidemiological studies have revealed that the use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) can reduce the risk of colon cancer. Since the well-documented pharmacological action of aspirin and other NSAIDs is the inhibition of cyclooxygenase [COX, the rate-limiting enzyme in prostaglandin (PG) biosynthesis], it has been inferred that the beneficial effect of NSAIDs may be mediated through the inhibition of PG biosynthesis.(omitted)

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