대한의용생체공학회:학술대회논문집 (Proceedings of the KOSOMBE Conference)

대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
권호 표지

광화학적 방법으로 친수성막이 고정화된 생체 재료의 표면특성 분석

The Surface Characteristics of Biomaterials Fixed with a Hydrophilic Membrane by Photochemical Reaction

  • 김현정 (서울대학교 의대 의공학연구소) ;
  • 전성민 (서울대학교 의대 의공학연구소) ;
  • 이규백 (서울대학교 의대 의공학연구소) ;
  • 민병구 (서울대학교 의대 의공학과)
  • Kim, H.J. (Institute of Biomedical Engineering, College of Medicine, Seoul National University) ;
  • Jeon, S.M. (Institute of Biomedical Engineering, College of Medicine, Seoul National University) ;
  • Lee, K.B. (Institute of Biomedical Engineering, College of Medicine, Seoul National University) ;
  • Min, B.G. (Department of Biomedical Engineering, College of Medicine, Seoul National University)
  • 발행 : 1997.05.23
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

We used the photoreactive poly(allylamie) (PPA) as the hydrophilic membrane to control the release of drug from polyurethane(PU). PPA was covalently bonded onto PU surface through the highly reactive nitrene intermediate upon UV light irradiation $(3.3mW/cm^2)$ at 254nm for 5min. Thus the release rate of rifampicin from PU surface was controlled. To know the characteristics of PU surface bonded with PPA, we measured the ATR-FTIR, ESCA, Static Contact Angle and SEM. From these, we suggest that PPA as a hydrophilic membrane is enable to control the release rate of a hydrophobic drug from polymer without the change of bulk property.

키워드