Proceedings of the KOSOMBE Conference (대한의용생체공학회:학술대회논문집)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Evaluation of Electrohydraulic Left Ventricular Assist Device through Animal Experiment

동물실험을 통한 전기유압식 좌심실 보조장치의 성능 평가

  • Choi, J.S. (Dept. of Biomedical Engineering, Graduate School, Seoul National University) ;
  • Chung, C.I. (Dept. of Biomedical Engineering, Graduate School, Seoul National University) ;
  • Choi, W.W. (Dept. of Biomedical Engineering, Graduate School, Seoul National University) ;
  • Park, S.K. (Dept. of Biomedical Engineering, College of Medicine, Seoul National University) ;
  • Jo, Y.H. (Dept. of Biomedical Engineering, College of Medicine, Seoul National University) ;
  • Om, K.S. (Dept. of Biomedical Engineering, Graduate School, Seoul National University) ;
  • Lee, J.J. (Dept. of Biomedical Engineering, Graduate School, Seoul National University) ;
  • Won, Y.S. (Dept. of Thoracic Surgery, College of Medicine, Ewha Women's University) ;
  • Kim, H.C. (Dept. of Biomedical Engineering, College of Medicine, Seoul National University) ;
  • Kim, W.G. (Dept. of Thoracic Surgery, College of Medicine, Seoul National University) ;
  • Min, B.G. (Dept. of Biomedical Engineering, College of Medicine, Seoul National University)
  • 최재순 (서울대학교 대학원 협동과정 의용생체공학) ;
  • 정찬일 (서울대학교 대학원 협동과정 의용생체공학) ;
  • 최원우 (서울대학교 대학원 협동과정 의용생체공학) ;
  • 박성근 (서울대학교 의과대학 의공학교실) ;
  • 조영호 (서울대학교 의과대학 의공학교실) ;
  • 엄경식 (서울대학교 대학원 협동과정 의용생체공학) ;
  • 이종진 (서울대학교 대학원 협동과정 의용생체공학) ;
  • 원용순 (이화여자대학교 의과대학 흥부외과교실) ;
  • 김희찬 (서울대학교 의과대학 의공학교실) ;
  • 김원곤 (서울대학교 의과대학 흉부외과학교실) ;
  • 민병구 (서울대학교 의과대학 의공학교실)
  • Published : 1996.05.17
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Abstract

We have been developed electrohydraulic left ventricular assist device and done various in vivo evaluation on the device. Through the in vivo experiment conducted from Jan. 23, 1996 to Feb. 8, we could have experience of long-term evaluation fur the first time. The sheep used in this experiment had survived for 16 days. We used new actuator with reduced size and linear motion guide replacing oil box and ball bearings. Also, we used improved blood chamber with reduced size, reduced weight facilitating fixing the chamber to animal's body, and polymer sac having improved folding pattern. Against suction problem, we used absolute pressure limiter only. Motor current for driving this new actuator was not much higher than older one. Effective stroke volume was about 48 cc. Thrombosis was found around top area and peripheral boundary of the sac and valves. There was no sign of damage from suction problem in the atrium observed at autopsy. Main cause of death was presumed to be progressive formation of thrombosis in the cannulae. In this paper, the results of this experiment are documented.

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