한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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- Pages.338-338
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- 1994
d-Limonene and Cineole Inhibition of Benzo(a) pyrene-Induced Mutagenicity and Lipid Peroxidation
- Kang, Eun-Mee (College of Pharmacy, Duksung Womens University) ;
- Park, Sung-Bae- (Seoul Metropolitan Government Institute of Health and Environment) ;
- Kim, Sang-Geon- (College of Pharmacy, Duksung Womens University) ;
- Jung, Ki-Hwa (College of Pharmacy, Duksung Womens University)
- 발행 : 1994.04.01
초록
The present study was designed to compare the effects of d-1 imonene and cineole on the benzo(a) pyrene (BP)-induced mutagenicity, BP metabol ism and lipid peroxidation. Modified Ames assay was employed to evaluate the inhibitory effect of d-1 imonene and cineole on the BP-induced mutagenici ty. The number of revertant-bearing wet Is was decreased by 44∼77% in the presence of both BP and d-1 imonene compared with that of BP alone wherease cineole decreased the nutter of revertant-bearing wet Is by 28∼45% at the concentrations between 2
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