APPLICATION OF SIMULATED ANNEALING FOR THE MATHEMATICAL MODELLING OF IMMUNE SYSTEMS

Cellular kinetics formulate the basis of tumor immune system dynamics which may be synthesized mathematically as cascades of bilinear systems which are connected by nonlinear dynamical terms. In this manner, a foundation for the control of syngeneic tumors is presented. We have analyzed the mechanisms of controlling the infiltration of lymphocytes into tumor tissues. Simulated anneal ins, a general-purpose method of multivariate optimization, is applied to combinatorial optimization, which is to find the minimum of a given function depending on many parameters. We compare the results of the different methods including the global optimization algorithm, known as simutated annealing.