고려인삼학회:학술대회논문집 (Proceedings of the Ginseng society Conference)

고려인삼학회 (The Korean Society of Ginseng)
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중크롬산 유발 급성신부전증에 미치는 홍삼 $S_I$-분획의 효과

The Protective Effect of Red Ginseng $S_I-fraction$ against Dichromate-Induced Acute Renal Failure

  • 나기정 (한국인삼연초연구소) ;
  • 강규상 (한국인삼연초연구소) ;
  • 김은 (한국인삼연초연구소)
  • Na Ki Jung (Korea Ginseng and Tobacco Research Institute) ;
  • Kang Kyu Sang (Korea Ginseng and Tobacco Research Institute) ;
  • Kim Eun (Korea Ginseng and Tobacco Research Institute)
  • 발행 : 1988.08.01
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초록

홍삼 $S_I$-분획의 투여로 중크롬산에 의한 신장세포독성이 감소되었다. 토끼에 중크롬산을 투여하면 급성신부전이 유발되어 10일이내에 대부분이 죽었다. 반면 홍삼 $S_I$-분획을 투여하면 치사율이 상당히 낮아졌으며, 생리적 증상이 현저히 개선되었다. 홍삼 $S_I$-분획의 투여로 중크롬산에 의하여 생기는 glomerulotubular imbalance가 호전되었으며, 당원생성, 해당속도, 젖산 생성속도가 정상화 되었다. 홍삼 $S_I$-분획의 효과는 비타민 C, EDTA, 휴로세마이드에 비하여 월등하였다.

The nephrotoxicity of dichromate was reduced upon the administration of red ginseng $S_I-fraction$. Rabbits treated with dichromate showed acute renal failure and the majority of animals died within ten days. Mortality and physioligical status were significantly improved by the administration of ginseng. The effect of red ginseng $S_I-fraction$ was studied by hematological analysis. urinalysis. and histophathological examination. It was found that red ginseng $S_I-fraction$ has a potent effect on glomerulotubular imbalance induced by dichromate. In addition, $S_I-fraction$ normalized the rate of glycogenolysis. glycolysis. and the rate of lactate production. which had been accelerated by intravenous dichromate injection. Red ginseng $S_I-fraction$ was superior to ascorbic acid. CaEDT A and furocemide in the protection and recorvery from dichromate-induced acute renal failure.

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