고려인삼학회:학술대회논문집 (Proceedings of the Ginseng society Conference)
- 고려인삼학회 1988년도 학술대회지
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- Pages.39-42
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- 1988
Mouse Liver의 Cytosolic Epoxide Hydrolase 활성도에 미치는 인삼 사포닌 분획의 영향
Protective Effect of Ginseng on Bromobenzene-Induced Hepatotoxicity in Mice
- Huh Keun (Department of Pharmacology, College of Pharmacy, Yeungnam University) ;
- Jang Byung-Su (Department of Pharmacology, College of Pharmacy, Yeungnam University) ;
- Park Jong-Min (Department of Pharmacology, College of Pharmacy, Yeungnam University)
- 발행 : 1988.08.01
초록
이 연구는 mouse liver의 epoxide hydrolase에 대한 인삼 사포닌 분획들의 효과를 검정하기 위해 고안되었다. Epoxide hydrolase는 반응성을 갖는 수많은 epoxide 중간물질들의 독성 및 발암성으로부터 세포를 보호하는데 중요한 역할을 하는 효소들의 한 group이다. Cytosolic epoxide hydrolase 활성도는 저농도의 사포닌 분획 첨가시에는 농도에 비례하여 활성이 증가되었으나, 고농동에서는 반대효과를 나태냈다. 수일간 인삼 사포닌 분획을 처리한 epoxide hydrolase의 활성도는 무처리에 비해 유의하게 증가되었음이 관찰되었다.
We have studied the mechanism by examing the effect of ginseng on the epoxide hydrolase which is catabolized the reactive intermetabolite of bromobenzene. and bromobenzene-induced hepatotoxicity. It was observed that ginseng saponin fraction protects against bromobenzene-induced hepatotoxicity in mice as evidenced 1. increased the epoxide hydrolase activity. 2. lower serum transaminase activity. 3. decreased the formation of lipid peroxide. These results suggested that the inducing effect of ginseng on the epoxide hydrolase is believed to be a possible detoxication mechanism for the bromobenzene toxicity in mice.
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