• Archives of Plastic Surgery
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• 제35권6호
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• pp.748-750
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• 2008

Purpose: Chemical burn accounts for a small proportion of burns in burn patient population. However, chemical injuries own importance to their deep tissue destruction which continues long after the initial exposure. $YUHANROX^{(R)}$ is a domestic bleach which has been widely used in Korea. Chemical burn by the domestic bleach is an unusual case. Methods: A 70 yrs old female soiled with stool, her husband wiped the mess with $YUHANROX^{(R)}$. Skin edema, erythematous lesion was developed the second day, and she was admitted to our hospital via emergency department. Results: Complete epithelization was done after 3 times STSG but, severe scar was formed. Conclusion: We report this case to warn about the dangers of domestic bleaches chemical substances and to emphasize that they should be used with caution. Public relation of the primary care of the chemical burn injury is needed.

• The Korean Journal of Pain
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• 제9권1호
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• pp.215-218
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• 1996

Frostbite involves freezing of tissues and usually affects the distal aspects of the extremities or exposed parts of the face. such as the ears, nose, chin, and cheeks. It produces tissue injury by ice crystal formation between the cells, cellular dehydration, and microvascular occulsion. There are four degrees of frostbite. First degree is accompanied by erythema and edema; second degree, by vesiculation, blistering, and eschar formation; third degree, by hemorrhagic blistering and bluish gray discoloration; and fourth degree, by injury to subcutaneous tissue, muscle, tendon, and bone leading to mottled, dry, black, and necrotic changes. We successfully treated 2 patients suffering from frostbite by performing sympathetic ganglion block with pure alcohol. We concluded sympathetic ganglion block is one of the most effective treatments for frostbite.

• 한국임상수의학회지
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• 제34권3호
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• pp.213-217
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• 2017

A 1-year and 8-month-old male, thoroughbred horse showed fever ($39.8^{\circ}C$), cardiac murmur, tachycardia up to 80 beats/min, anorexia, depression and lameness for about 2 months. The dead horse was referred to pathology laboratory at the College of Veterinary Medicine in Jeju National University. At necropsy, Severe protruding multiple rough cauliflower-like yellowish red nodules ranged $5{\sim}6{\times}2{\sim}3cm$ in size were attached on the mitral valve of the left heart. A yellowish red long stick-shaped thrombus $15{\times}3.5{\times}1.5cm$ in size was also present inside the right ventricle. Multifocal infarcts were scattered in the myocardium and renal cortex. Histopathologic examination revealed that morphologic diagnosis were vegetative endocarditis, thrombus in right ventricle, infarcts in myocardium and kidney, pulmonary congestion and edema, and splenic congestion. The isolated bacteria from vegetative lesions and thrombus were confirmed as Escherichia (E.) coli based on the bacterial culture and VITEK 2 system. Based on the gross and histopathologic features, and bacterial test, this case was diagnosed as vegetative endocarditis with thrombus formation associated by E. coli in a thoroughbred horse.

• 혜화의학회지
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• 제8권1호
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• pp.425-449
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• 1999

For the evaluation of the effect on SWS, experiments were made on hyperlipidemia induced by hypercholesterol diet, inhibitory reaction to human platelet aggregation, Pulmonary thrombosis induced by collagen and epinephrine, global cerebral ischemia induced by KCN, brain ischemia induced by MCA occlusion, cytotoxicity of PC12 cells induced by amyloid ${\beta}$ protein(25-35), and NO production in RAW cells stimulated by lipopolysaccharide. The results were obtained as follows : 1. In the experiment on hyperlipidemia, the level of serum total cholesterol, phospholipid, and LDL-cholesterol were significantly decreased while the level of triglyceride, VLDL-cholesterol, and HDL-cholesterol had no significant change. 2. In the experiment on inhibitory reaction to platelet aggregation, SWS inhibited platelet aggregation induced by ADP(36.05%), by collagen(20.4%), and by thrombin(0.6%). 3. In the experiment on pulmonary thrombosis induced by collagen and epinephrine, the protective effect was found(37%). 4. In the experiment on global cerebral ischemia, coma duration induced by KCN changed insignificantly. 5. In the experiment on MCA occlusion, the change of neurologic grades on hind limb was significant only after the operation. Besides brain ischemic area and edema ratio were significantly decreased. 6. In the experiment on cytotoxicity of PC 12 cells induced by amyloid ${\beta}$ protein, the significant protective effect was found as concentration increases. 7. In the experiment on NO production in RAW cells stimulated by lipopolysaccharide, NO was significantly decreased. According to the results, it is expected that SWS might be effective on hyperlipidemia and brain damage.

• Parasites, Hosts and Diseases
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• 제57권3호
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• pp.291-294
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• 2019

Primary amebic encephalitis (PAM) is a devastating central nervous system infection caused by Naegleria fowleri, a free-living amoeba, which can survive in soil and warm fresh water. Here, a 43-year-old healthy male was exposed to warm freshwater 5 days before the symptom onset. He rapidly developed severe cerebral edema before the diagnosis of PAM and was treated with intravenous conventional amphotericin B while died of terminal cerebral hernia finally. Comparing the patients with PAM who has similar clinical symptoms to those with other common types of meningoencephalitis, this infection is probably curable if treated early and aggressively. PAM should be considered in the differential diagnosis of purulent meningoencephalitis, especially in patients with recent freshwater-related activities during the hot season.

• Journal of Microbiology and Biotechnology
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• 제34권4호
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• pp.828-837
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• 2024

Vancomycin (VAN) and metronidazole (MTR) remain the current drugs of choice for the treatment of non-severe Clostridioides difficile infection (CDI); however, while their co-administration has appeared in clinical treatment, the efficacy varies greatly and the mechanism is unknown. In this study, a CDI mouse model was constructed to evaluate the therapeutic effects of VAN and MTR alone or in combination. For a perspective on the intestinal ecology, 16S rRNA amplicon sequencing and non-targeted metabolomics techniques were used to investigate changes in the fecal microbiota and metabolome of mice under the co-administration treatment. As a result, the survival rate of mice under co-administration was not dramatically different compared to that of single antibiotics, and the former caused intestinal tissue hyperplasia and edema. Co-administration also significantly enhanced the activity of amino acid metabolic pathways represented by phenylalanine, arginine, proline, and histidine, decreased the level of deoxycholic acid (DCA), and downregulated the abundance of beneficial microbes, such as Bifidobacterium and Akkermansia. VAN plays a dominant role in microbiota regulation in co-administration. In addition, co-administration reduced or increased the relative abundance of antibiotic-sensitive bacteria, including beneficial and harmful microbes, without a difference. Taken together, there are some risks associated with the co-administration of VAN and MTR, and this combination mode should be used with caution in CDI treatment.

• 대한수의학회지
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• 제47권3호
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• pp.315-319
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• 2007

Fibrinopurulent peritonitis and abdominal abscesses associated with Streptococcus (S.) equi subsp. zooepidemicus is reported in a 1-year-old female thoroughbred horse. The horse died after showing 5-day history of the cold, severe abdominal distention, abdominal breathing, hyperthermia, anorexia, and loss of intestinal sound. At necropsy, several liters of turbid yellowish green fluid were seen in the abdominal cavity. Yellowish creamy and fibrinous or bloody materials were presented on the serosa of various abdominal organs that were intensively adhered with each other. Spleen and mesenteric lymph node were remarkably enlarged. Affected lobes of the lung showed severe congestion, hemorrhage and doughy consistency. Histologically, the lung showed hemorrhagic pneumonia with diffuse congestion and edema. Severe diffuse fibrinopurulent peritonitis with Gram-positive bacterial cocci and adjacent fibrosis were showed in the serosa of various abdominal organs such as liver, spleen, stomach, and intestine. And multifocal abscess pouches were presented in the granulation tissue of abdominal viscera. S. equi subsp. zooepidemicus was isolated from the peritoneal swab, abdominal organs, and lung. Hematogenous dissemination of bacteria from hemorrhagic pneumonia is proposed as the route of infection in this case.

• 대한한의학원전학회지
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• 제21권1호
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• pp.183-203
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• 2008

"Uihakdokseogi(醫學讀書記)" is a casual work which mentions Ujaekyeong(尤在涇)'s thoughts on various problems found through extensive studying or in practice. The book does not focus on a single topic, thus the spectrum of the work is broad and is filled with problems which would interest most medical professionals. The major contents of the first volume of "Uihakdokseogi(醫學讀書記)" include differences of view on health preservation, the Five Circuit Phases[五運] and Six Atmospheric Influences[六氣], diseases, and the "Naegyeong(內經)", mentions on errors in transcription , and the gap between certain contents in "Yeongchu(靈樞)" and "Somun(素問)". U[尤在涇] asserts that Eum and Yang(陰陽) in a human should be in harmony as is the Gi(氣) of the sky and earth[天地] is, and that one should live according to the Gi(氣) of the four seasons to live a healthy life. He does not vary largely from the context of other writers on the matter of the Five Circuit Phases [五運] and Six Atmospheric Influences[六氣], and focuses on the concepts of predominant Gi[主氣], guest Gi[客氣], corresponding years[天符] , correlating years[歲會], and Taeeul corresponding years[太乙天符]. He mentions causes, symptoms, and treatments of various diseases such as cough due to asthenia of the viscera, stagnation of Yang(陽), stagnation of Eum(陰), abscess of the stomach, hard abscess of the intestines, upper emaciation, edema of the limbs, inability to raise the limbs, broken thigh, turbid fluid, inversion of Gi(氣) flow, sudden onset of fainting with cold extremities, diarrhea due to disorder of Gi(氣), and malaria. U[尤在涇] also points out faults of "Classic of Acupuncture and Moxibustion[甲乙經]" in the understanding of "Naegyeong(內經)".

• 여성건강간호학회지
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• 제7권4호
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• pp.610-621
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• 2001

In order to find out whether Hand Acupuncture Therapy and Moxibustion Heat Therapy is effective to relieve dysmenorrhea syndrome, we performed a Quasi-experiment on a group of fourty females. The experiment was carried out during the period from April 20 to August 20, 1999. The group was divided into two sub-groups called "a Hand Acupuncture Therapy sub-group" and "a Moxibustion Heat Therapy sub-group" consisting of 20 females respectively. Hand Acupuncture Therapy and Moxibustion Heat Therapy were performed four times a week. Especially, in case of Moxibustion Heat Therapy, subjects were treated twice a times. The data analyzed by an SAS program. The results are as follows : 1) Hand Acupuncture Therapy and Moxibustion Heat Therapy are very effective to relieve dysmenorrhea syndrome. This study shows that in case of Hand Acupuncture Therapy sub-group, supposing that mean score of Menorrhalgia before treatment was 7.85, it became low to 4.50 when. subjects suffered the first menstruation and it was 2.50 at the second menstruation, and 1.60 at the third menstruation. In the mean score of Moxibustion Heat Therapy sub-group, Menorrhalgia before treatment was 7.85, it was 5.90 at the first menstruation(p<.05), and 3.00 at the second, and 1.85 at the third menstruation. 2) Among Hand Acupuncture Therapy subgroup, 9 subjects could hardly be relieved from the pain of dysmenorrhea at the first menstruation. So, they were treated additionally with the method of tonification and sedation of abdominal diagnosis of three constitution and became completely relieved at second menstruation. Meanwhile, 7 subjects among Moxibustion Heat Therapy also faced the same situation. So they were treated with Moxibustion on dorsum of hand and got effectiveness at the third menstruation after taking therapy. 3) Odinary dysmenorrhea syndrome are constipation, dizziness, anorexia, abdominal pain, lumbago, breast engorgement, abdominal distention, dysconcentration, nervousness, diarrhea, nausea & vomitting, apathy, restlessness, fatigue, aggression, leg pain, edema. After taking therapy, all of subjects were relieved from these dysmenorrhea syndrome at third menstruation. 4) All subjects were classified into five types of physical constitution with abdominal diagnosis of three constitution as follows: 18 cases of left kidney right yang excess, 8 cases of left yin right yang excess, 7 cases of left right kidney excess, 5 cases of left right yang excess, 2 cases of left yang right kidney excess.

• Korean Journal of Acupuncture
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• 제24권2호
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• pp.217-230
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• 2007

Objectives : Ulcerative colitis or Crohn's disease has been recognized as Ha-ri (下痢) or Jang-Byok in Korean oriental medicine. A purpose of the present study is to investigate the anti-inflammatory effect of moxi-tar herbal acupuncture at LI4 (HapGok) on 2,4,6-trinitrobenzene sulphonic acid (TNBS) induced colitis in rats and further elucidate the possibility of herbal acupuncture on ulcerative colitis which is chronic inflammatory disease of the gastrointestinal tract. Methods : Sprague-Dawley rats, weighing $170{\sim}190$ g, were subjected to intrarectal injection of either saline (300 ${\mu}l$, 500 ${\mu}l$) for a control or 2,4,6-trinitrobenzene sulphonic acid (TNBS) (300 ${\mu}l$, 500 ${\mu}l$) for a colitis, Moxi-tar (20 mg/ml) were subcutaneously injected to the LI4 just after the secondary injection time of TNBS in rats. To study the effects of Moxi-tar acupuncture in LI4, body weight, RBC count, WBC count, total protein, Paw edema rate, rate of protein leakage into CMC-pouch fluid, IgG levels and IgM levels were observed. Results: Moxi-tar acupuncture in LI4 on TNBS-induced colitis inhibited the body weight lose rate but not effect RBC, WBC count. In addition, it inhibited the reduction of total protein concentration, paw edema, rate of protein leakage into CMC-pouch fluid, IgG levels and IgM levels. Conclusions : It is suggested that moxi-tar herbal acupuncture at LI4 helps to recover TNBS-induced colitis and plays an important role for an treatment of the irritable bowel syndrome (IBS).