• 한국치위생학회지
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• 제19권1호
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• pp.33-44
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• 2019

Objectives: To investigate how dental hygienists who have never used a digital oral scanner perceive the impression acquisition and evidence needed for prosthesis planning by using a digital oral scanner. Methods: From July 1, 2017 to December 31, 2017, subjects from Daegu, Gyeongsangbuk-do, Korea, were selected. The purpose of the study was described to dental hygienists who had never used a digital intraoral scanner. Questionnaires were distributed to the students selected. Of the 137 questionnaires distributed, 93 were used in the analysis after excluding 44 completed questionnaires that had errors or missing answers. Results: Of the respondents, 33.7% (36/93) were aged ${\geq}30$ years, 68.8% graduated from a 3-year vocational college course, 33.5% were aged ${\geq}33$ years, and 61.3%. At present, our center has the largest number of clinics (92.5%). The difficulty of impression taking using the digital oral scanner significantly differed (p<0.05) according to age and current occupation (p<0.05). Impression taking using a digital oral scanner significantly affected the present workflow of dental hygienists and their interest in sharing information about future use of digital oral scanner (p<0.01). Conclusions: If more routes are available to access digital intraoral scanners and more systems are developed for clinical use, the digital intraoral scanner could become digitized in the dental system; thereby, the existing impressions could be replaced with digitized impressions. With digital intraoral scanners, the expansion of the business of dental hygiene can be expected.

• The Journal of Advanced Prosthodontics
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• 제15권1호
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• pp.22-32
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• 2023

PURPOSE. Digital technology has enabled improvements in the fitting accuracy of denture bases via milling techniques. The aim of this study was to evaluate the trueness and precision of digital and analog techniques for manufacturing complete dentures (CDs). MATERIALS AND METHODS. Sixty identical CDs were manufactured using different production protocols. Digital and analog technologies were compared using the reference geometric approach, and the Δ-error values of eight areas of interest (AOI) were calculated. For each AOI, a precise number of measurement points was selected according to sensitivity analyses to compare the Δ-error of trueness and precision between the original model and manufactured prosthesis. Three types of statistical analysis were performed: to calculate the intergroup cumulative difference among the three protocols, the intergroup among the AOIs, and the intragroup difference among AOIs. RESULTS. There was a statistically significant difference between the dentures made using the oversize process and injection molding process (P < .001), but no significant difference between the other two manufacturing methods (P = .1227). There was also a statistically significant difference between the dentures made using the monolithic process and the other two processes for all AOIs (P = .0061), but there was no significant difference between the other two processes (P = 1). Within each group, significant differences among the AOIs were observed. CONCLUSION. The monolithic process yielded better results, in terms of accuracy (trueness and precision), than the other groups, although all three processes led to dentures with Δ-error values well within the clinical tolerance limit.

• Journal of Microbiology and Biotechnology
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• 제33권10호
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• pp.1351-1360
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• 2023

Endocrine-disrupting chemicals (EDCs) are compounds that disturb hormonal homeostasis by binding to receptors. EDCs are metabolized through hepatic enzymes, causing altered transcriptional activities of hormone receptors, and thus necessitating the exploration of the potential endocrine-disrupting activities of EDC-derived metabolites. Accordingly, we have developed an integrative workflow for evaluating the post-metabolic activity of potential hazardous compounds. The system facilitates the identification of metabolites that exert hormonal disruption through the integrative application of an MS/MS similarity network and predictive biotransformation based on known hepatic enzymatic reactions. As proof-of-concept, the transcriptional activities of 13 chemicals were evaluated by applying the in vitro metabolic module (S9 fraction). Identified among the tested chemicals were three thyroid hormone receptor (THR) agonistic compounds that showed increased transcriptional activities after phase I+II reactions (T3, 309.1 ± 17.3%; DITPA, 30.7 ± 1.8%; GC-1, 160.6 ± 8.6% to the corresponding parents). The metabolic profiles of these three compounds showed common biotransformation patterns, particularly in the phase II reactions (glucuronide conjugation, sulfation, GSH conjugation, and amino acid conjugation). Data-dependent exploration based on molecular network analysis of T3 profiles revealed that lipids and lipid-like molecules were the most enriched biotransformants. The subsequent subnetwork analysis proposed 14 additional features, including T4 in addition to 9 metabolized compounds that were annotated by prediction system based on possible hepatic enzymatic reaction. The other 10 THR agonistic negative compounds showed unique biotransformation patterns according to structural commonality, which corresponded to previous in vivo studies. Our evaluation system demonstrated highly predictive and accurate performance in determining the potential thyroid-disrupting activity of EDC-derived metabolites and for proposing novel biotransformants.

• Journal of the Korean Data and Information Science Society
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• 제27권5호
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• pp.1273-1284
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• 2016

본 연구에서는 기계 학습 분야의 특허를 수집하여 키워드 네트워크를 구축하고 클릭 분석을 실시하였다. 먼저 텍스트 마이닝 기법을 적용하여 핵심 키워드들을 선정한 다음, 이 키워드를 기반으로 키워드 네트워크를 구축하였다. 다음으로 네트워크 구조 분석, 중요 키워드 분석 및 클릭 분석을 시행하여 2005년도와 2015년도에 출원된 기계 학습 특허의 동향을 파악하였을 뿐만 아니라 양해년도의 분석 결과를 통해 특허 경향을 파악하였다. 분석 결과 기계 학습 특허의 키워드 네트워크는 밀도와 군집 계수가 낮은 것으로 드러났으며 기계 학습 기법 자체에 대한 특허보다는 다양한 응용 영역에서 기계학습을 적용한 특허들이 다수이기 때문으로 판단된다. 클릭 분석 결과 2005년도 클릭 분석에 의해 발견된 주제는 뉴스메이커 검증, 상품 소비 예측, 바이러스 공격 예방, 바이오마커, 그리고 워크플로우 관리였으며, 2015년도 기계 학습 특허 주제는 디지털 이미지 편집, 직불카드, 수신자 인라이닝 시스템, 유방 촬영 시스템, 재고 관리 시스템, 이미지 편집 시스템, 비행기 티켓 가격 예측, 그리고 문제 예측 시스템으로 나타났다. 2005년도에 비하여 2015년도의 근접 중앙성은 낮아지고 매개 중심성은 높아진 것으로 보아 최근의 특허 경향은 보다 다양한 분야에서 출원되고 있으며 이들 간의 연결이 활발해지고 있음을 알 수 있다. 클릭 분석은 클릭을 형성하는 키워드 집합을 해석하여 주제를 파악하는데 활용될 수 있을 뿐만 아니라 추출된 공유 멤버쉽 키워드 집합은 특허 검색 시스템과 같이 키워드 검색 기반의 시스템에서 검색 키워드로 활용될 수 있을 것으로 기대된다.

• 인터넷정보학회논문지
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• 제24권4호
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• pp.127-135
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• 2023

본 논문에서는 금융 뉴스 데이터로 추가적인 사전 학습이 진행된 BERT 기반 모델인 FinBERT 모델을 사용하여 금융 영역에서 감성 분석 시 학습시킬 데이터와 그에 맞는 하이퍼파라미터를 찾는 방법을 소개한다. 우리의 목표는 다양한 데이터 세트를 활용하고 하이퍼파라미터를 미세 조정하여 정확한 감성 분석을 위해 FinBERT 모델을 가장 잘 활용하는 방법에 대한 포괄적인 가이드를 제공하는 것이다. 이 연구에서는 제안된 FinBERT 모델 미세 조정 접근법의 아키텍처와 워크플로우를 개괄적으로 설명하고, 감성 분석 태스크를 위한 다양한 데이터 세트와 하이퍼파라미터의 성능을 강조한다. 또한, 감성 라벨링 작업에 GPT-3를 사용함으로써 GPT-3가 적절한 라벨러 역할을 하는지에 대한 신뢰성을 검증한다. 결과적으로 미세 조정된 FinBERT 모델이 다양한 데이터 세트에서 우수한 성능을 발휘 한다는 것을 보여주었고, 각 데이터 세트에 대해 전반적으로 우수한 성능을 보이는 학습률 5e-5와 배치 크기 64의 최적의 조합을 찾았다. 또 일반 도메인의 뉴스보다 일반 도메인의 트위터 데이터 세트에서 성능이 크게 향상됨을 기반으로 금융 뉴스 데이터만으로만 추가적으로 학습시키는 FinBERT 모델에 대한 의구심을 제시한다. 이를 통해 FinBERT 모델에 대한 최적의 접근 방식을 결정하는 복잡한 프로세스를 간소화하고 금융 분야 감성 분석 모델을 위한 추가적인 학습 데이터 세트와 미세 조정 시 하이퍼파라미터 선정에 대한 가이드라인을 제시한다.

• Asian-Australasian Journal of Animal Sciences
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• 제31권6호
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• pp.791-797
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• 2018

Objective: Trimethylation of histone 3 (H3) at 4th lysine N-termini (H3K4me3) in gene promoter region was the universal marker of active genes specific to cell lineage. On the contrary, coexistence of trimethylation at 27th lysine (H3K27me3) in the same loci-the bivalent H3K4m3/H3K27me3 was known to suspend the gene transcription in germ cells, and could also be inherited to the developed stem cell. In galline species, throughout example of H3K4m3 and H3K27me3 ChIP-seq analysis was still not provided. We therefore designed and demonstrated such procedures using ChIP-seq and mRNA-seq data of chicken follicular mesenchymal cells and male germ cells. Methods: Analytical workflow was designed and provided in this study. ChIP-seq and RNA-seq datasets of follicular mesenchymal cells and male germ cells were acquired and properly preprocessed. Peak calling by Model-based analysis of ChIP-seq 2 was performed to identify H3K4m3 or H3K27me3 enriched regions ($Fold-change{\geq}2$, $FDR{\leq}0.01$) in gene promoter regions. Integrative genomics viewer was utilized for cellular retinoic acid binding protein 1 (CRABP1), growth differentiation factor 10 (GDF10), and gremlin 1 (GREM1) gene explorations. Results: The acquired results indicated that follicular mesenchymal cells and germ cells shared several unique gene promoter regions enriched with H3K4me3 (5,704 peaks) and also unique regions of bivalent H3K4m3/H3K27me3 shared between all cell types and germ cells (1,909 peaks). Subsequent observation of follicular mesenchyme-specific genes-CRABP1, GDF10, and GREM1 correctly revealed vigorous transcriptions of these genes in follicular mesenchymal cells. As expected, bivalent H3K4m3/H3K27me3 pattern was manifested in gene promoter regions of germ cells, and thus suspended their transcriptions. Conclusion: According the results, an example of chicken H3K4m3/H3K27me3 ChIP-seq data analysis was successfully demonstrated in this study. Hopefully, the provided methodology should hereby be useful for galline ChIP-seq data analysis in the future.

• Genomics & Informatics
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• 제18권1호
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• pp.8.1-8.10
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• 2020

The explosive growth of next-generation sequencing data has resulted in ultra-large-scale datasets and ensuing computational problems. In Korea, the amount of genomic data has been increasing rapidly in the recent years. Leveraging these big data requires researchers to use large-scale computational resources and analysis pipelines. A promising solution for addressing this computational challenge is cloud computing, where CPUs, memory, storage, and programs are accessible in the form of virtual machines. Here, we present a cloud computing-based system, Bio-Express, that provides user-friendly, cost-effective analysis of massive genomic datasets. Bio-Express is loaded with predefined multi-omics data analysis pipelines, which are divided into genome, transcriptome, epigenome, and metagenome pipelines. Users can employ predefined pipelines or create a new pipeline for analyzing their own omics data. We also developed several web-based services for facilitating downstream analysis of genome data. Bio-Express web service is freely available at https://www. bioexpress.re.kr/.

• 한국ITS학회 논문지
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• 제7권3호
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• pp.82-94
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• 2008

Airport GIS는 공항의 안전과 효율성 향상을 기할 수 있는 종합정보시스템이다. 이에 국내 외 현황 및 관련 규정.표준화 정보를 검토하고, Test-bed인 김포공항에 대한 현황 및 요구분석을 통해 서비스 모델 도출 및 기초설계를 하여 Airport GIS에 대한 도입방안을 제시하였다. 우선적으로 도입될 6개 서비스 모델은 1) Airside 지역 이동체 안전관리, 2) 항공기-차량간 주요 교차지점 지능형 신호제어, 3) 이동지역 이물질, 포장면 파손 대응 능동형 안전관리, 4) 제방빙(Deicing) 등 특수지원 차량 원격관리, 5) 비상 상황시 소방 및 구급차량 등 외부 협정기관 대응 및 지원, 6) 공항 전력시설 등 필수지원시설 상황인식 능력 강화 및 대응으로 향후 이에 대한 상세설계 및 통합시스템 구축연구를 진행할 예정이다.

• 정보관리학회지
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• 제23권3호
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• pp.241-264
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• 2006

이 연구에서는 도서관에서 구독하는 전자자원의 효율적 관리를 위한 필수 전자자원 관리용 메타데이터를 제안하였다. 제안의 근거를 확보하기 위한 기초자료로 DLF ERMI 권고안을 비롯하여 해당 권고안을 제안한 연구컨소시엄에 참여한 UCLA 대학도서관, 노스캐롤라이나주립 대학도서관, Boston대학도서관의 전자자원 관리시스템의 메타데이터의 요소를 활용하였다. 이상의 기초자료를 비교, 분석하여 도출된 결과를 국내 전자자원관리담당자에 검증을 받았다. 그 결과 본 연구에서는 다음과 같이 전자자원 관리용 메타데이터 요소를 제안하였다. 트라이얼 법주는 트라이얼 URL을 포함한 총 12개 요소, 컨소시엄 법주는 컨소시엄 명을 포함한 총 15개 요소, 수서정보 범주는 부서 ID를 포함한 총 24개 요소, 라이선스 범주는 라이선서를 포함한 총 33개 요소, 전자자원 정보는 P-ISSN을 포함한 총 21개 요소, 접근/관리정보는 관리자ID를 포함한 총 20개 요소, 이용통계 범주는 이용통계 유형을 포함한 충 13개 요소, 워크플로우 범주는 워크플로우ID를 포함한 총 14개 요소, 연락정보 범주는 연락ID를 포함한 총 18개 요소이다.

• Journal of Preventive Medicine and Public Health
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• 제48권6호
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• pp.330-341
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• 2015

Objectives: Emergency medical personnel (EMPs) are pre-hospital emergency responders who are at risk of exposure to infections and may also serve as a source for the transmission of infections. However, few studies of infection control have specifically addressed EMPs in the Republic of Korea (hereafter Korea). The goal of this study was to assess the current status of infection prevention and control programs (IPCPs) for EMPs in Korea. Methods: A cross-sectional survey was conducted to quantitatively assess the resources and activities of IPCPs. A total of 907 EMPs in five metropolitan cities completed a structured questionnaire from September 2014 to January 2015. The data were analyzed using descriptive statistics, multi-response analysis, and the chi-square test. Results: The mean age of the participants was $34.8{\pm}15.1years$. IPCPs were found to have weaknesses with regard to the following resources: the assignment of infection control personnel (ICP) (79.5%), hand hygiene resources such as waterless antiseptics (79.3%), the use of paper towels (38.9%), personal protective equipment such as face shields (46.9%), and safety containers for sharps and a separated space for the disposal of infectious waste (10.1%). Likewise, the following activities were found to be inadequately incorporated into the workflow of EMPs: education about infection control (77.5%), post-exposure management (35.9%), and the decontamination of items and spaces after use (88.4%). ICP were found to have a significant effect on the resources and activities of IPCPs (p<0.001). The resources and activities of IPCPs were found to be significantly different among the five cities (p<0.001). Conclusions: IPCPs for EMPs showed some limitations in their resources and activities. IPCPs should be actively supported, and specific IPCP activities for EMPs should be developed.