• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3705-3709
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• 2013

Background: To investigate epidermal growth factor receptor (EGFR) gene mutations in patients with non-small cell lung cancer (NSCLC) and to analyze any relationship with clinicopathological features and prognosis. Materials and Methods: EGFR gene exons 18-21 in 48 specimens of paraffin-embedded tumor tissue from NSCLC patients were amplified by PCR, followed by direct sequencing and analysis of links to clinicopathological features and prognosis. Results: EGFR mutations were detected in 18 of 48 (42.6%) patients with NSCLC. There were 9 cases of mutations in exon 20, 7 in exon 19 and 2 in exon 21. Mutations were more frequently observed in women (5/7 pts, 71.4%) than in men (13/41 pts, 31.7%) (p=0.086) and in non-smokers (5/5 pts, 100%) than smokers (13/43 pts, 30.2%). There was negative correlation of EGFR mutations with smoking status (p=0.005). EGFR mutations were more frequently observed with adenocarcinoma histology (13/32 pts, 40.6%) than in other types (5/16 pts, 31.3%) (p=0.527). The patients with EGFR mutations had better survival than those with wild-type EGFR (p=0.08). There was no association of EGFR mutations with metastatic spread. Conclusions: EGFR mutations in NSCLC were here demonstrated more frequently in females, non-smokers and adenocarcinoma histology in the western region of Turkey. Patients with EGFR mutations have a better prognosis.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.17
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• pp.7407-7411
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• 2014

The incidence of urban female breast cancer has been continuously increasing over the past decade with unknown etiology. One hypothesis for this increase is carcinogen exposure from tobacco. Therefore, the objective of this study was to investigate the risk of urban female breast cancer from tobacco smoke exposure. The matched case control study was conducted among Thai females, aged 17-76 years and living in Bangkok or its surrounding areas. A total of 444 pairs of cases and controls were recruited from the Thai National Cancer Institute. Cases were newly diagnosed and histologically confirmed as breast cancer while controls were selected from healthy women who visited a patient, matched by age ${\pm}5$ years. After obtaining informed consent, tobacco smoke exposure data and information on other potential risk factors were collected by interview. The analysis was performed by conditional logistic regression, and presented with odds ratio (ORs) and 95% confidence intervals(CI). From all subjects, 3.8% of cases and 3.4% of controls were active smokers while 11.0% of cases and 6.1% of controls were passive smokers. The highest to lowest sources of passive tobacco smoke were from spouses (40.8%), the workplace (36.8%) and public areas (26.3%), respectively. After adjusting for other potential risk factors or confounders, females with frequent low-dose passive smoke exposure (${\leq}7$ hours per week) from a spouse or workplace had adjusted odds ratio 3.77 (95%CI=1.11-12.82) and 4.02 (95%CI=1.04-15.50) higher risk of breast cancer compared with non-smokers, respectively. However, this study did not find any association of breast cancer risk in high dose passive tobacco smoke exposure, or a dose response relationship in cumulative passive tobacco smoke exposure per week, or in the active smoker group. In conclusion, passive smoke exposure may be one important risk factor of urban female breast cancer, particularly, from a spouse or workplace. This risk factor highlights the importance of avoiding tobacco smoke exposure as a key measure for breast cancer prevention and control.

• The Journal of the Convergence on Culture Technology
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• v.4 no.4
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• pp.187-199
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• 2018

In this study, only 2,877 men, 2,614 men (44.6%), and 143 women (2.3%) were selected as the subjects who were over 18 years old in response to the health consciousness of the Korean medical panel data in 2012. Emergency of smokers through medical use and medical expenditure data by smoking. The social costs were estimated through medical expenses according to the number of hospitalization and outpatient medical use. The social cost was calculated by summing the social expenditure on health care costs, insurer (corporation) costs, copayment, non - salary, and productivity costs by adopting the social perspective established by the health economist Rice (1968). The rate of annual emergency medical use by smoking status is 7.5% for smokers per 100 people, 9.8 times for use, and 809,003 won for social expenses. The annual rate of hospitalization per 100,000 population by smoking status was 9.6% for smokers per 100 population, 9 times for use, The social cost is 706,870 won. Annual smoking rate by smoking status was 68.6% for smoking, 9 cases for annual medical use,

• Journal of dental hygiene science
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• v.22 no.2
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• pp.90-98
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• 2022

Background: Integrated management of general, mental, and oral health is necessary to improve an individual's quality of life. This study aimed to identify the effects of mental and oral health behaviors on metabolic syndrome. Methods: A total of 4,227 Korean adults aged 20 years or older were selected as study subjects using raw data from the first year (2019) of the 8th period of the Korea National Health and Nutrition Examination Survey (KNHANES). A complex sample chi-square test and a complex sample logistic regression analysis were performed using the PASW Statistics ver. 18.0 program. Results: The effect on metabolic syndrome was significantly higher in male than in 1.833 times in male, 2.914 times in 30~49 years old, and 3.855 times in 50~64 years old, and 3.929 times in people over 65 years old compared to 20~29 years old, and compared to those with a college degree or higher, those with a middle school degree or lower are 2.116 times, those with lower income levels are 1.507 times higher, those with middle-lower are 1.359 times higher, those with middle-high are 1.401 times. Compared to non-smokers, smokers were 1.570 times higher than non-smokers and compared to those without speech problem and chewing difficulty, they were 1.717 times and 1.397 times higher, respectively and 1.973 times higher in those with 0~1 brushing times per day. Mental health did not affect prevalence of metabolic syndrome. Conclusion: It is necessary to improve maintain a healthy lifestyle to lower the risk of metabolic syndrome. It is necessary to establish effective dental hygiene customized education and an efficient health management system at the national level that can induce improvement of oral health behavior for the prevention and management of metabolic syndrome.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.19 no.1
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• pp.16-22
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• 2012

Purpose: The purpose of this study was to identify Forced Vital Capacity (FVC), Forced Expiratory Volume in 1 Second ($FEV_1$), $FEV_1$/FVC according to obesity in young adult women. Method: Height, weight, body mass index (BMI), and percent body fat (PBF) were obtained by using bioelectrical impedance analysis. Neck circumference (NC), waist circumference (WC) and spirometric values (FVC, $FEV_1$, $FEV_1$/FVC) were obtained for 135 women college students who were healthy and non smokers. Results: Mean BMI and PBF were $21.8kg/m^2$ and 30.5%. Obesity prevalence according to BMI and PBF were respectively 13.3%, and 50.9%. Lean body mass (LBM) was positively correlated with FVC, $FEV_1$, and PBF was negatively correlated with FVC, $FEV_1$ and $FEV_1$/FVC. FVC and $FEV_1$ of the underweight or obese group were lower than those of normal weight group. Conclusion: PBF, but not BMI, is negatively associated with pulmonary function in women college students.

• Research in Community and Public Health Nursing
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• v.22 no.1
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• pp.45-55
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• 2011

Purpose: This study aimed to investigate the rate of and factors associated with influenza vaccination in Korean elderly people. Methods: For this retrospective cross-sectional study, we used data from the Korean National Health and Nutrition Examination Survey (KNHANES) 2008. A total of 1,516 men and women aged 65 or above were included. The data were analyzed using descriptive statistics and logistic regression. Results: The overall rate of influenza vaccination in 2008 was 73.6%. The vaccination rate was lower in women (73.2%) than in men (74.2%; p<.001). It was lower in the elderly aged 80 and above, those living in metropolitan areas, smokers, those who did not receive regular health screening, those who had no history of hospitalization within one year, and those who had liver diseases than in the other groups. The rate of vaccination was higher in those with cancer. Logistic regression analysis revealed that for both men and women, the significant correlates associated with vaccination were demographic factors, chronic disease and health behavior. Conclusion: The influenza vaccination coverage needs to be improved. Efforts should be made to reach the elderly population with relatively low influenza vaccination rates and to increase awareness about the importance of vaccination at a personal and community level.

• Journal of Preventive Medicine and Public Health
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• v.44 no.4
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• pp.157-166
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• 2011

Objectives: This study was conducted to show the intraocular pressure (IOP) distribution and the factors affecting IOP in subjects with type 2 diabetes mellitus (DM) in India. Methods: We measured the anthropometric and biochemical parameters for confirmed type 2 DM patients. A comprehensive ocular examination was performed for 1377 subjects aged > 40 years and residing in Chennai. Results: A significant difference in IOP (mean ${\pm}$ standard deviation) was found between men and women ($14.6{\pm}2.9$ and $15.0{\pm}2.8$ mmHg, p = 0.005). A significantly elevated IOP was observed among smokers, subjects with systemic hypertension and women with clinically significant macular edema (CSME). After a univariate analysis, factors associated significantly with higher IOP were elevated systolic blood pressure, elevated resting pulse rate and thicker central corneal thickness (CCT). In women, elevated glycosylated hemoglobin was associated with a higher IOP. After adjusting for all variables, the elevated resting pulse rate and CCT were found to be associated with a higher IOP. Conclusions: Systemic hypertension, smoking, pulse rate and CCT were associated with elevated intraocular pressure in type 2 DM. Women with type 2 DM, especially those with CSME, were more prone to have an elevated IOP.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.5087-5090
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• 2012

Oral cancer is a common site of head and neck cancer, and is relatively frequent in Northeast Thailand. The objective of this hospital-based, case-control study was to determine associations with risk factors. A total of 104 oral cancer cases diagnosed between July 2010 and April 2011 in 3 hospitals were matched with control subjects by age, sex and hospital. Data were collected by personal interview. There were significant associations between oral cancer and tobacco smoking (OR=4.47; 95%CI=2.00 to 9.99), alcohol use among women (OR=4.16; 95%CI=1.70 to 10.69), and betel chewing (OR=9.01; 95%CI=3.83 to 21.22), and all three showed dose-response effects. Smoking is rare among Thai women (none of the control women were smokers), but betel chewing, especially among older women, is relatively common. We did not find any association between practicing oral sex and oral cancer.

• The Korean Journal of Rehabilitation Nursing
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• v.11 no.1
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• pp.41-48
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• 2008

Purpose: The study were to identify difference in self-efficacy according to perceived health status in male smokers. Methods: The subjects were 138 male smoker in Seoul and Incheon. The data was collected using structured questionnaires from ninth of July to 16th of August in 2007. The data was analyzed by descriptive statistics and ANOVA with SPSS 14.0. Result: Participants showed that a high level of total self-efficacy score $3.40{\pm}.43$, general self-efficacy score $3.39{\pm}.46$, social self-efficacy score $3.44{\pm}.55$. There were significant difference total self-efficacy and general self-efficacy in accordance with perceived health status. But there were no significant difference social self-efficacy in accordance with perceived health status. With the result of this study, the subjects smoked $14.48{\pm}11.04$ years and 90.4% of the subjects were highly perceived that the health status of oneself above of moderate state and self-efficacy score. Conclusion: Therefore raising a perception about smoking dangerous, the prohibition of smoking program development which emphasizes the noxiousness of smoking for must precede, recognizes the necessity of prohibition of smoking and prohibition of smoking decision in one smoker comes to seem with the fact that own effect increase program for a prohibition of smoking maintenance.

• Korean Journal of Health Education and Promotion
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• v.20 no.4
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• pp.41-50
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• 2003

Objectives： The purpose of this paper is to analyze longevity factors of 507 centenarians in the Republic of Korea. Methods： This paper is designed to survey physical, mental, socio-demographic and dietary factors of 507 centenarians. The data was collected by means of telephone interview from 1999 to 2001. The survey directly contacted centenarians who were able to communicate, or contacted the centenarians caregivers. The association between longevity factors of centenarians was verified by odds ratio of logistic regression. Results： Female centenarians appeared to be non-smokers more often than males (OR＝4.06, CI＝2.06, 7.98). The longevity of persons with a small waist circumference was attributed to health promotion through eating lightly as well as keeping active including walking(OR＝2.37, CI＝1.36, 4.14). A higher probability for longevity is found among optimists who live a happy life and 1aught every day (OR＝26.15, CI＝11.61, 58.89). Among centenarians, vegetarians were shown to be light eaters. More ratios of vegetarians among centenarians included those who reside in a rural district, eat bean paste soup everyday, and consume small quantities of meat (OR＝5.12, CI＝3.24, 8.08). Conclusion： Women, manual workers, under poor to middle economic status, rural residents, optimists, light eaters, vegetarians and non-smokers seemed to have a higher probability of becoming centenarians in The Republic of Korea.