• Nutrition Research and Practice
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• 제7권6호
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• pp.466-474
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• 2013

Despite the reports on safety concerns regarding the relationship between aluminum salts and neurological and bone disease, many countries continue to use aluminum as phosphate binders among patients with renal failure. In search for a diet supplement that could reduce aluminum toxicity related to renal failure, we carried out this prospective animal study in which the fenugreek seeds were assessed for their effects on rats nephrotoxicity induced by aluminum chloride ($AlCl_3$). Oral $AlCl_3$ administration during 5 months (500 mg/kg bw i.g for one month then 1600 ppm via drinking water) led to plasma biochemical changes, an inhibition of alkaline phosphatase (ALP), a decrease of total antioxidant status (TAS), and an induction of lipid peroxidation (LPO) in the blood and brain, in addition to kidney atrophy and morphological alterations at the level of Bowman's capsule, the glomerulus and different sorts of tubules, reminiscent of some known kidney disease. The treatment with the whole fenugreek seed powder (FSP) (5% in the diet) during the last 2 months showed its effectiveness in restoring normal plasma values of urea, creatinine, ALP and glucose, as well as re-increasing the TAS, inhibiting LPO and alleviating histopathological changes in the injured kidneys. This study highlights the induced nephrotoxicicity, as well as the related toxicity in the brain and bone, by chronic oral ingestion of the aluminum salts. However, the maintenance of a diet supplemented with fenugreek seeds could offer protection for the kidney, bone and brain, at the same time.

• Molecules and Cells
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• 제27권2호
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• pp.263-268
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• 2009

Gamma knife surgery (GKS) is used for the treatment of various human brain disorders. However, the biological effects of gamma ray irradiation on both the target area, and the surrounding tissues are not well studied. The effects of gamma ray exposure to both targeted and untargeted regions were therefore evaluated by monitoring gene expression changes in the unilateral irradiated (60 Gy) and contralateral un-irradiated striata in the rat. Striata of irradiated and control brains were dissected 16 hours post-irradiation for analysis using a whole genome 44K DNA oligo microarray approach. The results revealed 230 induced and 144 repressed genes in the irradiated striatum and 432 induced and 239 repressed genes in the unirradiated striatum. Out of these altered genes 39 of the induced and 16 of the reduced genes were common to both irradiated and un-irradiated tissue. Results of semiquantitative, confirmatory RT-PCR and western blot analyses suggested that ${\gamma}$-irradiation caused cellular damage, including oxidative stress, in the striata of both hemispheres of the brains of treated animals.

• Clinical and Experimental Pediatrics
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• 제46권10호
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• pp.1040-1043
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• 2003

저자들은 9세 남아에서 고혈압과 뇌혈관염이 동반된 상태에서 뇌증을 보인 HSP 신염 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Journal of Korean Neurosurgical Society
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• 제29권7호
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• pp.963-967
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• 2000

The aneurysm arising from the posterior cerebral artery is relatively uncommon, and has been reported in 0.7- 2.2% of whole cerebral aneurysm. Moreover, only a few cases of the giant aneurysm over 2.5cm in diameter arising from the distal portion of the posterior cerebral artery have been reported. Neurologic complications may occur after surgical treatment of this aneurysm due to difficult surgical approach and neurovascular complexity around the brain stem. Authors experienced a case of the thrombosed giant aneurysm with approximately 2.7cm in diameter arising from the P2 segment of the left posterior cerebral artery. Complete removal of the thrombus in the aneurysmal sac and direct neck clipping was performed via left subtemporal approach.

• 생명과학회지
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• 제21권8호
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• pp.1163-1167
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• 2011

과다한 음주는 알츠하이머 및 파킨슨 질병과 같은 각종 만성 퇴행성 뇌질환의 대표적인 원인 중 하나로 알려져 있다. 체내에 유입된 에탄올은 알코올 탈수소효소(alcohol dehydrogenase, ADH)에 의해 아세트알데히드로 대사된 후 다시 알데히드탈수소효소 2(aldehyde dehydrogenase 2, ALDH2)에 의해 아세트산으로 대사되어 배출된다. 에탄올의 대사과정 중에는 다량의 free radical이 생성되어 체내에서 산화적 스트레스를 유발하는 것으로 알려져 있고, 아세트알데히드는 활성산소를 생산하는 독성물질로 잘 알려져 있다. 본 연구에서는 8주간 에탄올에 노출된 Aldh2 knockout 마우스를 사용하여 ALDH2 효소 활성이 뇌 조직과 소변의 지질과산화에 미치는 영향에 대하여 살펴보았으며, 지질과산화 정도를 측정하기 위해 HPLC를 통한 TBARS 정도를 측정하였다. 연구결과, 마우스에서 만성 에탄올 섭취는 뇌 조직 TBARS 생성에 영향을 주지 않는 것으로 나타났으나, 소변 TBARS는 Aldh2 (-/-) 마우스에서 에탄올을 투여함에 따라 유의한 증가를 보였다(p<0.05). 본 연구 결과로부터 8주간 에탄올을 경구 투여한 마우스에서 ALDH2의 활성은 체내의 전반적인 활성산소 생성에는 중요하게 관여하는 것으로 보이지만 뇌조직에서의 활성산소 생성에는 영향을 주지 않는 것으로 보이며, 이는 에탄올 노출과 이에 따른 활성산소가 다양한 만성 뇌질환을 유발한다는 기존의 가설에서 ALDH2의 활성이 중요하게 관여하지 않을 가능성을 시사한다.

• 동의생리병리학회지
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• 제18권6호
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• pp.1585-1597
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• 2004

Facial palsy is a common disease in clinic, which can be classified into central and peripheral according to the causes. The central facial palsy is caused by cerebral vascular accident, brain tumor, etc. The peripheral facial palsy comes from cold stimulus on face, regional infection of virus, suppurative tympanitis, inflammation on mastoid process, pathological teeth, trauma like cranial fracture, and so forth, They have distinctive features in diagnosis. While the central facial palsy is followed by hemiplegia and articulation disorder, the peripheral one by the disappearance of wrinkles on the forehead and rising of eyeball on paralyzed side when closing the eyes. Most of the cases in this thesis are peripheral palsy. The social classes and ages of the patients are so various that the treatments must be applied from various standpoints. The statistical data shows that the functional weakness of the whole body is the fundamental condition of the facial palsy. Therefore it is very important to find and the exact pathology and treatment appropriate for Hyungsang of the patients.

• Journal of Korean Neurosurgical Society
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• 제51권1호
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• pp.47-50
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• 2012

We report here one case of rapid and aggressive course of cerebral metastatic angiosarcoma from the heart. A 36-year-old man presented with 10-days history of headache. Magnetic resonance imaging demonstrated subacute hemorrhage with a small region of enhancement in right parietal region and the pathological diagnosis was angiosarcoma. Transthoracic echocardiography demonstrated $3.2{\times}3$ cm sized mass on right atrial wall. Newly developed lesion was reoperated, three and four weeks later respectively, and whole brain radiotherapy of total 30 Gy was done. With the interval of two months, gamma knife surgery was done for new lesions two times, which were well controlled. Newly developed lesions rapidly happened even in the adjuvant treatment. He died 9 months after the diagnosis because of the aggravation of primary cancer. The cerebral metastatic angiosarcoma from the heart showed the rapid aggressive behavior and the closed follow-up could be needed for the adjuvant treatment.

• 대한방사선치료학회지
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• 제26권2호
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• pp.265-272
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• 2014

목 적 : 전뇌 방사선 치료 시 산란선으로 인하여 영향을 받는 갑상선의 피폭선량을 감소시키기 위해 차폐체를 사용하여 갑상선의 차폐 효과를 평가하고자 한다. 대상 및 방법 : 갑상선의 피폭선량을 측정하기 위해 선형가속기(Clinac iX. VARIAN, USA)를 이용하여 6 MV X선, 300 cGy를 인체모형팬텀에 대향 2문 조사하였다. 갑상선의 입사표면선량을 측정하기 위해 인체모형팬텀의 10번째 슬라이스 표면에 유리선량계 다섯 개를 1.5 cm 간격으로 위치시킨 후 차폐체 미사용, bismuth 차폐체 사용, 0.5 mmPb 차폐체 사용, 자체 제작한 1.0 mmPb 차폐체를 사용하여 각각 5회씩 측정하여 평균값을 산출하였다. 또한, 같은 위치에서 갑상선 심부선량을 측정하기 위해서 인체모형팬텀의 10번째 슬라이스 2.5 cm 깊이에서 유리선량계 다섯 개를 1.5 cm 간격으로 위치시킨 후 차폐체 미사용, bismuth 차폐체 사용, 0.5 mmPb 차폐체 사용, 자체 제작한 1.0 mmPb 차폐체를 사용하여 각각 5회씩 측정하여 평균값을 산출하였다. 결 과 : 갑상선의 입사표면선량은 차폐체 미사용 시 44.89 mGy로 측정되었고, bismuth 차폐체는 36.03 mGy, 0.5 mmPb 차폐체는 31.03 mGy, 자체 제작한 1.0 mmPb 차폐체는 23.21 mGy로 측정되었다. 또한, 갑상선의 심부선량은 차폐체 미사용 시 36.10 mGy로 측정되었고, bismuth 차폐체는 34.52 mGy, 0.5 mmPb 차폐체는 32.28 mGy, 자체 제작한 1.0 mmPb 차폐체는 25.50 mGy로 측정되었다. 결 론 : 전뇌 방사선 치료 시 방사선 조사면 밖의 영역에서 발생하는 이차 산란 및 누출 선량에 의해 영향을 받는 갑상선에 대하여 차폐체를 사용했을 때 갑상선 심부는 약 11~30%, 갑상선 표면은 약 20~48% 정도의 피폭선량 감소 효과가 나타났다. 따라서 전뇌 방사선 치료 시 갑상선 차폐체를 사용함으로써 갑상선을 효과적으로 보호하며 치료를 시행할 수 있을 것으로 사료된다.

• 생물정신의학
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• 제26권1호
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• pp.22-31
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• 2019

Objectives Previous studies have revealed inconsistent results on amygdala volume in adult bipolar disorder (BD) patients compared to healthy controls (HC). Since the amygdala encompasses multiple subregions, the subtle volume changes in each amygdala nucleus might have not been fully reflected in the measure of the total amygdala volume, causing discrepant results. Thus, we aimed to investigate volume changes in each amygdala subregion and their association with subtypes of BD, lithium use and clinical status of BD. Methods Fifty-five BD patients and 55 HC underwent T1-weighted structural magnetic resonance imaging. We analyzed volumes of the whole amygdala and each amygdala subregion, including the anterior amygdaloid area, cortico-amygdaloid transition area, basal, lateral, accessory basal, central, cortical, medial and paralaminar nuclei using the atlas in the FreeSurfer. The volume difference was analyzed using a one-way analysis of covariance with individual volumes as dependent variables, and age, sex, and total intracranial volume as covariates. Results The volumes of whole right amygdala and subregions including basal nucleus, accessory basal nucleus, anterior amygdaloid area, and cortico-amygdaloid transition area in the right amygdala of BD patients were significantly smaller for the HC group. No significant volume difference between bipolar I disorder and bipolar II disorder was found after the Bonferroni correction. The trend of larger volume in medial nucleus with lithium treatment was not significant after the Bonferroni correction. No significant correlation between illness duration and amygdala volume, and insignificant negative correlation were found between right central nucleus volume and depression severity. Conclusions Significant volume decrements of the whole amygdala, basal nucleus, accessory basal nucleus, anterior amygdaloid area, and cortico-amygdaloid transition area were found in the right hemisphere in adult BD patients, compared to HC group. We postulate that such volume changes are associated with altered functional activity and connectivity of amygdala nuclei in BD.

• 동의생리병리학회지
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• 제35권2호
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• pp.71-80
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• 2021

Parkinson's disease is one of the typical neurodegenerative disease and it is caused by the destruction of substantia nigra in brain leading to lack of dopamine secretion, and it presents 4 major motor symptoms such as tremor, bradykinesia, stiffness, postural instability. Furthermore, it causes many non-motor symptoms such as anosmia, REM sleep conduct disorder, orthostatic hypotension, dementia and autonomic ataxia such as lack of adjusting blood pressure, hyperhydrosis, constipation. Dopaminergic therapy is the most commonly used strategy, but long term treatment of levodopa induce various adverse effects. Thus, many people are focusing on new therapies other than established therapies, and there are many tries and approaches with paradigm shift. Our medical team was able to get 4 cases of PD patients who are hospitalized in our hospital, treated by Whole Body Gi-Hyeol Therapy consisting of acupuncture therapy, herbal therapy, and mental therapy, and their conditions improved in perspective of Unified Parkinson's Disease Rating Scale(UPDRS), Heart Rate Variability(HRV), and Quality of life. Among all 4 cases, UPDRS score and quality of life score is gotton better, and among 2 cases SDNN, RMS-SD, TP, LF, HF scores are finely increased. And PDQ-39 score which shows quality of life is also improved. However, in spite of these improvements and positive results, there were no meaningful improvement in a hurt from a fall which is important to the aged, muscular atrophy which causes bone fracture and SMI(Skeletal Muscle Mass Index) which is indicator of osteoporosis. Thus, supplementary treatment about Whole Body Gi-Hyeol Therapy such as more active nutrition intervention, safe and effective kinesitherapy is needed, and from now on continuous case reports and systematic clinical research which has control group must be carried out.