• The Journal of Korean Physical Therapy
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• v.23 no.6
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• pp.61-69
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• 2011

Purpose: This study investigated the changes in body composition and serum lipid composition in obese women that were caused by a 12-week circuit exercise regime including both field and aquatic activities. Methods: Subjects comprised a total of 36 women who had a BMI of more than $25kg/m^2$. The simple obesity group (n=17) had no current or past record of medical complications, whereas the group with complications (n=19) also suffered from hypertension and/or diabetes. The circuit exercise program consisted of 12 weeks of 60%HRmax exercise sessions, five days a week. Results: While changes in every variable of body composition were significant, there was no statistically significant difference in the changes in serum lipid composition variables. With the exception of BMI, the correlation between the simple/complicated groups and exercising was statistically insignificant. Conclusion: These findings suggest that while a complex circuit weight exercise program that includes aquatic exercises significantly and positively alters obese patients' body composition it does not create statistically significant changes in their serum lipid composition. It can still be concluded, however, that increasing the duration of the exercise program would be effective to influence this. Moreover, personalized exercise programs that fit the needs of the individual participants seem necessary, given that the effect of exercise on body composition and serum lipid composition was greater in patients with simple obesity than in those with complications.

• Journal of Chest Surgery
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• v.22 no.3
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• pp.436-447
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• 1989

The effect of Glutamate to myocardial toxicity induced by doxorubicin was studied with 20 male rats. 20 rats divided into 4 subgroups, 1st group was taken for normal control group without any treatment, 2nd group was injected with only doxorubicin, 3rd group was injected with L-glutamate and doxorubicin, and 4thd group was injected with only L-glutamate [all injections were done intraperitoneally]. Observations were made to each group on their gross findings, body weight, and electrocardiography, complete blood count and serum level of creatine phosphokinase. The results were as follows; l. In 1st group, we found no changes. 2. In 2nd group, there were many changes which were loss of body weight, dehydration, loss of body hair, diarrhea and death, in addition, elevation of CPK-MB isoenzyme and changes in EKG due to myocardial damage, leukopenia, thrombocytopenia were also found. 3. In 3rd group, there were more toxic effects containing 2 death cases, compared to 2nd group. 4. In 4th group, we found no specific changes except weight gain. These results suggest that L-glutamate which is intermediate of Krebs cycle may worsen the doxorubicin-induced myocardial toxicity.

• Toxicological Research
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• v.15 no.1
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• pp.9-17
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• 1999

This study was performed to evaluate the subacute toxicity of CJ-50002 (Vibrio Vaccine) in SPF Spraqur-Dawley (SD) rats. Vibrio vaccine was administered orally at a dose level of high (167mg/kg/day), medium (16.7mg/kg/day), and low (16.7mg/kg/day) once a day and repeated fro 4 weeks. Ten males and female rats were assigned to each group. After 4 week administration, no significant dose-dependent changes in body weight, water and food consumption rate or organ weight were noted dependent changes in body weight, water and food consumption rate or organ weight were noted among 4 groups. Urinanalysis, hematology, and serum chemistry, also fail to detect any dose-related change among 4 groups tested. During necropsy and histopathological examination, no specific toxicity related to treated material was found. The result of this study demonstrated that vibrio vaccine when administered orally for 4 weeks at a high dose of 167mg/kg/day, no dose-related toxicity was found in treated make and female rats.

• Journal of Nutrition and Health
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• v.27 no.6
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• pp.591-598
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• 1994

The longitudinal changes in transitional milk intakes and body weight of infants(18 boys, 10 girls) have been studied in the part of Kangwon Province from 7 days to 15 days postpartum. Milk intakes at 7, 10, 15 days postpartum were 474$\pm$155, 524$\pm$154 and 547$\pm$130g, respectively. The mean milk intakes were 515g from 7 to 15 days postpartum. Milk intakes of boys were significantly higher than those of girls. The transitional milk intakes per weight of infants appeared 147$\pm$41g/kg. The number of feed per day of boys were significantly higher than those of girls. Milk intakes per fed were 56$\pm$20g. The transitional milk intakes were affected by gestational period(p<0.05), maternal height(p<0.05) and mother's transitional milk yields (p<0.001). Infants transitional milk intakes were 82.6$\pm$17.0% of mothers transitional milk yields. Infants gained its weight 24.6, 40.1 and 39.0g/day at, 7, 10, 15 days postpartum, respectively.

• Journal of Nutrition and Health
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• v.31 no.7
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• pp.1130-1138
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• 1998

The objective of this study was to investigate the relationship between changes in body temperature, adiposity and sympathoadrenal activity in normal weight female college students, eating an instant-noodle lunch in a laboratory setting at ambient temperatures of 22-24.8$^{\circ}C$. Preprandial epinephrine(EPI) concentration, as an indicator of adrenal activity, was inversely and significantly correlated with body weight, body mass index(BMI), and waist girth. Changes in pre- and postprandial EPI concentrations showed positive correlations with % body fat, fat mass, waist girth, hip girth, and waist/hip girth ratio(WHR). The preprandial norepinephrine (NE) concentration was negatively correlated with recovery time from the peak postprandial core temperature to the meal-start core temperature(RTST). However, the NE concentration, an indicator of sympathetic neural activity, was not related to anthropometric measurements in normal weight young women. In conclusion, adrenal activity was negatively associated with adiposity and central body fat distribution. Sympathetic activity was related to body temperature regulation capacity after a meal, but was not related to adiposity in normal weight young women. (Korean J Nutrition 31(7) 1130-1138, 1998)

• Preventive Nutrition and Food Science
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• v.4 no.3
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• pp.197-199
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• 1999

This study was carried out to investigate the effects of garlic vinegar supplementation on changes in body weight, blood glucose and serum triglyceride and cholesterol. Rats were fed a cholesterol-diet with or without garlic vinegar (20% garlic juice )supplement for 28days. Body weights in rats fed a diet containing garlic vinegar were significantly lower than those of control rats. The concentration of plasma glucose, total cholesterol . LDL-cholesterol , and HDL-cholesterol were not significantly different between the two groups for a period of up to four weeks. However, the concentration of plasma triglyceride was slightly decreased in the garlic vinegar-supplemented group. Results suggest that the supplementation of garlic vinegar is beneficial for weight reduction in high-cholesterol fed rats.

• Journal of Nutrition and Health
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• v.31 no.6
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• pp.1057-1065
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• 1998

Anthropometric and body compositional changes and the outcomes of the pregnancies of 90 healthy Korean women were investigated in a longitudinal study. Their weight increased from 51.3$\pm$5.9kg to 65.1$\pm$7.8kg during their pregnancies. The total weight gain was 13.8$\pm$4.5kg, and therefore, weekly weight gain was 340$\pm$110g during the entire period of the pregnancy. The weight gain was composed of approximately 50-60% fat mass and 40-50% fat-free mass. Skinfold thicknesses, both of triceps and subscapular, increased during the pregnancies. The fat mass calculated from skinfold thickness and that measured with bioelectrical impedance analysis went on increasing during the pregnancies. Although there was a considerable difference with respect to the fat mass observed using the three methods, fat mass gain was 5.0-6.1kg and fat-free mass gain was 4.0-5.3kg from the first trimester to the third trimester of pregnancies. There were significant correlations between maternal anthropometric parameters and indices of pregnancy outcomes. Especially, the infant's birth weight was associated with maternal pre-pregnancy weight and weight gains during the pregnancies. The infant's birth length was related to the maternal weight observed at term(p<0.05) and weight gain during the entire pregnancies (p<0.05) . Neither increase of fat mass nor fat-free mass affected the outcomes of pregnancy. These results show that maternal weight gain during pregnancy is led by increments of approximately above 50% fat mass. The fat mass increase seems to be larger in central areas than in subcutaneous areas. Maternal weight gain during pregnancy, especially during late pregnancy, is a factor affecting the birth weight and length of infant. On the basis of the body compositional changes, it can be predicted that the additional energy requirement for pregnancy in Korean women is more than 200-230 MJ (64,500-76,250kca1). (Korean J Nutrition 31(6) : 1057-1065, 1998)

• Journal of Korean Foot and Ankle Society
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• v.4 no.1
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• pp.5-12
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• 2000

Purpose: The purpose of this study is to assess the amount of changes in the foot size on weight bearing in adult women, which might help in choosing an appropriate size of the shoes. Materials and Methods: The authors measured the length and width of the feet of 200 healthy women on weight bearing and non-weight bearing, and the size of the shoes they wore. Results: Foot length and width differences between right and left sides were 2.53 mm and 2.16 mm respectively on non-weight bearing, and 2.47 mm and 1.77 mm respectively on weight bearing. Foot length and width increased by 2.89% and 7.50% respectively on weight bearing than those on non-weight bearing. Shoe width was 6.82% longer and 9.54% narrower than the weight bearing foot size. There were 25 women who had shoe-related foot pain, all of them wore shoes that were 13.01 % or more narrower than the weight bearing foot width. Foot pain was significantly correlated with the shoe-foot width difference(p=0.0001). Conclusion: The foot size was increased by 2.89% in length and 7.50% in width with weight bearing. The width of their shoes was narrower. than the weight bearing foot width. Shoe-related foot pain was correlated with the foot-shoe width difference.

• The Journal of Korean Medicine
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• v.42 no.1
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• pp.46-58
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• 2021

Objectives: The purpose of this study is to report weight changes and analyze adverse events in diabetic patients with Gamitaeeumjowee-Tang for weight loss. Methods: A retrospective chart review of weight change and adverse events was performed during the 10-week weight loss program using Gamitaeeumjowee-tang with low-calorie diets for diabetics(n=61). Weight and BMI changes were compared before and after the program and calculated the percentage of people who lost more than 5% of their weight, also identified whether subjects felt satiated or not. Adverse events were evaluated in terms of causality, severity and system-organ classes. Results: After 10-week weight loss program, significant weight loss (5.9±2.32kg, 7.73% reduction from baseline) and BMI reduction (2.9±0.86) were reported (n=61). Those who lost more than 5 percent of their body weight accounted for 88.5%, and also 88.5% of the participants felt full to help control their appetite. In assessing the causality of adverse events, 'Unlikely' was the most common (66%) and in severity evaluations, almost all symptoms were mild. Insomnia was the most frequently reported during the first 8 weeks, and constipation was reported the most afterwards. Conclusions: A combination of Gamitaeeumjowee-tang and low-calorie diets for 10 weeks appears to help weight reduction without serious adverse events in diabetic patients. Future well-designed prospective clinical studies testing the effectiveness and safety of this weight loss program are warranted.

• Archives of Plastic Surgery
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• v.35 no.4
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• pp.385-392
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• 2008

Purpose: The most effective methods of harvesting, preparing, and injecting autologous fat grafts have been inconsistent and conflicting. With its limitation as resorption in fat grafting, handling various techniques affect adipocyte survival, and is crucial to optimizing its long-term survival. To improve graft survival, re-implantation of cryopreserved adipocytes was developed. In addition, adipocytes do not induce immune rejection in response to non-self lymphocytes in a mixed lymphocyte reaction. The purpose of this study is to analyze the changes in cryopreserved adipocytes so as to determine the most efficient long-term storage period, and to analyze the changes in cryopreserved allografted adipocytes so as to determine the efficacy of cryopreserved adipocytes allografting. Methods: Fat tissues were harvested from the inguinal and retroperitoneal fat pad of mice. After the centrifugation of the harvested fat tissues, they were disintegrated with collagenase. The adipocytes were obtained by centrifugation of the disintegrated fat tissues. The adipocytes were treated as follows: (1) They were examined for weight and then frozen at $-20^{\circ}C$(n=25). For four months, each five frozen samples were taken and examined for weight and histologic changes in the 1st week, the 1st month, the 2nd month, the 3rd month, and the 4th month, respectively. (2) The adipocytes were immediately frozen at $-20^{\circ}C$(n=125). For four months, five frozen samples were taken, and allografted in the same time period as above. Finally, for four months, five cryopreserved allografted adipocytes were taken and examined for histologic changes in the same time period as above. Results: (1) Significant weight changes and histologic findings with inflammatory and destructive changes were observed in the cryopreserved adipocytes in three months. (2) Significant fat necrotic changes in the histologic changes with Hematoxylin and eosin stain were observed in the cryopreserved allografted adipocytes since the first week, independent of the freezing period. Conclusion: The study results show that the adipocytes that were cryopreserved for more than three months underwent obvious weight reductions and necrotic changes, and the adipocytes that were allografted without freezing were viable for four months, but the cryopreserved allografted adipocytes had obvious necrotic changes since the first week regardless of the freezing period.