• 한국산학기술학회논문지
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• 제18권1호
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• pp.545-552
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• 2017

함몰은 싱크홀, 포트홀, 구조물 침하, 도로함몰 등을 발생시킨다. 도로함몰은 지표수 근처 석회암이 녹아 동공이 생기고 지지력 저하로 인한 도로표면의 급작스런 붕괴로 기술된다. 도로함몰은 서울시에서만 2010년 이후 연평균 약 665건 발생하였고 2013년까지는 발생빈도가 증가하였다. 서울 지역에서 발생하는 도로함몰의 주된 원인은 지하 시설물의 파손 및 관리 소홀과 지하수위 강하 등이다. 이에 서울시에서는 여러 기관과 공동연구 및 탐사를 통해 원인을 규명하고 통행자들이 안심할 수 있도록 안전관리방안에 대한 특별대책을 수립하여 발표하였다. 도심지의 경우 주로 굴착복구 공사에서 도로함몰이 발생할 수 있기 때문에 공사장에서의 올바른 관리는 필수적이다. 본 연구의 목적은 도로함몰의 주된 원인을 파악하고 이에 대한 대책 및 관리방안을 제시하는 것이다. 이를 위하여 생애주기비용 분석을 통해 주야간공사 시행의 필요성을 제기하였다. 또한 모래를 뒤채움재로 사용하는 경우의 한계점을 분석하여, 모래 대신 유동성 뒤채움재를 활용할 것을 제안하였다. 마지막으로 지방자치단체들의 도로탐사 사각지대를 줄이기 위하여, 권역으로 구분하고 권역별로 외부전문기관과 협업하여 탐사하는 방안을 제시하였다.

• Nutrition Research and Practice
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• 제12권5호
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• pp.378-386
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• 2018

BACKGROUND/OBJECTIVES: Benign prostatic hypertrophy (BPH) is a major cause of abnormal overgrowth of the prostate mainly in the elderly. Corni Fructus has been reported to be effective in the prevention and treatment of various diseases because of its strong antioxidant effect, but its efficacy against BPH is not yet known. This study was designed to evaluate the therapeutic efficacy of Corni Fructus water extract (CF) in testosterone-induced BPH rats. MATERIALS/METHODS: To induce BPH, rats were intraperitoneal injected with testosterone propionate (TP). Rats in the treatment group were orally administered with CF with TP injection, and finasteride, which is a selective inhibitor of $5{\alpha}$-reductase type 2, was used as a positive control. RESULTS: Our results showed that the increased prostate weight and histopathological changes in BPH model rats were suppressed by CF treatment. CF, similar to the finasteride-treated group, decreased the levels of testosterone and dihydrotestosterone by TP treatment in the serum, and it also reduced $5{\alpha}$-reductase expression and concentration in prostate tissue and serum, respectively. In addition, CF significantly blocked the expression of the androgen receptor (AR), AR co-activators, and proliferating cell nuclear antigen in BPH rats, and this blocking was associated with a decrease in prostate-specific antigen levels in serum and prostate tissue. CONCLUSIONS: These results suggest that CF may weaken the BPH status through the inactivation of at least $5{\alpha}$-reductase and AR activity and may be useful for the clinical treatment of BPH.

• 한국조경학회지
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• 제34권3호
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• pp.120-138
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• 2006

A city evolves over time. It grows, transforms, and sometimes degrades. Chuncheon is at a turning point from a city souggling with regulations regarding clean water supply and a military encampment to a masterpiece city with a sustainable vision. The city is getting ready to restructure itself to become a world-famous culture and tourism complex expanding its physical boundary across the Camp Page site and absorbing Jungdo as a major tourist attraction. The landscape in the future blueprint of Chuncheon will play a great role in restructuring urban form. The regenerated in will have a new networked open space system as well as re-evaluated landscape resources. The hybrid theoretical practice called 'landscape urbanism' burgeoning in the fields between 'landscape architecture' and 'urbanism' can guide us in considering the terms of the relationship between a city and landscape when we design a future city Landscape urbanism is considered to be an effective framework by which we can diagnose the current status of a landscape in our contemporary urban design practice in Korea. This paper tries to provide a different perspective from the viewpoint of landscape urbanism to decipher the hidden implications of the social agreement on the role of landscape in urban structure by re-reading eight design proposals presented for the ChunCheon G5 international design competition based on the main principles of landscape urbanism. The G5 design competition is a great opportunity to test out new ideas on a city, demonstrating the relative values among various urban-design professional realms. First, this paper provides an overview of the main ideas of landscape urbanism based on the literature review and case studies. Second, framework categories are suggested in order to extract the explicit and implicit ideas on the landscape. Third, eight proposals are reviewed according to the suggested categories to situate the current landscape design of Korea within the mainstream of contemporary practice of landscape urbanism. Based on the review of eight proposals, the following diagnostic conclusions are made; first, the ideas of landscape urbanism have not been actively introduced in large-scaled urban landscape projects in Korea like Chuncheon G5. Second, it remains to be a big task for landscape professions to be able to participate in design consortiums on an equal footing. Third, In order to introduce and reify the ideas of landscape urbanism in Korea, it is inevitable and critical to test the ideas in both academic fields and professional practices to find the appropriately adjusted model of landscape urbanism.

• 한국항해항만학회지
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• 제30권6호
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• pp.447-455
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• 2006

근래 국내 산업의 고도화와 수출입 증가에 따른 경제력의 상승과 함께 도로, 교량 및 항만시설의 확충과 각종 호안 및 해상구조물의 건설요구가 급증하고 있다. 해양수산부는 9대 신항만의 건설과 기존어항의 재개발을 추진하고 있다 이들 구조물의 대부분은 교각기초, 안벽, 돌핀, 안벽, 돌제 등은 강재나 콘크리트 파일로 새롭게 건설되고 있다. 이들 기초, 지지격벽 및 파일은 건설 후에 수면아래에 있게 되므로 구조물의 상태를 파악하기가 어렵고, 그 구조물의 보수나 보강이 충분하지 못한 상태이다. 더구나 매년 이러한 유지 보수작업은 구조물의 부식을 방지하기 위한 불완전한 보수와 수중공사로 인한 장기작업으로 고비용 때문에 정부의 예산을 소진하게 된다. 이와 같은 정부예산의 지출을 절감하기 위해서는 기존 구조물의 내구연한을 연장시킬 필요가 있는 것이다. 그러므로, 부유식 케이슨으로 건식작업환경을 제공함으로써 평균해수면 수중구조물의 유지를 위한 새로운 기법을 개발하였다. DCPM은 작업구간을 쉽게 이동하고 취급이 용이한 것으로 나타났다. 또한 DCPM은 유지보수비용 및 방식작업 시간을 현저하게 줄였다. DCPM은 해안 및 수중구조물의 유지와 건설비용을 줄이는 이정표가 될 것으로 본다.

• Journal of Nutrition and Health
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• 제29권8호
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• pp.849-860
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• 1996

The supply of different fatty acids during the development period has significant effects. This study examined the effects of dietary $\omega$3 and $\omega$6 fatty acid compositions on phospholipids (PLs) of RBC and rat brain subcellular fractions (synaptosome, microsome, mitochondria), and on learning ability of the 2nd generation rat. Rats were fed experimental diets 3-4 wks prior to the conception. Early in the lactation period, the feeding mothers were exchanged. Diets consisted of 10% fat(by weight), which was either safflower oil('S') poor in $\omega$3 fatty acids or computer-searched mixed oil('M') with P/M/S ratio, 1/1.4/1 and $\omega$6/$\omega$3 ratio, 6.1/1. The 'S' and 'M' rats were subdivided further into SS, SM, MS & MM rats according to their lactation stauts. At 3 (weaning) & 9 wks of age, the percentage of total $\omega$3 fatty acids to their lactation status. At 3 (weaning) & 9 wks of age, the percentage of total $\omega$3 fatty acids and the ratios of $\omega$3/$\omega$6 fatty acids in PLs of RBC and brain subcellular fractions in SM and MM groups fed milk from the mixed oil-fed mothers for 2 wks tended to be higher than those in SS and MS groups respectively. In contrast, the concentrations of $\omega$6 fatty acids, especially 22:5$\omega$6 in all fractions, were significantly lower in the SM & MM groups compared to those of the SS & MS groups respectively. In contrast, the concentration of $\omega$6 fatty acids, especially 22:5$\omega$6 in all fractions, were significantly lower in the SM & MM groups compared to those of the SS & MS groups, The values for the DHA$\omega$3/22:5$\omega$6 ratios after the lactation period were markedly higher in the groups (SM & MM) which were reared by mixed oil(MO) fed mothers. In carring out Y-water maze at 9th wk of age, the SM(4.2$\pm$0.5) & MM (5.3$\pm$0.5) groups made significantly less errors compared to the SS(6.2$\pm$0.6, p<0.05 compared with SM) & MM (7.2$\pm$0.5, p<0.05 compared with MM) groups which were lactated by the safflower oilfed mothers. Therefore, by feeding a balanced fatty acid diet from the lactation period up to 9 wks of age as compared with the groups fed $\omega$3 fatty acid-deficient diet regardless of mother's diet given before parturition. The levels of DHA(synaptosome) and 22:5$\omega$3 (mitochondria) were positively correlated not only with these values in RBC but also with visual discriminating ability. The levels of DHA and 22:5$\omega$3 in RBC can, therfore, reflect visual discriminatng ability in the rat.

• 대한원격탐사학회지
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• 제33권2호
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• pp.231-242
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• 2017

시설물의 장기적이고 지속적인 사용을 위해서 모니터링은 중요하다. 특히, 도로, 댐, 교량 등의 시설물은 안전과 비용의 문제로 자주 점검하기 어렵다. 이러한 문제에 대한 효율적이고 경제적인 대안으로 스마트폰 기반 모니터링을 고려할 수 있다. 시설물 모니터링을 위해 스마트폰 영상을 정량적으로 분석하기 위해서, 먼저 절대좌표계를 기준으로 보정해야 한다. 본 연구는 임의의 위치에서 취득된 스마트폰 영상을 기준영상을 기반으로 보정하여 시설물 모니터링에 활용하는 방법을 제시한다. 기준영상을 활용하여 지오레퍼런싱을 수행하여 스마트폰의 외부표정요소를 결정한다. 이를 이용하여 스마트폰 영상을 시설물의 대상 객체면에 투영하여 보정한다. 제안된 방법은 보에서 취득한 시험데이터에 적용하였다. 스마트폰의 외부표정요소는 위치 5 cm, 자세 $0.28^{\circ}$ 정확도로 결정되었다. 보정된 스마트폰 영상에서 측정한 길이는 10 cm의 오차를 보였다. 제안된 방법을 이용하여 스마트폰 영상을 시설물 모니터링에 효과적으로 활용할 수 있을 것으로 기대된다.

• 대한수의학회지
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• 제48권3호
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• pp.337-345
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• 2008

There are accumulating evidences that high levels of dietary iron may play a role in colon carcinogenesis. Elevated iron status has been associated with oxidative stress. Phytic acid (PA) functions as an antioxidant by chelating divalent cations and prevents formation of reactive oxygen species responsible for cell injury and carcinogenesis. The protective effect of PA was investigated on formation of aberrant crypt foci (ACF) induced by azoxymethane (AOM) in iron-overloaded male F344 rats. After acclimation with AIN-93G purified diet (35 ppm Fe, normal control diet) for one week, animals were fed iron-overloaded diet (350 ppm Fe) and PA (0.5% or 2% PA in water) for 8 weeks. Animals received two (1st and 2nd week) injections of AOM (15 mg/kg b.w.) to induce colonic ACF. The colonic mucosa was examined for the total numbers of aberrant crypt (AC) and ACF after staining with methylene blue. The blood and serum were analyzed with a blood cell differential counter and an automatic serum analyzer. Iron-overloaded diet increased the concentration of iron in liver of the rats. But iron-related parameters in blood were not changed among experimental groups. The numbers of ACF per colon and AC per colon were $178.8{\pm}33.2$ and $448.4{\pm}110.2$ in the iron-overloaded F344 rats. The total AC was significantly increased, compared with normal-diet AOM control group (p < 0.05). The treatments of PA at the dose of 0.5% slightly decreased the number of ACF and AC per colon to $153.6{\pm}29.5$ and $396.3{\pm}107.5$. However, there were no significant differences in the total numbers of ACF and AC between the AOM control group and PA (0.5% or 2%)-treated groups. These results suggest that PA may not affect the formation of ACF or AC induced by AOM in ironoverloaded F344 rats.

• 농촌의학ㆍ지역보건
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• 제21권2호
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• pp.221-230
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• 1996

This study was purposed to develop the fluoride mouthrinsing project through the public health system in a rural area. This project was performed under the management of the public health dentist for the 3rd grade students selected from the 5 primary schools at Goksunggun in Chonnam area. Fluoride mouthrinsing was executed with 0.2% neutral sodium fluoride solution once a week. After 1 year's fluoride mouthrinsing project, DMFT index, DMF rate frequencies of toothbrushing, simplified oral hygiene index, and the responses to fluoride mouthrinsing project of the school children participated were examined. The results obtained from this study were as follows: 1. The fluoride mouthrinsing project for school children was performed average 10 times a year by the public health dentist. They were relatively little active to perform this project. 2. There was no significant difference in the increasement of DMFT index and DMF rate during 1 year between control and fluoride mouthrinsing group. 3. Control group was increased higher than fluoride mouthrinsing group in simplified oral hygiene index. 4. Toothbrushing frequencies increased in both groups. 5. 80.4% of school children participated in fluoride mouthrinsing project was responded to like it, and 78.2% among them was responded the project to be beneficial for their dental health. 6. 39.2% of school children was responded to have water-like taste for fluoride solution. But 34.0% of them was done to have strange taste. On consideration of above findings, this fluoride mouthrinsing project was not well performed by the public health dentists and also the oral health status of school children participated was not significantly improved by this project. Therefore, to perform continually this project well, it was recommended that this project should be performed by other person such as dental hygienist rather than public health dentist.

• 생명과학회지
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• 제20권8호
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• pp.1249-1253
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• 2010

Sericin은 실크를 싸고 있는 고분자 수용성 당단백질로서 세포배양에 사용되며 세포분화를 촉진한다. 본 연구의 목적은 갑상선세포(FRTL-5)에서 thyroglobulin (Tg)의 분비에 sericin이 영향을 주는지를 알려고 한다. Sericin에 의해서 Tg의 분비가 촉진되었지만 Tg-mRNA의 발현은 촉진되지 않았다. 이런 상태에서 소포체 샤페론(Bip & calreticulin)과 소포체 막 단백질(IRE1, PERK & ATF6)의 발현이 증가한 것이 확인되었다. 한편 IRE1의 하부 신호전달자인 XBP1의 mRNA splicing 이 약하게 확인되었지만 PERK의 하부 신호전달자인 $eIF2{\alpha}$의 인산화는 일어나지 않았다. 그리고 sericin은 MTT assay 결과 cell viability을 촉진시키는 것도 확인되었다. 위의 결과는 sericin은 재조합 단백질생산에 유용하게 이용될 수 있는 새로운 생체물질로 증명되었다.

• 한국식품영양과학회지
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• 제41권10호
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• pp.1454-1459
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• 2012

섬유소 식품 중 바질과 정향의 방사선 조사처리 여부 확인을 위한 전자스핀공명분석법(ESR)의 개선을 위해 동결건조(FD), 상압건조(OD), 알코올건조(AE), 알코올세척건조(WAE) 처리하여 cellulose radical을 확인하였다. 비 조사 시료는 모두 singlet signal($g_0$=2.006)을 나타내었고, 조사된 시료의 경우는 모두 singlet signal을 중심으로 두 개의 side peak($g_1$=2.023 and $g_2$=1.986)가 6 mT 간격으로 나타나 cellulose 유래의 signal을 확인할 수 있었다. AE, WAE 처리한 정향의 경우, 조사유래의 cellulose radical의 ESR intensity가 증가하였으며, central peak와 side peak의 비율도 판별에 매우 적합하였다. 그러나 FD 처리한 바질의 경우 ESR intensity는 가장 크게 나타났으나, signal ratio는 AE, WAE 처리하였을 때 더 이상적이었다. 또한 $Mn^{2+}$ signal 유래의 radical은 AE, WAE 처리한 시료에서 크게 감소하여, FD 및 OD에 비해 매우 명확한 조사여부 판별이 가능하였다. 따라서 AE, WAE 처리는 바질과 정향의 조사여부 판별방법을 크게 개선시키는 것으로 확인되었으며, 기타 향신료에 대해서도 ESR spectra 분석에 적용 가능할 것으로 판단되었다.