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Bioavailability of Emulsion Containing Scutellariae Radix Extract (황금 엑스 유제의 생체이용률)

  • Yang, Jae-Heon;Kim, Young-Il
    • Journal of Pharmaceutical Investigation
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    • v.29 no.1
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    • pp.1-5
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    • 1999
  • The bioavailabilities of baicalin in water, oil, w/o and o/w emulsion were evaluated in rats. The dissolution rate of baicalin in o/w emulsion was smaller than those of w/o form in dilute hydrochloric acid solution (pH 1.2) and in PBS (pH 6.8). The absorption rate of baicalin from w/o emulsion was smaller than that of o/w emulsion in the different parts of rat intestine of the rats. Following oral administration in rats, the $C_{max}$ of baicalin from water phase, oil phase, o/w wand w/o emulsion were 2.11, 0.61, 1.57, and $1.35\;{\mu}g/ml$, respectively. The relative bioavailability of w/o emusion was 129 % when it was compared with water phase. This result suggests that the improvement of bioavailability for baicalin in w/o emulsion might be practically available.

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Research Trends and Development Prospects of Realistic Media S/W (실감미디어 S/W의 연구 동향과 발전 전망)

  • Lee, Jong-Hoon;Min, Byoung-Won;Oh, Yong-Sun
    • Proceedings of the Korea Contents Association Conference
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    • 2011.05a
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    • pp.71-72
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    • 2011
  • 소프트웨어는 컴퓨터 및 시스템에 탑재되어 제품 및 서비스의 부가가치를 높이고 기업과 개인의 경쟁력을 향상시키는 핵심 기술로 국가 미래 산업 경쟁력의 원천이며, 기기 서비스 사람을 연결하는 산업 성장 엔진으로 임베디드 S/W, 시스템 S/W, 온라인 서비스 S/W, 지능형 S/W, 실감미디어 S/W로 분류가 되는데 이중에서 실감미디어 S/W는 미디어의 사실적인 표현 및 현장감 재현, 체험 공간 참여가 가능하도록 지원하는 S/W로서, 지능형 영상처리기술, 인터랙션기술 및 시뮬레이션 기술 등으로 구성된다. 단방향적인 시청각 서비스를 통한 감동전달 미디어 서비스에서 고품격의 미디어 서비스와 다양한 감각 기술을 활용한 혁신적이고 인간 친화적인 체감형 인터랙션 기술을 활용하여 미디어의 현실감을 극대화할 수 있는 실감미디어 S/W에 대한 국내외 기술의 개발 동향, 정책 동향, 사업 동향, 그리고 표준화 동향에 대해 고찰하고 발전 전망에 대해 논하고자 한다.

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A study fo Al/W(110) surface structure at various annealing temperature and coverage

  • Choe, Dae-Seon;Park, Min-Geol;Park, Mi-Mi;Lee, Jeong-Hwan;Kim, Ju-Hwan;Kim, Do-Hyeong
    • Proceedings of the Korean Vacuum Society Conference
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    • 2011.02a
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    • pp.344-344
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    • 2011
  • W(110)면에 흡착원자인 Al원자의 coverage와 annealing과정에서의 온도를 변화시켜, 여러 조건에서의 Al/W(110)계의 흡착구조를 저에너지 전자회절(LEED)과 이온산란분광법(ISS-TOF)을 이용하여 연구하였다. 여러 결과 중, annealing 온도가 900K인 1.0ML Al/W(110)면은 double domain의 p($1{\times}1$)의 흡착구조로 W(110)면의 center of hollow site에서 $0.55{\AA}$ 벗어난 위치에 흡착되었으며, W(110) 표면원자로부터 Al 원자까지의 높이는 $2.13{\pm}0.15{\AA}$이다. 또한 annealing 온도가 1100K인 0.5ML Al/W(110)면은 double domain의 p($2{\times}1$)의 흡착구조로 W(110)면의 center of bridge site에 흡착되었으며, W(110) 표면원자로부터 Al 원자까지의 높이는 $2.18{\pm}0.15{\AA}$이다.

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A Study on the Life Time Broadening of Die parts Manufactured in W-EDM (W-EDM에 의한 금형제작에서의 수명연장에 관한 연구)

  • Kim Sei-hwan
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.5 no.6
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    • pp.511-514
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    • 2004
  • Punch and die plate which are press die parts can be made using machine tool or using both machine tool and W-EDM. When machine tool is used, the die life is 2,000,000 to 230,000 strokes. But with W-EDM, the die life is 700,00 to 800,000 strokes. This can be caused by the process deformation layer after W-EDM. SEM pictures of processed section before and after W-EDM are taken to see if the process deformation layer appeared. Also the elimination method is studied.

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Some Remarks on the s-plane to w-plane Correlations of w-transform (w-변환의 s와 w영역간의 관계에 대한 유의 성질)

  • Jin, Lihua;Kim, Young-Chol
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.61 no.1
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    • pp.117-124
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    • 2012
  • In this paper, we present some remarks on the correlations between s and w domains when a discrete-time transfer function is converted from z-plane by using the w-transform. With time response specifications, when a digital filter or controller is designed in z-plane, the w-transform is useful for the purpose if only the w-transformed system closely approximates to the continuous-time system. It will be shown that the approximation is accomplished only in the specific region depending on sampling time. Also, it is noted that such an approximation should be carefully dealt with for the case where a discrete-time reference transfer function is synthesized for the use of direct digital design.

Extraction of Quality Attribute for Designing the S/W Architecture in Weapon Systems Embedded Software (무기체계 임베디드 S/W 아키텍처 설계를 위한 품질속성 추출)

  • Im, Jong-Sam;Yun, Hui-Byeong
    • Proceedings of the Korean Institute of Intelligent Systems Conference
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    • 2006.11a
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    • pp.268-271
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    • 2006
  • 본 논문은 S/W 아키텍처 일반 모델 및 무기체계 S/W 특징을 분석하여 무기체계 S/W 품질속성을 추출한다. 이를 위해 먼저 4+1 View 모델, SEI 모델, Siemens 모델, RM-ODP 모델, Rational ADS 모델을 분석하고 무기체계 임베디드 S/W 특징을 분석하여 품질속성을 추출한다. 그런 다음 품질속성 측정매트릭스를 작성하여 품질속성 추출자료를 매핑하고 최종적으로 필수 이해당사자 관점에서 최종 평가하여 무기체계 S/W 품질속성을 추출한다.

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A Method for One-Click Installing and Executing Web Applications (웹 애플리케이션의 원클릭 설치 및 실행 방법)

  • Nam, Ki-Hyuk;Ku, Kyung-I;Kang, Sung-Ju;Kim, Won-Young;Choi, Wan
    • Proceedings of the Korea Information Processing Society Conference
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    • 2007.11a
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    • pp.479-481
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    • 2007
  • 본 논문에서는 데스크탑 사용자가 손쉽게 웹 애플리케이션을 설치하고 실행하기 위한 원클릭 배포방식을 소개한다. 먼저 기존 웹 애플리케이션의 배포 방식의 현황 및 문제점을 제시하고, 이를 해결하기 위한 웹 애플리케이션의 패킹 및 실행 메커니즘과 관련 구성 요소를 소개한 뒤, 구현 결과와 향후 과제를 제시한다.

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Quality Characteristics of Salt-Fermented Anchovy Sauce and Sandlance Sauce (멸치액젓 및 까나리액젓의 품질 특성)

  • OH Kwang-Soo
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.32 no.3
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    • pp.252-255
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    • 1999
  • The quality characteristics of the Korean traditional salt-fermented fish sauces, the traditional anchovy sauce (TAS) and the sandlance sauce(TKS) were evaluated comparing to the commercial anchovy sauce (CAS) and sandlance sauce (CKS). The acidity was higher in TKS than in TAS, whereas the contents of VBN, total-N and amino-N were higher levels in TAS. In color values, L and b values in TAS were generally higher than those in TKS, whereas a and ${\Delta}E$ values were higher in TKS. The contents of total free amino acids in TAS and TKS were $12.40\;g\%$ (w/v) and $9.549 g\%$ (w/v), respectively. The contents or six amino acids, alanine, glutamic acid, leucine, isoleucine, valine and Iysine were higher in TAS, whereas the contents of arginine, glutamic acid, leucine, alanine and valine were higher in TKS. Nucleotides such as IMP and hypoxanthine were principal components in both TAS and TKS. The nitrogen related compounds, TMAO, TMA and total creatinine were determined to be $108.8\;mg\%$ (w/v), $60.5\;mg\%$ (w/v), $62.4\;mg\%$ (w/v) in TAS, and those in TKS were $60.1\;mg\%$ (w/v), $24.1\;mg\%$ (w/v), $67.6\;mg\%$ (w/v), respectively.

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Response of File Fish to the Attraction Lamp (유도등에 대한 말쥐치의 반응)

  • An, Yeong-Il;Yang, Yong-Rim
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.23 no.4
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    • pp.169-176
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    • 1987
  • The response of file Navodon modestus (GUNTHER) to attraction lamps in line and an adaptation lamp was carried out in the experimental water tank (550L$\times$58W$\times$73H cm). The rate of attraction was investigated in accordance with the intervals of time lighted on and off (1, 5, 10 minute), the intensities of adaptation lamp (1, 10, 20 W) and the two conditions of light stimulus which were the movement of lighted zone (NORMAL) and decrement of lighted zone (NEGA). The results are as follows: 1. Under Normal condition, the variation coefficients which show variation of attraction rate according to the time intervals and the intensities of adaptation lamps were 16.78% (1 min.), 9.71% (5 min.), 8.96% (10 min.), 9.71% (1 W), 15.00% (10W) and 21.08% (20 W) respectively, and attraction rates of the last section was 80.0% (1 min.), 86.0% (5 min.), 85.0% (10 mim.), 86.0% (1 W), 78.7% (10W) and 72.7% (20 W) respectively. 2. Under Nega condition, the file fish was almost distributed all in the illuminated sections, and the majority of the distribution section was adjacent to the extinguished section regardless of the time intervals and the adaptation lamps. 3. Under Nega condition, the variations of attraction rate in the last section became L type, and the attraction rates, when the rest except for the last attraction lamp was extinguished, were 96.7% (1 min.), 100% (5 min.), 96.0% (10 mim.), 100% (1 W), 100% (10W) and 88.0% (20 W) respectively.

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Alteration of Forearm Local Temperature and Median Nerve Conduction Velocity by Therapeutic Ultrasound in Healthy Adult Subjects (초음파에 의한 전완 국소 온도와 정중 운동 신경전도 속도의 변화)

  • Jeon, Cha-Sun;Kim, Taek-Yean
    • The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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    • v.12 no.1
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    • pp.37-43
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    • 2006
  • PURPOSE: Previous studies have documented the lack of ultrasound's non-thermal effects on nerve conduction using frequencies of 1 MHz and 870 kHz. The purpose of this study was to determine the biophysical effects of continuous ultrasound on median local forearm temperature and motor nerve conduction velocities using frequencies of 3.0 MHz. SUBJECTS: Twelve healthy subjects (6 males, 6 females, age $22.30{\pm}2.41$ yrs, weight $61.33{\pm}10.16$ kg, height $167.58{\pm}8.04$ cm) without a history of neurological or musculoskeletal injury to their dominant arm volunteered for this study. METHODS AND MATERIALS: Each subject received a total of five treatments, one each at .0, 0.5, 1.0, 1.5, 2.0 W/$cm^2$ of 3 MHz continuous ultrasound on the anterior surface of the middle area of dominant forearm for 10 minutes. Dependent measures for forearm local temperature and median motor nerve conduction velocity (MNCV) were taken pretreatment and immediately post-treatment. One-way ANOVA were used for each dependent measure. RESULTS: The posttreatment forearm local temperature were differed significantly (p<0.001) between intensities of ultrasound. The posttreatment forearm local temperature of the ultrasound treated with 1.0 w/$cm^2$, 1.5 w/$cm^2$ and 2.0 w/$cm^2$ were significantly higher than 0.5 w/$cm^2$ and 0.0 w/$cm^2$ of ultrasound (p<0.05). The posttreatment median MNCV were differed significantly from the respective pretreatment velocities (p<0.001). The MNCV of the ultrasound treated with 0.0 w/$cm^2$ and 0.5 w/$cm^2$ were significantly (p<0.05) slower than that observed pretreatment, while the three ultrasound intensities produced significantly increased posttreatment MNCV: 1.0 w/$cm^2$ and 1.5 w/$cm^2$ and 2.0 W/$cm^2$. The posttreatment MNCV at 2.0 w/$cm^2$ and 1.5 w/$cm^2$ was significantly faster than that at 0 w/$cm^2$, 0.5 w/$cm^2$ and 1.0 w/$cm^2$ (p<0.05), the MNCV at 1.0 w/$cm^2$ was significantly faster than that associated with 0 w/$cm^2$ and 0.5 w/$cm^2$ of ultrasound (p<0.05). CONCLUSIONS: The decreased median motor forearm local temperature and MNCV of the ultrasound treated with 0.0 w/$cm^2$ and 0.5 w/$cm^2$ were attributed to the cooling effect by ultrasound transmission gel. Local forearm temperature and nerve conduction velocity were directly related to the intensity of ultrasound. Alterations in MNCV from ultrasound on healthy nerves appeared to be related to temperature changes induced by thermal effects of ultrasound.

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