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Comparison of Anisotropic Analytic Algorithm Plan and Acuros XB Plan for Lung Stereotactic Ablative Radiotherapy Using Flattening Filter-Free Beams (비편평화여과기 빔을 이용한 폐 정위절제방사선치료를 위한 AAA와 Acuros XB 계산 알고리즘의 치료계획 비교)

  • Chung, Jin-Beom;Eom, Keun-Yong;Kim, In-Ah;Kim, Jae-Sung;Lee, Jeong-Woo;Hong, Semie;Kim, Yon-Lae;Park, Byung-Moon;Kang, Sang-Won;Suh, Tae-Suk
    • Progress in Medical Physics
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    • v.25 no.4
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    • pp.210-217
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    • 2014
  • This study investigated the dosimetric effects of different dose calculation algorithm for lung stereotactic ablative radiotherapy (SABR) using flattening filter-free (FFF) beams. A total of 10 patients with lung cancer who were treated with SABR were evaluated. All treatment plans were created using an Acuros XB (AXB) of an Eclipse treatment planning system. An additional plans for comparison of different alagorithm recalcuated with anisotropic analytic algorithm (AAA) algorithm. To address both algorithms, the cumulative dose-volume histogram (DVH) was analyzed for the planning target volume (PTV) and organs at risk (OARs). Technical parameters, such as the computation times and total monitor units (MUs), were also evaluated. A comparison analysis of DVHs from these plans revealed the PTV for AXB estimated a higher maximum dose (5.2%) and lower minimum dose (4.2%) than that of the AAA. The highest dose difference observed 7.06% for the PTV $V_{105%}$. The maximum dose to the lung was also slightly larger in the AXB plans. The percentate volumes of the ipsilateral lung ($V_5$, $V_{10}$, $V_{20}$) receiving 5, 10, and 20 Gy were also larger in AXB plans than for AAA plans. However, these parameters were comparable between both AAA and AXB plans for the contralateral lung. The differences of the maximum dose for the spinal cord and heart were also small. The computation time of AXB plans was 13.7% shorter than that of AAA plans. The average MUs were 3.47% larger for AXB plans than for AAA plans. The results of this study suggest that AXB algorithm can provide advantages such as accurate dose calculations and reduced computation time in lung SABR plan using FFF beams, especially for volumetric modulated arc therapy technique.

Dosimetric Advantages of the Field-in-field Plan Compared with the Tangential Wedged Beams Plan for Whole-breast Irradiation (유방암 환자의 방사선치료에 있어서 순치료계획 세기변조방사선치료법과 쐐기접선조사기법의 선량측정 비교)

  • Kim, Suzy;Choi, Yunseok
    • Progress in Medical Physics
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    • v.25 no.4
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    • pp.199-204
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    • 2014
  • The purpose of this study is to evaluate the dosimetric outcome of the field-in-field (FIF) plans compared with tangential wedged beams (TWB) plans for whole breast irradiation of breast cancer patients. Twenty patients with right-sided breast cancer and 10 patients with left-sided breast cancer were retrospectively enrolled in this study. We generated a FIF plan and a TWB plan for each patient to compare dosimetric outcomes. The dose the homogeneity index (HI), the conformity index (CI) and the uniformity index (UI) were defined and used for comparison of the dosimetric outcome of the planning target volume (PTV). To compare the dosimetric outcome of the organs at risk, the mean dose ($D_{mean}$) and the percentage of volumes receiving more than 10, 20 and 30 Gy of the ipsilateral lung and heart were used. The FIF plans had significantly lower HI (p=0.002), higher UI (p=0.000) and CI (p=0.000) than those of the TWB plans, which means that the FIF plans were better than the TWB plans in the dosimetric comparisons of the PTV. The $V10_{lung}$ ($17.1{\pm}7.1$ vs. $18.6{\pm}6.6%$, p=0.020) and $V30_{lung}$ ($10.3{\pm}5.1%$ vs. $10.7{\pm}5.2%$, p=0.000) were lower with the FIF plans compared with those of the TWB plans, with statistical significance. For the left-sided breast cancer patients, $D_{mean}$ of the heart ($2.6{\pm}1.3$ vs. $3.2{\pm}1.4$ Gy, p=0.000), $V20_{heart}$ ($3.4{\pm}2.6$ vs. $3.6{\pm}2.8%$, p=0.005) and $V30_{heart}$ ($2.6{\pm}2.3%$ vs. $2.9{\pm}2.4%$, p=0.004) were significantly lower for the FIF plans in comparison with those of the TWB plans. The FIF plans increased the dose homogeneity, conformity and uniformity of the target volume for the whole-breast irradiation compared with the TWB plans. Moreover, FIF plans reduced the doses to the ipsilateral lung and heart.

The Feasibility Study of MRI-based Radiotherapy Treatment Planning Using Look Up Table (Look Up Table을 이용한 자기공명영상 기반 방사선 치료계획의 타당성 분석 연구)

  • Kim, Shin-Wook;Shin, Hun-Joo;Lee, Young-Kyu;Seo, Jae-Hyuk;Lee, Gi-Woong;Park, Hyeong-Wook;Lee, Jae-Choon;Kim, Ae-Ran;Kim, Ji-Na;Kim, Myong-Ho;Kay, Chul-Seung;Jang, Hong-Seok;Kang, Young-Nam
    • Progress in Medical Physics
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    • v.24 no.4
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    • pp.237-242
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    • 2013
  • In the intracranial regions, an accurate delineation of the target volume has been difficult with only the CT data due to poor soft tissue contrast of CT images. Therefore, the magnetic resonance images (MRI) for the delineation of the target volumes were widely used. To calculate dose distributions with MRI-based RTP, the electron density (ED) mapping concept from the diagnostic CT images and the pseudo CT concept from the MRI were introduced. In this study, the look up table (LUT) from the fifteen patients' diagnostic brain MRI images was created to verify the feasibility of MRI-based RTP. The dose distributions from the MRI-based calculations were compared to the original CT-based calculation. One MRI set has ED information from LUT (lMRI). Another set was generated with voxel values assigned with a homogeneous density of water (wMRI). A simple plan with a single anterior 6MV one portal was applied to the CT, lMRI, and wMRI. Depending on the patient's target geometry for the 3D conformal plan, 6MV photon beams and from two to five gantry portals were used. The differences of the dose distribution and DVH between the lMRI based and CT-based plan were smaller than the wMRI-based plan. The dose difference of wMRI vs. lMRI was measured as 91 cGy vs. 57 cGy at maximum dose, 74 cGt vs. 42 cGy at mean dose, and 94 cGy vs. 53 at minimum dose. The differences of maximum dose, minimum dose, and mean dose of the wMRI-based plan were lower than the lMRI-based plan, because the air cavity was not calculated in the wMRI-based plan. These results prove the feasibility of the lMRI-based planning for brain tumor radiation therapy.

A Study on Christian imagination of the Modern Sijo - On Seon, Jeong-ju and Jang, Sun-ha - (현대시조의 기독교적 상상력 연구 - 선정주·장순하 시조를 중심으로 -)

  • Min, Byeong-Kwan
    • Sijohaknonchong
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    • v.43
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    • pp.149-175
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    • 2015
  • There have been few researches about Christian imagination reflected in modern sijo. The purpose of this study was to provide basic information helpful to deeply understand Christian literature and clarify the history of Christian sijo literature. For this purpose, the study focused on pieces of sijo written by Seon Jeong-ju and Jang Sun-ha both of whom put out lots of sijo based on Christian imagination. The two poets are common in that they were born in the Japanese colonial period and started their career as a poet at an almost same time. First of all, how a sijo writer, Seon Jeong-ju applied Christian imagination to his pieces of sijo can be summarized as follows. As a poet and paster, Seon Jeong-ju wrote and published 6 volumes of sijo collection. His pieces of sijo were all written based on Christian imagination. Many of the pieces contain Christianity-related stories that were poetically represented through paradoxical imagination. Among pieces of sijo written by Seon Jeong-ju, some reveal enthusiasm for seeking after truth that he kept in mind as a clergyman and others, the poet's strong belief in the Resurrection. Next, Christian imagination that another sijo writer Jang Sun-ha reflected in his works can be briefed as follows. The poet published a sijo collection of his own in 2010. As one of the best representatives of the modern sijo circles, he is a veteran poet who is still creating pieces of sijo. Since he became a Christian in 1996, he has released more than 200 pieces of Christianity-based sijo including those contained in his sijo collection, "Introduction to Love Studies". Most of the Christian poets quoted words from the Bible or borrowed episodes described in the Book. In those poets, he uses imagination that is allusive to the confession of his faith and, in some cases implies his own views of eschatology. In conclusion, both Seon Jeong-ju and Jang Sun-ha wrote and published lots of sijo works on the basis of Christianity, and each of them built up his own world of Christian sijo. In many of the two poet's pieces of sijo, critical doctrines of Christianity and their desperate devotion to that religion are found. Both of them made remarkable poetic achievements, so they deserve being recognized as second to none in the history of Christian sijo literature.

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Effects of Tea Beverages on Cadmium Accumulation and Excretion in Rats Given Cadmium (차 음료가 카드뮴 섭취 흰쥐의 카드뮴 축적과 배설에 미치는 영향)

  • Kim, Tae-Kyung;Park, Bum-Ho;Lee, Sang-Il;Kim, Soon-Dong
    • Food Science and Preservation
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    • v.15 no.1
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    • pp.161-168
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    • 2008
  • The effects tea beverages (TBs) prepared from powdered green tea (Gt), oolong tea (Ot), black tea (Bt), or pure tea (Pt) with lemon, orange, grenadine etc on cadmium toxicity in rats were investigated Sensory evaluations of the TBs are better than those of each water extracted teas. Cadmium (50 ppm) was administered to experimental rats fed a basic diet, or a diet with various TBs (15% w/v), for 5 weeks. Although body weight gains, feed intakes, and fecal weights in all Cd-treated groups were lower than those in the normal control group (NC), feed efficiency ratio, urine volumes, liver weights, and kidney weights did not differ significantly between groups. The serum ALT and AST levels in the Cd-treated control group (Cd-Co) were higher than those in the NC animals. Serum ALT and AST levels in all Cd-treated rats fed TB-supplemented diets were lower than in animals of the Cd-Co group. Tibia and femur weights in Cd-Co animals were lower than those in NC rats. Tibia and femur weights in Cd-treated rats fed TB-supplemented diets were higher than those in Cd-Co animals. There were no between-group differences in tibia lengths; animals in the NC and TB-supplemented diet groups showed femur lengths longer than those of Cd-Co rats. Although the contents of crude ash and cadmium in the femurs of Cd-Co mts was markedly higher than in the femurs of NC animals, the cadmium content in femurs of Cd-Co rats was significantly lower than that in the femurs of NC animals. The changes in mineral levels caused by Cd administration were alleviated by every TB-supplemented diet tested Whereas fecal calcium excretion by Cd-Co animals was significantly higher than that of NC rats, calcium excretion by Cd-treated rats fed TB-supplemented diets was significantly lower than that of Cd-Co animals. Fecal cadmium excretion by all Cd-treated rats fed TB-supplemented diets was significantly higher than that of Cd-Co animals. In conclusion, this study provides experimental evidence that various TBs may regulate cadmium-induced organ toxicity by reducing cadmium accumulation in tissues through the mechanism of increasing the fecal excretion of cadmium.

Studies on Seed Germination Characteristics of Rice Cultivar ‘Danmi’ and Its Optimum Seeding Rates for Seedling Raising in Machine Transplanting (단미벼의 발아 특성 및 기계이앙 육묘시 적정 파종량)

  • Kim, Sang-Yeol;Oh, Seong-Hwan;Lee, Jong-Hee;Jeong, Kuk-Hyun;Cho, Jun-Hyeon;Lee, Ji-Yoon;Park, Sung-Tae;Song, You-Chun;Yeo, Un-Sang;Kim, Jeong-Il;Seo, Woo-Duck;Kang, Hang-Won
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.55 no.2
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    • pp.126-132
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    • 2010
  • A high sugar rice cultivar 'Danmi' which has been recently developed and released in the Functional Crop Resource Development Division, Department of Functional Crop, National Institute of Crop Science, has high glucose and sucrose contents but has a poor seed development. This defect poses some problem in ensuring stable seedling establishment in the nursery bed. We examined the germination and seedling emergence characteristics of 'Danmi' and determined an optimum seeding rate for seedling establishment. 'Danmi' seeds has a light 1,000-grain weight of 18.2g compared with Ilmibyeo's 26.7g. The 97.4% of 'Danmi' seeds has specific gravity below 1.0 while only 2.0% of seeds was fully developed with specific gravity above 1.12. However, the reverse is true in the Ilmibyeo seed used as a control cultivar. Although the seed germination of Danmi was 89-91% regardless of seed specific gravity but at a slower rate than Ilmibyeo regardless of water soaking temperatures of $20-30^{\circ}C$ because of high seed amount of specific gravity below 1.0 in 'Danmi'. It took 2~4 days longer of seed soaking in the Danmi seeds than Ilmibyeo before germination. 'Danmi' has low normal seedling emergence rate than Ilmibyeo in the seedbed soil due to high percentage of abnormal seedlings like stunting and incomplete growth. Normal seedling emergence rate of 'Danmi' in the seedbed was 62.6~64.9% for 10-day old seedling and 83.5~86.7% for 30-day old seedling which is lower by 29.6~30.0% and 11.3~12%, respectively than Ilmibyeo. Although 'Danmi' has low normal seedling emergence rate, but it has greater seed number per weight basis. Therefore, based on the normal seedling number per unit area of Ilmibyeo(control cultivar) for seedling rate of 10-day and 30-day old seedlings, the recommended seeding rate of 'Danmi' for transplanting rice is 220g seeds for 10-day old seedling and 130g for 30-day old seedling per nursery box, which is equivalent to 1.5 times seed volumes of Ilmibyeo.

Effects for the Thermal Comfort Index Improvement of Park Woodlands and Lawns in Summer (여름철 공원 수림지와 잔디밭의 온열쾌적지수 개선 효과)

  • Ryu, Nam-Hyong;Lee, Chun-Seok
    • Journal of the Korean Institute of Landscape Architecture
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    • v.42 no.6
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    • pp.21-30
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    • 2014
  • The purpose of this study was to evaluate human thermal comfort in summer by the type of greenery in parks and to explore planning solutions to supply a comfortable thermal environment in parks. The research was conducted in three different land cover types: a park with multi-wide-canopied trees(WOODLAND), park with grass(LAWN) and park with pavement(PAV) as reference sites in Hamyang-Gun SangrimPark. Field measurements of air temperature, relative humidity and wind velocity, short-wave and long-wave radiation from six directions(east, west, north, south, upward and downward) were carried out in the summer of 2014(August 21-23 and 29-30). Mean Radiant Temperature($T_{mrt}$) absorbed by a human-biometeorological reference person was estimated from integral radiation and the calculation of angular factors. The thermal comfort index PET was calculated by Rayman software, UTCI, OUT_SET$^*$ were calculated using the UTCI Calculator and the Thermal Comfort Calculator of Richard DeDear. The results showed that the WOODLAND has the maximum cooling effect during daytime, reduced air temperatures/$T_{mrt}$ by up to $5.9^{\circ}C/35^{\circ}C$ compared to PAV and lowered heat stress values despite increasing relative humidity values and decreasing wind velocity. While the LAWN had very slight cooling effects during daytime, reduced air temperatures/$T_{mrt}$ by up to $0.9^{\circ}C/3^{\circ}C$ compared to PAV, the improvement effects of the thermal comfort index was very slight. However, during nighttime the microclimatic and radiant conditions of WOODLAND, LAWN, and PAV were similar owing to the absence of solar radiation, reduction of wind velocity and an increase in relative humidity. Because the shading and evapotranspiration effects of the WOODLAND were much greater than the evapotranspiration effects of the LAWN, it can be said that the solutions for supplying comfortable thermal environment in parks are to amplify the green volumes rather than green areas. This study was undertaken to evaluate the human thermal comfort in summer of WOODLAND/LAWN parks and to determine the improvement effects of thermal comfort index. These results can contribute to the provision better thermal comfort for park users during park planning.

Properties of Hot Weather Nuclear Power Plant Concrete with Water Cooling Method and Retarding used (배합수 냉각방법 및 지연제 사용에 따른 서중 원전콘크리트의 특성)

  • Lee, Seung-Han;Jung, Yong-Wook;Jang, Seok-Soo;Yeo, In-Dong;Choi, Jong-Oh
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.14 no.9
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    • pp.4602-4609
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    • 2013
  • In summer and winter, the difference between the temperature during the day and that during the night is high, which leads to various problems during concrete placement, such as cracks and defects in the concrete as well as low durability and strength. Although nuclear power plant concrete is widely used for placement in all seasons, particular attention must be paid to its quality during the summer. Therefore, we evaluated the effects of a cooling method for mixing water, which is a commonly used hot weather precooling method, and the use of a retarder, on the characteristics of Nuclear Power Plant concrete. In the cooling method for mixing water, cold water at 5 was used, with 50% of the water content consisting of ice flakes. The effects of using a retarder were evaluated by reviewing the characteristics of the cement at the unset stage and after hardening. To evaluate the characteristics of the unset cement, we measured the slump, air volumes, setting times, and pressure strengths after hardening. Furthermore, we measured the heat of hydration at different temperatures; the loss of heat was minimized using insulation. Both the slump time and the complete ageing time of the air volume were found to be 120 min at $20^{\circ}C$ and 40 min at $40^{\circ}C$. In the case when the cooling method for mixing water was used and in the case when a retarder was used, the initial and final sets by penetration resistance were delayed, and the delay decreased with increasing air temperature. For the heat of hydration, the cooling method for mixing water not only lowered the maximum temperature but also delayed its attainment. However, the use of a retarder had no effect on the maximum temperature. Moreover, in the early ages (e.g., 3 and 7 days), the pressure strength of the concrete was lower than that of plain cement. However, the strength of 28-day concrete met the standard construction specifications.

Effectiveness Analysis for Traffic and Pedestrian Volumes of Pedestrian Pushbutton Signal (차량 및 보행자 교통량에 따른 보행자 작동신호기의 효과 분석)

  • Cho, Han-Seon;Park, Ji-Hyung;Noh, Jung-Hyun
    • International Journal of Highway Engineering
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    • v.9 no.4
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    • pp.33-43
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    • 2007
  • Because usually signal controllers on the crosswalks of mid-block provide pedestrian signals every cycle based on the fixed signal plan, pedestrian signals are provided even when there is no pedestrian demand. Consequently, signal is operated inefficiently and this may cause drivels to experience useless delay or violate the signal. Even though recently pushbuttons have been installed to improve the efficiency of pedestrian signal control in the crosswalks of mid-block and the pedestrian safety. they are not spread out national-wide in Korea because of the cost of the pushbutton equipments and the lack of an acknowledgement of the efficiency of the pushbutton. In this study, the effectiveness of the pushbutton on saving the vehicle delay was verified through before and after study in 4 study sites using a traffic micro-simulation model, VISSIM. To evaluate the viability of the pushbutton, a benefit/cost analysis was also performed for 4 study sites. It was found that B/C ratio of all of 4 study sites was greater than 1. The sensitivity analysis for the traffic volume and pedestrian volume were performed to identify the impact of the both volume on the operation of pushbutton. And, a benefit/cost analysis was performed for all scenarios. It was found that when the pedestrian volume is greater than 90ped/h, the pedestrian signal was operated same as the fixed signal plan. That is, there is no benefit of pushbutton at all once the pedestrian volume is greater than 90ped/h. When the pedestrian volume is equal to or less than 90ped/h and the traffic volume is greater than 2,500veh/h, B/C ratio is greater than 1. Also it was found that as traffic volume increases and pedestrian volume decreases, the benefit increases. In this study, the criteria for installation of pushbutton on the crosswalks of mid-block are developed through the sensitivity analysis and benefit/cost analysis. The results of this study may be used as a criteria for expansion of pushbutton system.

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Origin-Destination Estimation Based on Cellular Phone's Base Station (휴대폰 기지국 정보를 이용한 O/D 추정기법 연구)

  • Kim, Si-Gon;Yu, Byeong-Seok;Gang, Seung-Pil
    • Journal of Korean Society of Transportation
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    • v.23 no.1
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    • pp.93-102
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    • 2005
  • An Origin-Destination (O/D) is considered as one of the important information in route choices and trip assignments. A household interview survey is deemed to be the traditional and the most widely used method in making sample O/D and its conversion to the total O/D. Some researchers have studied to estimate dynamic O/D from the relationship between link volumes and trip assignment model. Nowadays, owing to the recent rapid spread of cellular phones. Location information of the cellular phone through the Base Station(BS) is considered as an alternative to O/D estimation. In this study, the methodology of generating BS-based O/D and the methodology of converting this O/D into an administrative district-based O/D are proposed. The information of GPS positions and cellular BS positions have acquired by establishing GPS equipment and cellular phone on taxies in Cheongju. Three weeks data are collected and used in estimating O/D by matching them on a digital map. Scatter diagram and sample correlation coefficients are used to investigate the similarity of the GPS-based O/D pattern among weeks, among days, and among times in day. The results show that there are few significant differences among weeks. But there is a difference in O/C pattern between weekday and weekend. Furthermore, there is a difference between morning peak and afternoon peak. Two methodologies are proposed to convert BS-based O/D into an administrative district-based O/D. The first one is to use the distribution pattern of GPS coordinates, the other is to use the coverage area of the BSs. To validate such converted O/D, GPS O/D is used as a true value. The statical analyses through scatter diagram, MAE and RMSE shows that there is few significant defference of pattern between the estimated BS-based O/D and GPS O/D. In the case of using only cellular information, the methodology using coverage area of the BSs is recommended for estimating O/D.