• 한국콘텐츠학회논문지
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• 제14권1호
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• pp.337-345
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• 2014

특수감각의 하나인 시각에 장애가 생겨 보는 것에 대한 많은 제약을 받는 시각장애인은 집안에서의 아주작은 행동에서부터 사회생활을 위한 외부 활동에 이르기까지 적지 않은 어려움을 가진다. 최근 많은 관심을 가지고 있는 건강을 지키기 위한 여러 행동들에서도 시각 부분의 장애는 많은 문제를 초래한다. 이에 수집된 자료는 연구대상자의 일반적인 특성과 구강보건행태를 빈도분석 하였으며, 구강보건 형태와 구강 건강상태를 t-test와 F-test 분석을 통해 평균비교를 하였고, 검정결과 집단 간 유의한 차이에 대해 Duncan으로 사후검정을 하였다. 일반적인 특성과 구강보건행태의 상관성을 알아보기 위해 Spearman의 상관분석을 하였으며, 주관적인 구강건강상태에 미치는 영향을 파악하기 위해 단계적 다중 회귀분석 (multiple regression analysis)을 하였다. 통계프로그램은 SPSS(SPSS20.0 for Windows, SPSS Inc, USA)를 이용하였으며, 통계적 유의성 판정을 위한 유의수준은 0.05로 고려하였다. 누구보다도 건강을 지키기 위한 행동들이 정확하게 인지되어야 하는 그룹이므로 그들의 구강에 대한 실태와 행태를 알아보고 그러한 행위에 의한 구강상태를 분석하여 시각장애인에게 알맞은 정보전달 매체 등을 만드는 것에 기초자료로 활용하고자 한다.

• PNF and Movement
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• 제14권3호
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• pp.237-244
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• 2016

Purpose: This case report examines the influence of proprioceptive neuromuscular facilitation (PNF) combined with a dynamic neuromuscular stabilization approach on balance in patients with cerebellar atrophy. Methods: The target subject of this case report was a 34-year-old woman who was informed of the purpose of this research and voluntarily agreed to participate in it. The case report conformed to research ethics based on the Helsinki Declaration. The target subject was confirmed to have cerebellar atrophy from an unknown cause in 2009 and was diagnosed with slight ataxia. At that time, she could carry out daily activities without physical therapy. On May 19, 2015, she suffered both a subdural hemorrhage (SDH) and subarachnoid hemorrhage (SAH) in a traffic accident. She was urgently moved to the emergency room and managed by nonsurgical treatment, and then, the cerebellar atrophy and ataxia gradually deteriorated. To evaluate the patient's balance capacity before and after intervention, the trunk impairment scale (TIS), trunk impairment scale (OLST) during eye-closing/opening, timed up and go test (TUG), and visual analogue scale (VAS) were conducted. The PNF intervention program was executed for 30 min, four times a week, for three weeks. Results: The TIS and OLST during eye-closing/opening were improved by as much as a point, by 8.15 s and 6.21 s, respectively, after applying the PNF program. TUG and VAS decreased by 1.33 s and 3 points, respectively, after intervention. According to the result, the OLST during eye-closing/opening and VAS improved remarkably in comparison with those before intervention. Conclusion: As the final result of the case report, PNF intervention combined with DNSA more effectively improved the static balance capacity, such as the OLST during eye-closing/opening and VAS, compared to the dynamic balance capacity. In addition, the intervention duration and period of the exercise program are recommended to be more than 1 h a day for four weeks considering the learning ability of a patient with cerebellar atrophy.

• 한국산학기술학회논문지
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• 제15권1호
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• pp.377-385
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• 2014

본 연구에서는 국제기능장애건강분류체계인 ICF 코드와 국제표준위원회 재활보조기기 분류체계인 ISO 9999의 코드 매칭을 활용한 재활 보조기기 사용자 맞춤형 정보 지원 시스템 구축에 활용할 수 있는 모바일 어플리케이션과 시각장애인을 대상으로 한 사용성 평가를 조사하였다. 장애인의 일상생활에서의 어려움을 분석하여 기능을 보다 향상시키고 어려움을 경감시킬 수 있도록 개인적 특성과 기기의 장점을 서로 매칭시켜 주는 모바일 어플리케이션은 10명의 시각장애인을 대상으로 사용성 평가를 실시한 결과 본 연구에서 개발된 ICF 코드를 활용한 모바일 어플리케이션이 온라인 의 기존 재활보조기기 신청 방식보다 효과적인 것으로 나타났다. 결과 분석은 대응표본 t-검정을 수행하였으며 신뢰수준 95%를 기본값으로 하였다. 본 연구를 통해 도출된 프로토 타입 개발에 사용된 원천 기술은 온라인 클라우드 정보 기반 서비스로 확장할 수 있으며 관련 산업 및 시장의 활성화를 촉진 시킬 수 있을 것이다.

• 대한소아치과학회지
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• 제30권3호
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• pp.510-514
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• 2003

Axenfeld-Rieger 증후군은 치과 및 안과적 이상을 동반하는 희귀한 상염색체 우성 유전성 질환이다. 주요한 안과적 증상은 부분적 혹은 완전한 양측성 홍채선조(iris stroma)의 형성 부전증, 안구 주변부의 홍채유착과 관련된 이상 및 쉬발베 소체(Schwalbe's corpuscles)의 전방 변위 등이 있다. 치과적으로는 부분적 무치증, 왜소치, 정형치(peg-shaped teeth) 및 지연맹출 등이 나타나며 안모상 가성 하악 전돌증이 보일 수 있다. 기타 전신적인 증상으로 심장 형성이상(cardiac malformation), 합지증(syndactylism), 제탈장(umbilical hernia), 귀의 이상, 정신지체, 뇌성 마비, 구개열, 제대피부이상(umbilical skin abnormality) 등이 나타날 수 있다. 소아치과 의사가 조기에 발견할 경우 환자의 절반 이상에서 나타나는 녹내장(glaucoma)에 의한 시력 상실을 조기에 방지 할 수 있다. 저자는 연세대학교 치과대학병원 소아치과에 내원한 Axenfeld-Rieger 증후군 환아에 대해 보고하는 바이다.

• Journal of Acupuncture Research
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• 제28권1호
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• pp.117-124
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• 2011

Objectives : Bell's palsy is the most common acute facial paralysis but its causes still unclear. At present, one of the most widely accepted cause is viral infections, and generally socioeconomic factors influence the viral infections. The purpose of this study is to investigate the relationship of incidence of facial palsy with socioeconomic factors. Methods : Seventeen patients with a acute facial palsy, who volunteered and completed all of the assessment measures participated. Using data on 17 participants, we examined the independent contribution of education, income, and occupation to a risk factor of severe facial palsy. Severity of global facial impairment was assessed by the facial disability index (FDI), the house-brackmann facial nerve grading system, WHO quality of life - bref (WHOQOL-BREF) and visual analogue scale (VAS) about discomfort of life. Results : There was no correlation between severity of facial palsy and gender, marriage, education, or occupation. Age greater than 60 years (p<0.05), and low monthly income(p<0.05), poor self-rated health was associated with greater severity of idiopathic facial paralysis. Conclusions : The number of subjects with facial palsy in our study (n-17) was small, and therefore generalization to larger patient populations might be unwarranted. But according to the outcome, we suggest that socioeconomic factors, especially low monthly income influence severity of bell's palsy.

• Pediatric Infection and Vaccine
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• 제23권1호
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• pp.72-76
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• 2016

골화석증은 골격의 경화증이 특징적으로 나타나는 드문 유전 질환으로 뼈 흡수 기전에 손상이 오며 조기 사망하는 질환이다. 반면 거대세포바이러스 감염은 가장 흔한 선천성 감염 중 하나로 빈혈, 혈소판 감소증과 간비장종대, 뇌 석회화 등이 나타날 수 있다. 심한 간비비대, 혈소판 감소증 및 저칼슘혈증과 발달지연으로 내원한 환자에서 두 가지 질환이 함께 있어 항바이러스제 치료 및 대증치료를 시행하였고, 치료 반응이 빠르게 나타나지는 않았으나 지속적인 치료 결과 대부분의 수치가 정상화 되는 것을 확인하였다. 본 증례는 골화석증 신생아에게 동반된 거대세포바이러스 감염의 첫 증례 보고로, 거대세포바이러스 감염에 대한 항바이러스제의 장기 치료로 호전된 사례이다.

• 한국콘텐츠학회논문지
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• 제7권4호
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• pp.199-205
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• 2007

국내에 보급되어 사용 중인 장애인용 정보통신 보조기기의 대부분은 시각장애인을 위한 기기나 소프트웨어이며, 특정 장애 유형과 특정 장애 부위에만 적용 가능한 것들이 대부분이고, 장애정도가 비교적 경도인 장애인의 특수 키보드 또는 특수 마우스 장치가 주류를 이룬다. 이 또한 전체 장애 인구에 비하면 보급률이 매우 낮은 것으로 보고되고 있다. 본 연구에서는 하나의 지능적인 특수 입력장치를 통해 다양한 장애 유형과 장애부위에 적용될 수 있는 새로운 방안을 연구하여, 이를 실제 제품화 가능한 수준으로 설계 및 구현하였다. 또한 이를 토대로 더 보편적인 보조입력 장치의 설계 및 구현 방안을 위한 제안과 향후 연구 방향에 대하여 제안하였다.

• Journal of Korean Neurosurgical Society
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• 제40권4호
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• pp.245-248
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• 2006

Objective : To evaluate the effectiveness of Novalis shaped beam radiation treatment as an adjuvant treatment in patients with craniopharyngiomas. Methods : We reviewed 8 patients with craniopharyngiomas who had recurring tumors during follow-up or had residual lesions after primary surgery. Three of 8 patients were found to have recurrence after gross total excision of the tumor and 5 patents had residual lesions after subtotal resection. All patients were treated with fractionated stereotactic radiation treatment[FSRT] using Novalis system. The mean age of patients was 28 years [range $16{\sim}52$]. The median irradiation dose per fraction was 17Gy [range $1.7{\sim}2.0$]. The median fraction number was 23 [range $15{\sim}25$], and the median total dose was 39.1 Gy [range $25.5{\sim}42.5$]. Follow-up included MR imaging, and ophthalmologic and endocrine examinations. Results : The median follow-up period was 23 months [range $12{\sim}43$]. The local tumor control rate was 87.5%. One patient had a recurring tumor, in which cystic change developed 2 months after FSRT. Four patients showed a decrease in size of their tumor, while 3 patients remained stable. Seven out of 8 patients had hormonal dysfunction that remained unchanged after initial surgery. No further progression of visual impairment was observed. Conclusion : FSRT using Novais system is effective and safe for the treatment of recurring or residual craniopharyngiomas without toxicity like optic neuropathy.

• Nutrition Research and Practice
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• 제14권3호
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• pp.203-217
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• 2020

BACKGROUND/OBJECTIVE: Centella asiatica, also known as Gotu kola, is a tropical medicinal plant native to Madagascar, Southeast Asia, and South Africa. It is well known to have biological activities, including wound healing, anti-inflammatory, antidiabetic, cytotoxic, and antioxidant effects. The purpose of this study was to determine the efficacy of extracts of C. asiatica against age-related eye degeneration and to examine their physiological activities. MATERIALS/METHODS: To determine the effects of CA-HE50 (C. asiatica 50% EtOH extract) on retinal pigment cells, we assessed the cytotoxicity of CoCl₂ and oxidized-A2E in ARPE-19 cells and observed the protective effects of CA-HE50 against N-methyl-N-nitrosourea (MNU)-induced retinal damage in C57BL/6 mice. In particular, we measured factors related to apoptosis and anti-oxidation and the protein levels of rhodopsin/opsin. We also measured glucose uptake to characterize glucose metabolism, a major factor in cell protection. RESULTS: Induction of cytotoxicity with CoCl₂ and oxidized-A2E inhibited decreases in the viability of ARPE-19 cells when CA-HE50 was administered, and promoted glucose uptake under normal conditions (P < 0.05). In addition, CA-HE50 inhibited degeneration/apoptosis of the retina in the context of MNU-induced toxicity (P < 0.05). In particular, CA-HE50 at 200 mg/kg inhibited the cleavage of pro-caspase-3 and pro-poly (ADP-ribose)-polymerase and maintained the expressions of nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 similar to normal control levels. Rhodopsin/opsin expression was maintained at a higher level than in normal controls. CONCLUSION: A series of experiments confirmed that CA-HE50 was effective for inhibiting or preventing age-related eye damage/degeneration. Based on these results, we believe it is worthwhile to develop drugs or functional foods related to age-related eye degeneration using CA-HE50.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제18권2호
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• pp.145-153
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• 2007

Objectives: This study was focused on the influence of chronic aircraft noise exposure on children's continuous performance, intelligence and reading skill. Methods: We enrolled 586 children in 4-6th grade of 7 primary schools near air base in Korea. Continuous performance was measured using the computerized ADS program. We analyzed 477-512 children on the visual continuous performance test, auditory continuous performance test, intelligence test, and reading and the vocabulary test. Intelligence was measured using vocabulary, digit span, block design, and digit symbol tests of K-WISC-III. Results: The commission error and variability deviation of auditory continuous performance test and reading test were significantly higher among children in schools with the helicopter noise and the fighting plane noise compared to children in the low noised schools. Conclusion: There was a possibility that chronic aircraft noise exposure was associated with impairment of the school performance. The result of our study also shows chronic aircraft noise was associated with reading ability.