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Post-transcriptional and post-translational regulation during mouse oocyte maturation

  • Kang, Min-Kook;Han, Seung-Jin
    • BMB Reports
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    • v.44 no.3
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    • pp.147-157
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    • 2011
  • The meiotic process from the primordial stage to zygote in female germ cells is mainly adjusted by post-transcriptional regulation of pre-existing maternal mRNA and post-translational modification of proteins. Several key proteins such as the cell cycle regulator, Cdk1/cyclin B, are post-translationally modified for precise control of meiotic progression. The second messenger (cAMP), kinases (PKA, Akt, MAPK, Aurora A, CaMK II, etc), phosphatases (Cdc25, Cdc14), and other proteins (G-protein coupled receptor, phosphodiesterase) are directly or indirectly involved in this process. Many proteins, such as CPEB, maskin, eIF4E, eIF4G, 4E-BP, and 4E-T, post-transcriptionally regulate mRNA via binding to the cap structure at the 5' end of mRNA or its 3' untranslated region (UTR) to generate a closed-loop structure. The 3' UTR of the transcript is also implicated in post-transcriptional regulation through an association with proteins such as CPEB, CPSF, GLD-2, PARN, and Dazl to modulate poly(A) tail length. RNA interfering is a new regulatory mechanism of the amount of mRNA in the mouse oocyte. This review summarizes information about post-transcriptional and post-translational regulation during mouse oocyte meiotic maturation.

Analysis of post-buckling of higher-order graphene oxide reinforced concrete plates with geometrical imperfection

  • Mirjavadi, Seyed Sajad;Forsat, Masoud;Yahya, Yahya Zakariya;Barati, Mohammad Reza;Jayasimha, Anirudh Narasimamurthy;Khan, Imran
    • Advances in concrete construction
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    • v.9 no.4
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    • pp.397-406
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    • 2020
  • The present article deals with post-buckling of geometrically imperfect concrete plates reinforced by graphene oxide powder (GOP) based on general higher order plate model. GOP distributions are considered as uniform and linear models. Utilizing a shear deformable plate model having five field components, it is feasible to verify transverse shear impacts with no inclusion of correction factor. The nonlinear governing equations have been solved via an analytical trend for deriving post-buckling load-deflection relations of the GOP-reinforced plate. Derived findings demonstrate the significance of GOP distributions, geometric imperfectness, foundation factors, material compositions and geometrical factors on post-buckling properties of reinforced concrete plates.

Post-production service of smart farming based on ICT network

  • Cho, Sokpal;Chung, Heechang
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2015.10a
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    • pp.603-606
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    • 2015
  • The post-production of smart farming defines the stage that the final products are delivered from producer to consumers via market on ICT network. It deals with the process of product packaging and distribution from producer to consumer with marketing strategy. This focus on reference model for post-production service including specialization, centralization of product delivery, and just-in-time delivery, and marketing system on the network. It defines a significant function component on post-production stage. The producer plays a significant role in economy being one of the main contributors to the many customers. This articles suggest the effective product distribution service which requires delivering the right product, in the right quantity, in the right condition, to the right place, at the right time, for the right cost, and encompassing global marketing based on ICT network, will be provided[1].

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The In Vitro Translocation of Escherichia coli Ribose-binding Protein via Various Targeting Routes

  • Lee, Byoung-Chul;Kim, Hyoung-Nan;Hwang, Yong-Il
    • BMB Reports
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    • v.34 no.2
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    • pp.118-122
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    • 2001
  • The translocation of ribose-binding protein (RBP) into the inverted membrane vesicles (IMV) of Escherichia coli and eukaryotic microsomes was studied using the in vitro translation/translocation system. It was found that RBP was translocated into heterologous eukaryotic microsomes co-translationally, as well as post-translationally However, RBP was translocated only past-translationally into IMV. Degradation fragments of RBP with the molar mass of 14 and 16 kDa were produced during the translocation into IMV However, the amount of the degradation products decreased and the mature form of RBP appeared in the presence of phenylmethylsulfonyl fluoride (PMSF). PMSF and GTP accelerated the translocation of RBF It was also found that SecB enhanced the post-translational translocation of RBP It appears that RBP is translocated via at least two targeting paths.

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Study on the Optimum Rotor Blade Design of the 5 kW HAWT by BEMT (BEMT를 이용한 5 kW급 수평축 풍력발전용 로터 블레이드 형상 최적설계에 관한 연구)

  • Kim, Mun-Oh;Lee, Min-Woo;Kim, Chang-Goo;Kim, Tae-Hyung;Lee, Young-Ho
    • 한국신재생에너지학회:학술대회논문집
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    • 2009.11a
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    • pp.444-447
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    • 2009
  • The optimum design and the performance analysis software called POSEIDON for the HAWT (Horizontal Axis Wind Turbine) was developed by use of BEMT. The Prandtl's tip loss theory was adopted to consider the blade tip loss. The aerodynamic characteristics of NACA 63415 airfoils were predicted via X-FOIL and the post stall characteristics were estimated by the Viterna's equations. All the predicted aerodynamic characteristics are fairly well agreed with the Velux wind tunnel test results. The rated power of the testing rotor is 5kW at design conditions. The power, estimated by use of predicted lift and drag coefficient via X-FOIL becomes a little higher than experimental one.

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Study on the Optimum Rotor Blade Design of the 1 kW HAWT by BEMT (BEMT를 이용한 1 kW급 수평축 풍력발전용 로터 블레이드 형상 최적설계에 관한 연구)

  • Lee, Min-Woo;Kim, Jeong-Hwan;Kim, Jung-Ryul
    • Journal of Advanced Marine Engineering and Technology
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    • v.31 no.4
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    • pp.356-362
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    • 2007
  • The optimum design and the performance analysis software called POSEIDON for the HAWT (Horizontal Axis Wind Turbine) was developed by use of BEMT. The Prandtl's tip loss theory was adopted to consider the blade tip loss. The aerodynamic characteristics of NACA 63-415 airfoils were predicted via X-FOIL and the post stall characteristics were estimated by the Viterna's equations. All the predicted aerodynamic characteristics are fairly well agreed with the Velux wind tunnel test results. The rated power of the testing rotor is 1 kW at design conditions. The power, estimated by use of predicted lift and drag coefficient via X-FOIL becomes a little higher than experimental one.

The Sogdian Descendants in Mongol and post-Mongol Central Asia: The Tajiks and Sarts

  • LEE, JOO-YUP
    • Acta Via Serica
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    • v.5 no.1
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    • pp.187-198
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    • 2020
  • This paper is devoted to the examination of the identity of the Sogdian descendants and their historical role in the second millennium CE. More specifically, it discusses the Sogdian connection to the later Iranic-speaking peoples of Central Asia, namely, the Sarts and the Tajiks. It then discusses the symbiotic relationship between the Sogdian descendants and the Mongols and the Mongol descendants (Chaghatays and Uzbeks) in Central Asia. In sum, this paper argues that the Sogdians did not perish after the Arab conquest of Central Asia in the eighth century CE. They survived under new exonyms Sart and Tajik. Like the Sogdians in pre-Islamic Central Asia, the Tajiks or Sarts played important historical roles in the Mongol and post-Mongol states of Central Asia, maintaining a symbiotic relationship with the nomad elites.

Arrival at the Caspian Coast: Migration, Informality and Urban Transformation in Sumqayit, Azerbaijan

  • JAGER, PHILIPP FRANK
    • Acta Via Serica
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    • v.5 no.2
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    • pp.51-90
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    • 2020
  • The city of Sumqayit in Azerbaijan was famous in the USSR for its chemical plants, which supplied the whole country with plastics, detergents, and fertilizers. While production increased in the post-WWII period, young people from remote Caucasian villages were attracted as workers to the industrial settlement on the shore of the Caspian Sea and worked together with specialists from all over the USSR. Migration did not stop when the USSR collapsed. To the contrary, mobility increased as Azerbaijani refugees from Armenia and IDPs from Karabakh fled to Sumqayit, which grew to become the second-largest city of Azerbaijan. Although a generation has passed since the ceasefire, IDPs still are separately administered. In the last 20 years, more and more internal migrants have chosen the Greater Baku Region as their destination, mostly finding jobs in the informal labor market. In the post-independence transformative period, informal housing has offered migrants a place to stay in the city. Sumqayit can be regarded as an arrival city, an established urban platform for migrants who prefer internal over transnational migration.

A Hybrid Intervention for Post-infarction Papillary Muscle Rupture with Severe Mitral Regurgitation: A Case Report

  • Nakamae, Kosuke;Oshitomi, Takashi;Uesugi, Hideyuki
    • Journal of Chest Surgery
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    • v.55 no.3
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    • pp.239-242
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    • 2022
  • Papillary muscle rupture with severe acute mitral regurgitation is a rare complication of acute myocardial infarction (AMI) that causes pulmonary congestion and cardiogenic shock. Moreover, it has a poor prognosis. Surgical intervention, including revascularization, is indicated; however, surgical mortality remains high. We report the case of an 85-year-old woman with cardiogenic shock from severe acute mitral regurgitation, in whom a hybrid intervention, combining percutaneous coronary intervention with mitral valve replacement via minithoracotomy, was performed after post-infarction papillary muscle rupture. She was discharged in a favorable clinical condition. We describe a novel hybrid intervention for treating a rare complication of AMI, which could minimize surgical invasion in elderly patients, prevent disuse syndrome after the intervention, and improve prognosis. However, mitral valve surgery via minithoracotomy for emergency cases requires technical proficiency, as well as collaboration with other healthcare professionals, and the choice to perform this procedure requires careful consideration.

STATISTICAL MODELLING USING DATA MINING TOOLS IN MERGERS AND ACQUISITION WITH REGARDS TO MANUFACTURE & SERVICE SECTOR

  • KALAIVANI, S.;SIVAKUMAR, K.;VIJAYARANGAM, J.
    • Journal of applied mathematics & informatics
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    • v.40 no.3_4
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    • pp.563-575
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    • 2022
  • Many organizations seek statistical modelling facilitated by data analytics technologies for determining the prediction models associated with M&A (Merger and Acquisition). By combining these data analytics tool alongside with data collection approaches aids organizations towards M&A decision making, followed by achieving profitable insights as well. It promotes for better visibility, overall improvements and effective negotiation strategies for post-M&A integration. This paper explores on the impact of pre and post integration of M&A in a standard organizational setting via devising a suitable statistical model via employing techniques such as Naïve Bayes, K-nearest neighbour (KNN), and Decision Tree & Support Vector Machine (SVM).