• Title/Summary/Keyword: vasodilating action

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A Study on the Analgesic, Sedative and Antihypertensive activities of ‘Inchungback’ (인중백(人中白)의 진통(鎭痛).진정(鎭靜) 및 혈압강하작용(血壓降下作用)에 관한 연구(硏究))

  • Rho, Young-Soo;Hong, Nam-Doo;Cho, Young-Whan
    • Korean Journal of Pharmacognosy
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    • v.16 no.2
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    • pp.65-72
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    • 1985
  • These studies were conducted to investigate the effect of 'Inchungbaek' water extract on analgesic and sedative actions, the relaxing action of isolated ileums, vasodilating action and blood pressure. The results of these studies were summarized as follows: Analgesic and sedative actions of 'Inchungbaek' were recognized in mice and rats. The relaxing action of isolated ileums were seen in mice and rabbits, antagonist action was seen acetylcholine and $BaCl_2-induced$ contraction of isolated ileums, and then recognized direct action in the ileum smooth muscle. Hypotensive and vasodilating actions due to vascular smooth muscle relaxation were noted in rabbits and cats.

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Studies on the Efficacy of Combined Preparation of Crude Drug (XLI) -Effects of Tongkwan-San- (생약복합제제(生藥複合製劑)의 약효연구(藥效硏究)(제41보(第41報)) -통관산(通關散)의 효능(效能)에 대하여-)

  • Chae, Byung-Yun;Hong, Nam-Doo;Kim, Nam-Jae;Kim, Jin-Sik
    • Korean Journal of Pharmacognosy
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    • v.21 no.2
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    • pp.163-172
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    • 1990
  • These studies were conducted to investigate the effects of Tongkwan-San water extract on analgesic, sedatative, anti-inflammatory, blood pressure and vasodilating actions, the relaxing action of isolated ileums and actions on the contact dermatitis induced by picryl chloride and on the leakage of the dye into the peritoneal cavity. The results of these studies were summarized as follows: The analgesic effect of Tongkwan-San was noted. The prolongation of anesthetic time of Tongkwan-San was recognized. Spontaneous motilities of isolated ileum of mice were strongly suppressed by Tongkwan-San. It inhibited the contractions of isolated ileum of mice induced by acetylcholine and barium chloride and the contraction of isolated ileum of guinea-pig induced by histamine. Inhibition of the contact dermatitis induced by picryl chloride was recognized. Anti-inflammatory effects in the paw edema induced by histamine and dextran were significantly shown. The leakage of dye into the peritoneal cavity in mice was significantly inhibited. Hypotensive and vasodilating action due to vascular smooth muscle relaxation were noted in rats and rabbits.

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EFFECT OF A NEW POSITIVE INOTROPIC AGENT, YS-49, A NOVEL TETRAHYDROISOQUINOLINE COMPOUND

  • Lee, Y. S.;Park, H. S. Yoon-;K. C. Chang
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1995.04a
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    • pp.88-88
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    • 1995
  • Tetrahydroisoquinoline (THI) compounds have various pharmacological actions in the cardiovascular system. Recently, we have synthesized 1-${\alpha}$-naphthylmethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, YS 49. In the present study, we evaluated the effect of YS-49 on positive inotropic and chronotropic action using isolated rat heart and on blood pressure and heart rate using anesthesized rabbit. Vasodilating action was also assessed in isolated rat thoracic aorta. YS 49, concentration-dependently relaxed rat aorta precontracted with phenylephrine (PE, 0.3 ${\mu}$M) and high potassium (high K$\^$+/, 65.4 mM). The 50% inhibitory concentration (IC$\sub$50/) of YS 49 in PE-induced and high K$\^$+/-induded contraction was 5.36 ${\mu}$M and 2.52 ${\mu}$M, respectively. In isolated rat atria, YS 49 increased both heart rate and force, and in anesthesized rabbit it decreased blood pressure but increased heart rate. In addition, to know the mechanism of action of the compound, propranolol, nonselective ${\beta}$-antagonist, and phentolamine, ${\alpha}$-blocker, were used. Furthermore, a comparison with the effect of higenamine, trimetoquinol on the vasodilating action in rat thoracic aorta was also made. The action of YS 49 was inhibited by the presence of propranolo, not pentolamine. These results indicate that cardiotonic and vasodilatory action of YS 49 is attributable, at least in part, for ${\beta}$-receptor stimulation.

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Further Investigation of the Action Mechanism of GS 389: a Thromboxane $A_2$ Antagonistic Action

  • Noh, Hong-Ki;Chang, Ki-Churl
    • Biomolecules & Therapeutics
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    • v.3 no.2
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    • pp.143-148
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    • 1995
  • Recently, we reported that GS 389 has vasodilating action without cardiac inotropic action (Chang et al., Can. J. Physiol. Pharmacol. 72, 327-334, 1994). However the mechanism of action of GS 389 has not been thoroughly evaluated. In the present study, we performed functional study of GS 389 in rat trachealis, thoracic aorta, pig coronary artery by isometric tension and in human platelets by aggregation experiments. We also tested if GS 389 influences on $Ca^{2+}$movement and inositol phosphate metabolism. In rat trachealis, GS 389 concentration-dependently relaxed carbachol (0.1 $\mu$M)- and high $K^{+}$(65.4 mM)-induced contraction with p$IC_{50}$/ of 4.43$\pm$ 0.19 and 4.11$\pm$0.12, respectively. In $Ca^{2+}$-free media, GS 389 inhibited carbachol-induced phasic contraction. In rat thoracic aorta, GS 389 inhibited $^{45}$ Ca uptake due to norepinephrine and high $K^{+}$, indicating that GS 389 has direct inhibitory action of $Ca^{2+}$movement. Furthermore, GS 389 competitively inhibited U46619-induced contraction in rat thoracic aorta and pig coronary artery with K, values of 5.23$\pm$0.12 and 5.56$\pm$0.14, respectively, and inhibited U 46619-induced phosphatidylinositide (PI) turnover in rat aorta. GS 389 also concentration-dependently inhibited the human platelet aggregation against U 46619 with p$IC_{50}$/ 5.66$\pm$0.02. These results indicate that GS 389 has thromboxane $A_2$ antagonistic action in vascular and platelets as well as direct action on $Ca^{2+}$ movement, which may account, at least in part, for relaxing action of rat trachealis. trachealis.

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Studies on the Efficacy of Combined Preparation of Crude Drugs(XXXI) -The Effect of Taeksa-tang on Diuresis, Serum Lipid, Isolated Ileum, Heart, Blood Vessel, Blood Pressure and Respiration- (생약(生藥) 복합제제(複合製劑)의 약효(藥效) 연구(硏究)(제31보)(第31報) -택사탕(澤瀉湯)이 이뇨(利尿), 고지혈증(高脂血症), 적출장관(摘出腸管), 적출심장(摘出心臟), 혈관(血管), 혈압(血壓) 및 호흡(呼吸)에 미치는 영향(影響)-)

  • Nam, Sang-Kyung;Lee, Dong-Suk;Kim, Nam-Jae;Lee, Kyung-Sup;Hong, Nam-Doo
    • Korean Journal of Pharmacognosy
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    • v.17 no.4
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    • pp.263-271
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    • 1986
  • In order to investigate experimentally the clinical effects of Taeksa-Tang that was prescribed to cure the severe dizziness, the water extract of Taeksa-Tang was experimented about the effects on the diuretic action, the serum lipid, the isolated ileum and heart, the blood vessel, the blood pressure and respiration. The results of this study were obtained as follows: The diuretic action was significantly shown in rabbits. The level of total cholesterol, triglyceride and phopholipid in serum of rabbits given high cholesterol diet were significantly decreased. The contraction of the isolated ileum of mice induced by acetylcholine chloride and barium chloride was remarkably inhibited. The vasodilating and hypotensive actions were noted in rabbits. Negative inotropic action on the isolated frog heart was recognized.

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Effect of Nifedipine on Renal Function in Dogs (Nifedipine의 개 신장기능에 미치는 영향)

  • 고석태;은중영
    • YAKHAK HOEJI
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    • v.31 no.6
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    • pp.376-393
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    • 1987
  • This study was performed in order to investigate the effect of nifedipine, a vasodilating drug which acts through calcium antagonism, on renal function using mongrel dog. Nifedipine, when given interavenously in doses ranging from 1.5 to 5.0$\mu\textrm{g}$/kg, elicited diuresis along with less changes of glomerular filtration rate and significant increases of renal plasma flow, so that the filtration fraction(FF) decreased significantly, at the same time both osmolar and free water clearances increased, and amount of sodium, potassium and calcium excreted in urine increased significantly. Nifedipine, when infused into a renal artery in doses from 0.05 to 0.15$\mu\textrm{g}$/kg/min, exhibited identical responses to the actions of intraveneous nifedipine except significant increase of glomerular filtration rate and no change of FF, which was confined only to the infused kidney. The renal action of nifedipine into a renal artery were not influenced by renal denervation, decreased significantly by ouabain, Na$^+$-K$^+$-ATPase inhibitor, which was given into a renal artery. Nifedipine infused into a renal artery in dog pretreated with propranolol i.v. produced diuresis associated with the increase of electrolytes excretion by reduction of electrolyte reabsorption and with no changes of glomerular filtration rate and renal plasma flow. Thus, it is concluded that nifedipine infused into a renal aretery produces diuretic action along with both improvement of hemodynamics and inhibition of electrolytes reabsorption, which may be related to sympathetic $\beta$-receptor or Na$^+$-K$^+$-ATPase activity because the action of nifedipine in kidney is blocked by propranolol or ouabain.

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Studies on the Efficacy of Combined Preparation of Crude Drug (XIX) -The effect of ‘Samulanshintang’ on the Cardiovascular System and Anemic Rabbits induced by Phenylhydrazine- (생약복합제제(生藥複合製劑)의 약효(藥效) 연구(硏究) (제19보)(第19報) -사물안신탕(四物安神湯)이 순환기계(循環器系) 및 Phenylhydrazine으로 유발(誘發)된 가토빈혈(家兎貧血)에 대한 영향(影響)-)

  • Hong, Nam-Doo;Lee, Kyung-Sup;Whang, Wei-Wan;Kim, Nam-Jae
    • Korean Journal of Pharmacognosy
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    • v.15 no.4
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    • pp.188-193
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    • 1984
  • It was previously indicated that 'Samulanshintang' had been examined for effects of the anticonvulsive, antipyretic, analgesic, sedative and antispasmodic actions. In order to investigate the effect on the cardiovascular system and anemic rabbits induced by phenlhydrazine HCl, pharmacological studies have been carried out with extract. The results of this investigation were summarized as follows: The relaxation of bronchial smooth muscle and antihistamine action were recognized. Antihypertensive and vasodilating actions due to vascular smooth muscle relaxation were noted in frogs and rabbits. 'Samulanshintang' lowered the rate of anemia induced by phenylhydrazine and rapidly recovered from the anemia state.

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Studies on the Efficacy of Combined Preparation of Crude Drugs (XXVII) -Experimental studies on the efficacy of Chunghyulgangki-Tang- (생약(生藥) 복합(複合) 제제(製劑)의 약효(藥效) 연구(硏究)제27보(第27報) -청혈강기탕(淸血降氣湯)의 약효(藥效)에 관한 실험적(實驗的) 연구(硏究)-)

  • Song, Il-Byung;Hong, Nam-Doo;Kim, Nam-Jae;Ko, Byoung-Hee
    • Korean Journal of Pharmacognosy
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    • v.17 no.2
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    • pp.113-122
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    • 1986
  • In order to investigate the pharmacological activities of the combined preparation of crude drugs, Chunghyulgangki-Tang was studied. Chunghyulgangki-Tang has been widely used to cerebral apoploxy, hypertension and arteriosclerosis, etc. In this study, water extract of Chunghyulgangki-Tang was conducted in attempt to investigate for analgesic, sedative, antipyretic, isolated ileum and heart, blood vessels and blood pressure action in mice, frogs, rats, guinea-pigs and rabbits. The following results were obtained; Analgesic action by the acetic acid stimulating method in mice was recognized. Sedative activities by the wheel cage method and rotor rod method in mice were shown. Prolonged action against the hypnotic duration induced by thiopental-Na was significantly noted in mice. The effect of antipyretic in endotoxin febrile rats was significantly recognized. Spontaneous motility of the isolated ilem of mice was suppressed and contractions of the isolated ileum of mice and guinea-pigs induced by acetylcholine chloride, barium chloride and histamine were remarkably inhibited. Acceleration of isolated heart motility was shown in frogs. Vaso-dilating and hypotensive actions were recognized in rabbits. According to the above results, effects based on the oriental medicinal references were approximate to the actural experimental results.

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Effect of Flunarizine on Experimental Ischemia and Hypoxia in Rats and Mice (실험적(實驗的) 뇌허혈(腦虛血) 및 저산소증(低酸素症)에 대한 Flunarizine의 약효(藥效) -뇌장해에 대한 Flunarizine 효능-)

  • Kim, Eun-Mi;Kim, Young-Jin;Shin, Jeoung-Hee;Yun, Jae-Soon
    • YAKHAK HOEJI
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    • v.32 no.5
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    • pp.343-350
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    • 1988
  • Recent hypothesis suggested that intracellular accumulation of calcium is a common denominator of ischemic celullar damage. Flunarizine, a calcium entry blocker, posses vasodilating properties in cerebral vascular beds and clinically used in circulatory disorders. The present study was designed to evaluate the effect of flunarizine on ischemic and hypoxic brain damage. An ischemic model was made by bilateral carotid artery ligation (BCAL) in Wistar strain rat. Hypoxic model was made by intravenous injection(i.v.) of KCN to rats and mice. In mice, flunarizine not only reduced the mortality of KCN, but also delayed the onset time of convulsion. The contents of ATP, creatine phosphate and glucose, cerebral energy metabolite, decreased 30 minutes after BCAL and KCN i, v, while that of lactate increased. But these variations were suppressed by flunarizine. Furthermore, increase in the dosage of flunarizne generally promoted the recovery of cerebral energy metabolites in hypoxic animals. The results suggest that flunarizine had a protective effect against ischemic and hypoxic brain damage due to its ameliorating action on the cerebral energy metabolism.

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Mechanisms Underlying the Inhibitory Effect of GS 283 in Various Smooth Muscles (GS 283의 평활근 억제 작용기전)

  • Kim, Si-Hwan;Lee, Young-Soo;Chong, Won-Seog;Chang, Ki-Churl
    • The Korean Journal of Pharmacology
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    • v.30 no.1
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    • pp.101-109
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    • 1994
  • Pharmacological characterization of GS 283, a tetrahydroisoquinoline derivative has been elucidated using rat thoracic aorta, guinea pig tenea coli and rabbit mesentery artery in vitro. GS 283 showed calcium antagonistic action in vascular smooth muscle, since high $K^+-induced$ contraction was concentration dependently inhibited. GS 283 also inhibited the contraction induced by ${\alpha}_1$ receptor activation. Vasodilating action of GS 283 was not modified by the propranolol, indicating that GS 283 has no ${\beta}$ receptor stimulatory action. Simultaneous measurement of intracellular calcium change and muscle tension indicated that the inhibitory effect of GS 283 was accompanied by the increase in tissue fluorescence. This increment was not due to fura 2 fluorescence but to endogenous pyridine nucleotide, suggesting that GS 283 has an effect to inhibit mitochondrial function. GS 283 had an inhibitory action on cyclic AMP and GMP-dependent phosphodiesterases from rat brain with Ki values of 2.5 and 6.7 mM. From these findings we concluded that GS 283 has multiple action such as the inhibition of cyclic nucleotide-dependent phosphodiesterases, blocking of calcium channel as well as inhibition of mitochondrial function which are responsible for vasodilatation.

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