• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3419-3423
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• 2013

Of all gynecologic cancers, endometrial cancer is the most common cancer in the US and Europe. In addition, it is presently the second most common gynecologic cancer in the world. As a result of increasing menopausal, obese and tamoxifen use women, the incidence of the cancer seems to be on the increase. Surgery is the major treatment, whereas postoperative radiation therapy in high-intermediate risk patients many prevent locoregional recurrence. Adjuvant chemotherapy can improve progression free survival in advanced or recurrent cancers. Molecular targeted therapies are now a focus of attention including anti-vascular endothelial growth factor (VEGF), mammalian target of rapamycin (mTOR) inhibitor and tyrosine kinase inhibitor (TKI). They may provide useful future strategies for control of endometrial malignancies in developing countries and across the world.

• Molecular & Cellular Toxicology
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• 제3권4호
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• pp.238-245
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• 2007

Chronic formaldehyde inhalation studies have suggested its relativity to teratogenicity, cancer incidence, neurodegenerative and vascular disorders. Many toxicological data on the formaldehyde toxicity are available, but proteomic results showing complete protein profiles are limited. Therefore, alterations of protein expression patterns upon formaldehyde treatment were investigated in the human lung epithelial cell line. Differentially expressed proteins following formaldehyde treatment were analyzed on 2-dimensional gels, and further analyzed by MALDI-TOF to identify the proteins. Among the identified proteins, 24 proteins were notably up-regulated and 6 proteins were down-regulated. In particular, cytoskeleton related protein named vinculin and Rho GDP dissociation inhibitor which plays a key role in apoptosis increased remarkably.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제19권4호
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• pp.276-280
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• 2016

Dieulafoy lesions, vascular anomalies typically found along the gastrointestinal tract, have been viewed as rare and obscure causes of sudden intestinal bleeding, especially in pediatric patients. Since their discovery in the late 19th century, the reported incidence has increased. This is due to an increased awareness of, and knowledge about, their presentation and to advanced endoscopic diagnosis and therapy. Our patient was a three-year-old male, without a complex medical history. He presented to the emergency department with acute hematemesis with blood clots and acute anemia requiring blood transfusion. Endoscopy revealed four isolated Dieulafoy lesions along the lesser curvature of the stomach, which were treated with an epinephrine injection. The Dieulafoy lesion, although thought to be rare, should be considered when investigating an acute gastrointestinal bleed. These lesions have been successfully treated endoscopically. Appropriate anticipation and preparation for diagnosis and therapy can lead to optimal outcomes for the pediatric patient.

• 한국식품위생안전성학회:학술대회논문집
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• 한국식품위생안전성학회 1992년도 학술강연회
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• pp.1-5
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• 1992

There is increasing awareness of the devastating socio-economic cost of cardiovascular disease. As a result there have been a lot of extensive researches both on basic mechanisms involved and on the areas of epidemiology and clinical trials. Now, it is being generally accepted that dietary n-3 fatty acids abundant in marine products, may reduce the incidence of cardiovascular disease. Fish oil, with its complement of n-3 fatty acids, has been shown to have diverse and sometimes potent actions on cells of the blood and vasculature, which may explain some of its positive effects on vascular disease. However, the appropriate intake of n-3 fatty acids has not been established. This may vary with desired effects, the duration of ingestion, the type of seafood or fish oil and amount of other fatty acids, especially nf fatty acid being consumed in the diet, Although the beneficial effects have been extensively studied, little is known about potential adverse effects with excessive intake of n-3 fatty acids. Thus, it is needed to study on the possible unfavorable effects including genetic effects.

• 한국식품위생안전성학회지
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• 제7권2호
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• pp.101-105
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• 1992

There is increasing awareness of the devastating socio-economic cost of cardiovascular disease. As a result there have been a lot of extensive researches both on basic mechanisms involved and on the areas of epidemiology and clinical trials. Now it is being generally accepted that dietary n-3 fatty acids abundant in marine products, may reduce the incidence of cadiovascular disease. Fish oil . with its complement of n-3 fatty acids, has been shown the have diverse and sometimes potent actions on cells of the blood and vasculature, which may explain some of its positive effects on vascular disease. However, the appropriate intake of n-3 fatty acids has not been established. This may vary with desired effects, the duration of ingestion, the type of seafood or fish oil and amount of other fatty acids, especially n-6 fatty acid being consumed in the diet. Although the beneficial effects have been extensively studied, little is known about potential adverse effects with excessive intake of n-3 fatty acids. Thus, it is needed to study on the possible unfavorable effects including genetic effects.

• Journal of Chest Surgery
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• 제23권6호
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• pp.1238-1243
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• 1990

Bacterial endocarditis has been well recognized as an important complication of congenital heart disease. The most common. form of congenital heart disease is the VSD, of which natural history is spontaneous closure, pulmonary vascular disease, symptoms, and endocarditis. The incidence of endocarditis is relatively low. But endocarditis is almost universally fatal if untreated. Two cases of VSD with endocarditis, 4 \ulcorneryear male and 17 \ulcorneryear female, were treated at Department of Thoracic and Cardiovascular Surgery, Chonbuk National University. In the First case, the VSD was perimembranous type and vegetation located on the septal leaflet of the tricuspid valve. After 7 week medical treatment, simple closure of the VSD, removal of vegetation, and tricuspid annuloplasty were performed. In the second case. the VSD was subpulmonic type and the pulmonic valve was destructed due to vegetation. So the VSD was closed with interrupted 4 \ulcorner0 Prolene sutures and the pulmonic valve was excised. Postoperative course of all cases was uneventful.

• Journal of Korean Neurosurgical Society
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• 제66권3호
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• pp.298-307
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• 2023

Remarkable advances in neonatal care have significantly improved the survival of extremely low birth weight infants in recent years. However, intraventricular hemorrhage (IVH) continues to be a major complication in preterm infants, leading to a high incidence of cerebral palsy and cognitive impairment. IVH is primarily caused by disruption of the fragile vascular network of the subependymal germinal matrix, and subsequent ventricular dilatation adversely affects the developing infant brain. Based on recent research, periventricular white matter injury is caused not only by ischemia and morphological distortion due to ventricular dilatation but also by free iron and inflammatory cytokines derived from hematoma and its lysates. The current guidelines for the treatment of posthemorrhagic hydrocephalus (PHH) in preterm infants do not provide strong recommendations, but initiating treatment intervention based on ultrasound measurement values before the appearance of clinical symptoms of PHH has been proposed. Moreover, in the past decade, therapeutic interventions that actively remove hematomas and lysates have been introduced. The era is moving beyond cerebrospinal fluid shunt toward therapeutic goals aimed at improving neurodevelopmental outcomes.

• 한국균학회지
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• 제25권1호통권80호
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• pp.10-19
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• 1997

무우품종(Raphanus sativus L.) Saxa Nova에 시들음병을 일으키는 Fusarium oxysporum f. sp. raphani (FOR)에 대해 저항성을 증가시켜 방제효과를 얻기 위하여 식물성장을 증진시키는 것으로 알려진 Pseudomonas florescens WCS374 (WCS 374), P. putida RE10 (RE10) 및 Pseudomonas sp. EN41S (EN415)을 병원균처리 토양에 단독 또는 혼합처리하여 4주간 폿트배양한 후 무우에 나타나는 외부 및 내부병징을 조사하여 처리세균에 의한 병억제 효과를 측정하였다. 내부 및 외부병징으로 대조구는 각각 46.5% 및 21.1%를 나타내었고, RE10처리는 내외병징이 각각 12.2%와 7.8%로 발병이 억제됨을 알 수 있었다. 그러나 발병억제력이 높다고 알려진 WCS374는 내외 병징이 각각 45.6%와 27.8%로 나타났다. 한편 RE10균주를 WCS374 또는 EN415 균주와 혼합하여 처리할 경우 내외 병징이 10.0-22.1% 정도이었고 EN415와 혼합처리하면 7.8-20.2%의 병징을 나타낸다. FOR의 뿌리점유율은 뿌리에서 $2.4-5.1{\times}10^3/g$였고 토양내 분포수는 $0.7-1.3{\times}10^3/g$이었다. 대조구는 뿌리에서 $3.8{\times}10^3/g$였으며 RE10의 처리는 $2.9{\times}10^3/g$로 분포수가 적었고, 3종 세균의 혼합처리는 $5.1{\times}10^3/g$으로 많이 관찰되었으나, 처리간에 통계적 차이는 없었다. 토양에서 관찰된 FOR은 부리부분 보다 그 분포 수가 적었다. 처리된 3가지 세균은 뿌리에서 $2.3-4.0{\times}10^7/g$ 범위이고, 토양에서는 $0.9-1.8{\times}10^7/g$으로 뿌리에서 관찰된 수 보다 적게 분포하였다. 뿌리부분에서 대조구나 RE10의 처리토양은 형광성 Pseudomonas spp.의 분포수가 적고 처리간에는 통계적 차이를 나타냈으나, 토양조사에서 이세균은 큰 차이를 나타내지 않았다. 뿌리에 처리된 세균과 FOR의 분포수는 토양에 처리된 것과 대조하였을 때 많았으며, 이 실험 에 사용된 RE10과 EN415은 Fusarium시들음병에 대한 기주의 저항성을 유도하는 것으로 생각된다.

• 보건행정학회지
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• 제29권3호
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• pp.303-311
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• 2019

Background: Cerebrovascular disease is included in four major diseases and is a disease that has high rates of prevalence and mortality around the world. Moreover, it is a disease that requires a high cost for long-term hospitalization and treatment. This study aims to figure out the correlation between grip strength, which was presented as a simple, cost-effective, and relevant predictor of cerebrovascular disease, and cerebrovascular disease based on the results of a prior study. And furthermore, our study compared model suitability of the model to measuring grip strength and relative grip strength as a predictor of cerebrovascular disease to improve the quality of cerebrovascular disease's predictor. Methods: This study conducted an analysis based on the generalized linear mixed model using the data from the Korea Longitudinal Study of Ageing from 2006 to 2016. The research subjects consisted of 9,132 middle old age people aged 45 years or older at baseline with no missing information of education level, gender, marital status, residential region, type of national health insurance, self-related health, smoking status, alcohol use, and economic activity. The grip strength was calculated the average which measured 4 times (both hands twice), and the relative grip force was divided by the body mass index as a variable considering the anthropometric figure that affects the cerebrovascular disease and the grip strength. Cerebrovascular diseases, a dependent variable, were investigated based on experiences diagnosed by doctors. Results: An analysis of the association between grip strength and found that about 0.972 (odds ratio [OR], 0.972; 95% confidence interval [CI], 0.963-0.981) was the incidence of cerebral vascular disease as grip strength increased by one unit increase and the association between relative grip strength and cerebrovascular disease found that about 0.418 (OR, 0.418; 95% CI, 0.342-0.511) was the incidence of cerebral vascular disease as relative grip strength increased by unit. In addition, the model suitability of the model for each grip strength and relative grip strength was 11,193 and 11,156, which means relative grip strength is the better application to the predictor of cerebrovascular diseases, irrespective of other variables. Conclusion: The results of this study need to be carefully examined and validated in applying relative grip strength to improve the quality of predictors of cerebrovascular diseases affecting high mortality and prevalence.

• 농촌의학ㆍ지역보건
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• 제33권3호
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• pp.303-315
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• 2008

- Abstract - Objectives: The purpose of this study was to estimate the prevalence of depression and identify its related factors among an urban elderly. Methods: The data for this study were obtained from 333 men and 514 women, aged 65-79 years who participated in '2007 community health survey' in Donggu, Gwangju metropolitan city. Their depressive symptoms were measured by Korean version of the Center for Epidemiological Studies-Depression Scale (CES-D). Results: The mean CES-D score (mean±S.D) for all subjects was 7.68±0.31. The mean CES-D score was significantly greater in the women (9.09±0.43) than in the men (5.51±0.39) (p<0.001). The prevalence rates of possible depression (CES-D score ≥16), probable depression (CES-D score≥21), and definite depression (CES-D score≥25) were 8.1%, 5.4%, and 3.9% in men, respectively. The prevalence rates of possible depression, probable depression, and definite depression were 19.5%, 11.1%, and 7.2% in women, respectively. Existence of spouse (no/yes), education level (no/high school or higher), health security system (medical aid/national health insurance), self-reported health status (poor/good), vascular risk factors (present/absent) proved to be statistically significant related factors of depression. Conclusions: This study suggests that a systematic effort and attention to support for elderly people living alone, low educational level, medical aid, poor self-reported health status and vascular risk factors should be promoted to reduce the incidence of depression.