• 디지털융복합연구
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• 제12권10호
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• pp.587-595
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• 2014

본 연구의 목적은 비만흡연자의 복합운동이 당뇨발생예측률 및 신체조성, 혈관탄성에 미치는 영향을 분석하여 비만흡연자의 건강한 삶을 위한 효과적인 운동프로그램을 제시하는데 있다. 본 연구의 취지를 충분히 설명하고 자발적 참여의 동의서를 작성한 D광역시에 소재한 H기업체의 협력업체 T기업에 근무하는 40대 비만흡연 사원 20명이었으며, 과거병력과 현재 특별한 질환이 없고 규칙적인 운동경험이 없는 자들로 구성하였다. 이들은 당뇨발생률예측률 및 신체조성, 혈관탄성 검사를 실시하였으며, 실험 전과 12주간 복합운동 실시 후 평균과 표준편차를 산출하기 위하여 기술통계를 실시하였고 실험 전 후 차이 검증은 Paired t-test를 이용하여 분석하였다. 통계적 유의수준은 p<.05로 설정하여 다음과 같은 결론을 얻었다. 12주간 복합운동프로그램 참여 후 당뇨발생예측률, 체중, 체지방률, 골격근량, 복부지방률 및 혈관탄성 상지(오른손, 왼손), 하지(오른발, 왼발)에서 통계적으로 유의한 수준의 변화를 보였다(p.<05).

• 한국정밀공학회지
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• 제28권4호
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• pp.526-533
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• 2011

This research is about the pulsatile pump system utilized in the perfusion bioreactor for the in vitro human tissue culture. A pulsatile pump system which can be applied to the culture of the vascular tissues including blood vessel is developed by using the idea of human heart's blood pumping into organs as followings: culture chamber, a pressurizing device which generates laminar pulsatile flow by controlling the x-sectional area of the culture media delivering tubing, a compliance chamber which supplies the pressuring device with a constant pressure, and a peristaltic pump which circulates the culture media in a circuit ranging from the culture chamber to the compliance chamber. The developed pulsatile pump system shows that a physiology of the human heart's blood pumping including pulsatile pressure waveform of systolic-diastolic pressure is well represented. Not only time domain but also frequency domain characteristics of pulsatile pump system which are necessary for the vascular tissue culture such as pulsatile pressure waveform's shape, the frequency, and the magnitude can be easily generated and manipulated by using the proposed system.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2011년도 제43차 동계학술발표논문집 19권1호
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• pp.111-112
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• 2011

본 연구에서는 광전 용적맥파(photoelectric plethysmography, PPG)를 기반으로 이를 이용하여 혈관 탄성도를 측정 할 수 있는 시스템에 관하여 연구하였다. 광전 용적맥파는 광을 이용한 비 침습적 맥파 측정 방식으로 손가락 끝 부분에서 측정하고 혈액 내에 헤모글로빈의 빛에 대한 광 흡수도의 차이로 인해 나타나게 된다. 얻어진 신호를 2차 미분 하게 되면 가속도 맥파 (acceleration photoplethymogram, APG)를 얻을 수 있고 이는 혈관 탄성도의 추정에 응용가능하다. 본 연구에서는 혈관 탄성도를 측정하기 위한 방법으로 광전 용적맥파를 적용하여 가속도 맥파 측정기기를 설계하고, 이를 바탕으로 혈관 탄성도 추정에 적용 가능 여부를 연구하였다.

• 센서학회지
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• 제22권1호
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• pp.76-83
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• 2013

A real-time wireless monitoring and analysis methods using the wearable PPG sensor to estimate cardiovascular condition is studied for ubiquitous healthcare service. A small size and low-power consuming wearable photoplethysmogram (PPG) sensor is designed as a wrist type device and connected with the IP node assigned its own IPv6 address. The measured PPG waveform in the IP node is collected and transferred to a central server PC through the IP-enabled wireless network for storage and analysis purposes. A monitoring and analysis program is designed to process the accelerated plethysmogram (APG) waveform by applying the second order derivatives to analyze systolic waves as well as heart rate variability analysis from the measured PPG waveform. From our results, the features of cardiovascular condition from individual's PPG waveform and estimation of vascular compliance by the comparison of APG-aging index (AI) and ratio of LF/HF are demonstrated.

• 대한의용생체공학회:의공학회지
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• 제13권2호
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• pp.165-174
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• 1992

Compliance mismatch across an end-to-end anastomosis was measured In the In vitro experimental setup. A 35mm camera was used and Image process was done in Gould/ DeAnza Image processor. The results showed that compliances of Penrose tubing and synthetic PTFE grafts were In good agreement with the previously reported In vivo data. PTFE grafts exhibited a nonlinear behavior with compliance decreasing with Increasing transmural pressure, whereas the compliance of the Penrose tubing remained relatively constant within the range of the pressures in which data were obtained. The lumen cross sections at the anastomosis were affected by the suture and the mismatch In compliance between the Penrose tubing and vascular grafts. The varla~lons In the lumen dtameter at the anastomosis was more pronounced with increasing transmural pressures. From the present study, it was clearly demonstrated that the compliance of prosthetic grafts Is much lower than that of the arteries. In addition to the hemodynamlc consequences, compliance mismatch across the anastomosis has been known to lead to Increased anastomotlc and suture stresses with resultant suture line dehlscence and false aneurysm formation. Thus, there are good hemodynamic reasons to suppose that Introduction of a less compliant arterial graft Into the arterial circulation wlll be damaging and that grafts should be made to match the elastic behavior of their host arteries as closely possible.

• 대한의용생체공학회:의공학회지
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• 제30권2호
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• pp.129-134
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• 2009

The ideal method which measures a blood vessel of senility and degree of arteriosclerosis is to measure compliance of arterial and condition of blood circulation at the periphery. In these days vascular stiffness have been assessed by analyzing PTT (pulse transit time) from ECG and PPG. PTT is that between toe and finger each subject estimated through ECG and PPG signals. Two parameters, which are related to PWV, were tested with the time delay between the finger and toe. PWV is a variation of quantity which is associated with vascular stiffness. These researches which use PTT and PWV don't consider the blood vessel characteristic of an individual. In this current research, we have used with the blood vessel characteristic of an individual. That is an assessment of vascular stiffness using the variation of quantity in PWV with the changes of position in the subject. PWV variation increased as functions of the subject's age. The increase of the PWV variation parameters with age is attributed to the direct decrease of the blood vessel compliance with different position. The quantity of variation estimated by experimental results is that old age's (75.78${\pm}$7.75) case is 113.68% and young age's (26.47${\pm}$2.04) case is 85.69%. We proved and presented about estimation of vascular stiffness of possibility by this result.

• 디지털융복합연구
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• 제11권6호
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• pp.235-244
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• 2013

본 연구는 수중운동 참여가 정신지체장애인의 혈액성분 및 혈관탄성에 미치는 영향을 규명하기 위하여 수행되었다. 연구의 대상자는 교육 가능한 정신지체장애인 24명이었으며, 수중운동집단 12명, 통제집단 12명으로 무선배정하고 수중운동집단은 9주간 주 5회 1일 60분 실시하였다. 자료처리는 집단별 운동프로그램 참여 전, 후에 대한 평균치의 차이검증은 대응표본 t-test를 실시하였으며, 통계적 유의수준은 p<.05로 설정하여 다음과 같은 결론을 얻었다. 첫째, 수중운동 참여집단에서 체중 및 체지방률은 사후 유의한 감소를 나타냈다(p<.05). 둘째, 수중운동 참여집단에서 사후, Total-Cholesterol, Triglyceride, HDL-C, LDL-C은 유의한 감소와 증가를 나타냈다(p<.05). 셋째, 수중운동집단에서 혈관탄성은 사후, 상지 우, 좌, 하지 우, 좌는 사전과 비교하여 유의한 증가를 나타냈다(p<.05). 이상의 결과를 종합해 볼 때, 정신지체장애인을 대상으로 수중운동참여는 신체조성 및 혈액성분, 혈관탄성에 긍정적인 영향을 미치는 것으로 나타나 심혈관계질환 및 각종 합병증 발병률이 높은 정신지체장애인에게 바람직한 운동프로그램이 될 것으로 사료되며, 후속 연구에서는 정신지체장애인의 신체적 특성 및 개인의 체력수준에 알맞은 과학적이고 체계적인 운동프로그램을 모색하고 제시되어야 할 것으로 사료된다.

• 대한의용생체공학회:의공학회지
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• 제13권3호
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• pp.189-194
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• 1992

As people's income and intake of animal fat rapidly increase, so does choresterol concentration in blood. Thus diseases such as non-insulin-dependent diabetes mellitus(NIDDM)myocardial infraction, high blood pressure, cerebral stroke resulting from atherosclerosis rapidly increase recently. It is very difficult to diagnose atherosclerosis early since its progress is so slow and there is no sypmtoms in the beginning of the disease. In this study a mechanical characteristic, compliance, of the lower leg arteries was measured noninvasively. Changes of blood volume and pressure were measured using impedance plethysmgraphy and mercury sphygmomanometer, respectively. The compliance was calculated by dividing the change of blood volume by the change of pulse pressure ( systolic-diastolic pressure ) . Subjects were 24 asymptomatic persons ranging (rom 30 Ic 58yeras and 14 diabetics from 41 to 59years. The compliances, mean, and systolic pressures were statistically analyzed using a t-test be- tween the healthy and diabetic groups. The average compliance of the healthy and diabetic group was measured 2.79 and 1.82U1/mmHg/cm, respectively and these were significantly different(p<0.01). It was also found that the compliance is a better parameter in differentiating the vascular disease than mean or systolic blood pressure.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.250.1-250.1
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• 2003

Background Aldosterone has an important role in the pathophysiology of heart failure. Aldosterone promotes the retention of sodium, the loss of magnesium and potassium, sympathetic activation, parasympathetic inhibition, myocardial and vascular fibrosis, baroreceptor dysfunction, and vascular damage and impairs arterial compliance. Objectives We investigated the effects of additional spironolactone to angiotensin-converting enzyme inhibitor (ACEI) / angiotensin-II receptor blocker (ARB) in patients with heart failure. (omitted)

• 대한의용생체공학회:의공학회지
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• 제15권2호
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• pp.143-150
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• 1994

Wall shear rate or stress is believed to be a major hemodynamic variable influencing atherosclerosis and artery-graft anastomic intimal hyperplasia. The purpose of this study is to verify the effects of radial wall motion, artery-graft compliance and diameter mismatch, and impedance phase angle on the wall shear rate distribution near an end-to-end artery-graft anastomosis model. The results show that radial wall motion of the elastic artery model lowers the mean wall shear rates under pulsatile flow condition by 15 to 20 % comparing to those under steady flow condition at the same mean flow rate. Impedance phase angle seems to have small effects on the mean and amplitude of the wall shear rate distribution. In order to study the effects of compliance and diameter mismatch on the wall shear rates, two models are studied-Model I has 6% and Model I has 6% and Model II has 11% smaller graft diameter. Divergent geometry caused by diameter mismatch near the distal sites reduces the mean wall shear rates significantly, and this low shear region is believed to be prone to intimal hyperplasia.