• The Journal of Korean Physical Therapy
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• v.22 no.3
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• pp.71-77
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• 2010

Purpose: To determine whether upregulation of inducible nitric oxide synthase (iNOS) transcription and translation is related to radicular pain in a model of lumbar disc herniation. Also, to investigate the temporal changes of mRNA expression of iNOS and the identity of iNOS and transient receptor potential vanilloid (TRPV) 1 channel expression cells in dorsal root ganglion (DRG) of a model of lumbar disc herniation. Methods: A lumbar disc herniated rat model was developed by implantation of the autologous nucleus pulposus, harvested from the coccygeal vertebra of each tail, on the left L5 nerve root just proximal to the DRG. Rats were tested for mechanical allodynia of the plantar surface of both hind paws 2 days before surgery and 1, 5, 10, 20 and 30 days postoperatively. Reverse transcription polymerase chain reaction (RT-PCR) was used to follow iNOS mRNA expression. To stain iNOS and TRPV1 in DRG, an immunohistochemical study was done 10 days after surgery. Results: A significant drop in mechanical withdrawal threshold on the ipsilateral and contralateral hind paws was observed 1 day after surgery and was prolonged to 30 days in rats with lumbar disc herniation. The expression of mRNA for iNOS peaked at postoperative day 10 on both sides of the DRG. iNOS-positive sensory neurons in the DRG varied in size from large to small diameter cells. A majority of small and intermediate sensory neurons were TRPV1-positive cells. Double immunofluorescence staining for TRPV1 and iNOS revealed that most intermediate TRPV1-positive sensory neurons co-localized with iNOS-positive neurons. Conclusion: Nucleus pulposus-induced mechanical allodynia can be generated without mechanical compression. This pain is related to temporal changes in expression of iNOS mRNA in the DRG. Co-localization of TRPV1 and iNOS in intermediate neurons of the DRG is correlated with pain modality and intensity.

• Journal of the Korean Chemical Society
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• v.47 no.3
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• pp.250-256
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• 2003

In this work, the effect of cationic initiator content on the electron-beam (EB) curing process of diglycidylether of bisphenol-A (DGEBA) resin was studied using near-infrared spectroscopy (NIRS), thermogravimetric analysis (TGA), and critical stress intensity factor $(K_{IC})$. Benzylquinoxalinium hexafluoroantimonate (BQH) were used as an initiator and its content was varied from 0.5 to 3 phr. NIRS measurements showed that the hydroxyl group of EB-cured epoxy resin was increased with increasing the BQH content. Thermal stability and $K_{IC}$ value of EB-cured epoxy resin were increased with increasing the BQH content but were decreased above 2 phr content. These results could be attributed to the decrease of the conversion and degree of crosslinking. In another word, the conversion and degree of crosslinking were restricted by the incomplete network structure from high reactivity at the BQH content above 2 phr, resulting in decreasings of thermal stability and $K_{IC}$.

• Korean Journal of Ecology and Environment
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• v.35 no.1 s.97
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• pp.36-44
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• 2002

The spatial and temporal trends of water qualities in Lake Soyang was statistically analyzed in this study. The water qualities include nutrients, ionic contents and chlorophyll-a (Chl-a) measured during 1993${\sim}$2000. The rainfall intensity and runoff from the catchment appeared to play an important role in water quality trends in the lake. According to seasonal Mann-Kendall test, conductivity, TP, and Ctl-a did not show any trends of increase or decrease over the 8 year period, while TN declined slightly. It was found that the variation of TP was a function of interannual inflow and rainfall. In the analyses of spatial trend, conductivity, based on the mean by site, showed a downlake decline over the eight year period. Minimum conductivity was found in the headwaters during summer monsoon of July to August and near the dam during October. This result indicates a time-lag phenomenon that the headwater is diluted by rainwater immediately after summer monsoon rain and then the lake water near the dam is completely diluted in October. During summer period, TP and TN had an inverse relation with conductivity values. Concentrations of TP peaked during July to September in the headwaters and during September in the downlake. Also, TN increase during the summer and was more than 1.5 mg/L regardless of season and location, indicating a consistent eutrophic state. Values of Chl-a varied depending on location and season, but peaked in the midlake rather than in the headwaters during the monsoon. Regression analyses of log-transformed seasonal Chl-a against TP showed that value of $R^2$ was below 0.003 in the premonsoon and monsoon seasons but was 0.82 during the postmonsoon, indicating a greater algal response to the phosphorus during the postmonsoon. In contrast, TN had no any relations with Chl-a during all seasons.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.14
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• pp.5715-5719
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• 2015

Background: Breast cancer is the most common malignancy of women in the world. The disease is caused by infectious and non-infectious, environmental and lifestyle factors. Tobacco smoke has been one of the most widely studied environmental factors wiith possible relevance to breast cancer. The purpose of this study was to assess the impact of tobacco smoking in breast cancer patients in a hospital based cohort and to establish prognostic implications if any. Materials and Methods: A retrospective audit of 100 women with pathological diagnosis of invasive breast cancer was included in this study. The verbal questionnaire elicited information on current and previous history of exposure to smoking in addition to active smoking. All analyses were adjusted for potential confounders, including stage at presentation, alcohol intake, hormonal replacement therapy, oral contraceptive intake, obesity and menopausal status. Results: The mean age at presentation of breast cancer was $51.4{\pm}10.86$ years. Mean age of presentation was $53.1{\pm}11.5$ and $45.7{\pm}11.9$ years in never smokers and passive smokers, respectively. Age at presentation varied widely in patients exposed to tobacco smoke for >10 years in childhood from $40.3{\pm}12.0$ years to $47.7{\pm}13.9$ in patients exposed for > 20years as adults. Among passive smokers, 60.9% were premenopausal and 39.1% of patients were postmenopausal. In never smokers, 71.4% were post menopausal. Expression of receptors in non-smokers vs passive smokers was comparable with no significant differences. Metastatic potential in lung parenchyma was slightlyelevated in passive smokers as compared to never smokers although statistically non-significant. Conclusions: An inverse relationship exists between the intensity and duration of smoking and the age at presentation and poor prognostic factors. The results strongly suggest efforts should be taken to prevent smoking, encourage quitting and restrict exposure to second hand smoke in India.

• Journal of Korea Water Resources Association
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• v.30 no.1
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• pp.83-93
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• 1997

The purpose of the study is to analyze the sensitivity of the parameters that affect the runoff and water quality in the studied drainage basins. SWMM model is applied to the four drainage basins located at Namgazwa and Sanbon in Seoul and Gray Haven and Kings Creek in the USA. first of all, the optimum values of the parameters which have least simulation error to the observed data, are detected by iteration procedure. These are used as the standard values which are compared against the procedure. These are used as the standard values which are compared against the varied parameter values. In order to catch the effectiveness of the parameters to the computing result, the parameters are changed step by setp, and the results are compared to the standard results in flowerate and quality of the sewer. The study indicates that the discharge is greatly affected by the types of runoff surface, i.e., impervious area remarkably affects the peak flow and runoff volume while the surface storage affects the runoff volume at mild sloped basins. In addition, the major parameters affecting the pollution concentrations and loadings are the contaminant accumulation coefficient per unit area per time and the continuous dry weather days. Furthermore, the factors that affect the water quality during the initial rainfall period are the rainfall intensity, transport capacity coefficient and its power coefficient. Consequently, in order to simulate the runoff-water quality, it is needed to evaluate previous data in the research performed for the studied basins. To accurately estimated from the tributary areas and the rational computation methods of the pollutants calculation should be introduced.

• Proceedings of the Korea Water Resources Association Conference
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• 2011.05a
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• pp.18-18
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• 2011

Climate change is impacting and will increasingly impact both the quantity and quality of the world's water resources in a variety of ways. In some areas warming climate results in increased rainfall, surface runoff, and groundwater recharge while in others there may be declines in all of these. Water quality is described by a number of variables. Some are directly impacted by climate change. Temperature is an obvious example. Notably, increased atmospheric concentrations of $CO_2$ triggering climate change increase the $CO_2$ dissolving into water. This has manifold consequences including decreased pH and increased alkalinity, with resultant increases in dissolved concentrations of the minerals in geologic materials contacted by such water. Climate change is also expected to increase the number and intensity of extreme climate events, with related hydrologic changes. A simple framework has been developed in New Zealand for assessing and predicting climate change impacts on water resources. Assessment is largely based on trend analysis of historic data using the non-parametric Mann-Kendall method. Trend analysis requires long-term, regular monitoring data for both climate and hydrologic variables. Data quality is of primary importance and data gaps must be avoided. Quantitative prediction of climate change impacts on the quantity of water resources can be accomplished by computer modelling. This requires the serial coupling of various models. For example, regional downscaling of results from a world-wide general circulation model (GCM) can be used to forecast temperatures and precipitation for various emissions scenarios in specific catchments. Mechanistic or artificial intelligence modelling can then be used with these inputs to simulate climate change impacts over time, such as changes in streamflow, groundwater-surface water interactions, and changes in groundwater levels. The Waimea Plains catchment in New Zealand was selected for a test application of these assessment and prediction methods. This catchment is predicted to undergo relatively minor impacts due to climate change. All available climate and hydrologic databases were obtained and analyzed. These included climate (temperature, precipitation, solar radiation and sunshine hours, evapotranspiration, humidity, and cloud cover) and hydrologic (streamflow and quality and groundwater levels and quality) records. Results varied but there were indications of atmospheric temperature increasing, rainfall decreasing, streamflow decreasing, and groundwater level decreasing trends. Artificial intelligence modelling was applied to predict water usage, rainfall recharge of groundwater, and upstream flow for two regionally downscaled climate change scenarios (A1B and A2). The AI methods used were multi-layer perceptron (MLP) with extended Kalman filtering (EKF), genetic programming (GP), and a dynamic neuro-fuzzy local modelling system (DNFLMS), respectively. These were then used as inputs to a mechanistic groundwater flow-surface water interaction model (MODFLOW). A DNFLMS was also used to simulate downstream flow and groundwater levels for comparison with MODFLOW outputs. MODFLOW and DNFLMS outputs were consistent. They indicated declines in streamflow on the order of 21 to 23% for MODFLOW and DNFLMS (A1B scenario), respectively, and 27% in both cases for the A2 scenario under severe drought conditions by 2058-2059, with little if any change in groundwater levels.

• Journal of Korean Society of Forest Science
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• v.88 no.4
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• pp.477-484
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• 1999

This study was conducted to investigate the effect of forest road on the suspended sediment yield into a stream in the small forest watershed. The samples of suspended sediment yield were collected at surveying points A and B in mountains watersheds unaffected by forest road, and at surveying point C affected by forest road. When hourly change of suspended sediment concentration was investigated, it showed the highest increase along the forest road, and the peak of suspended sediment concentration due to the watershed characteristics of each surveying point occurred before or at the same time with, the peak of discharge. This may be due to the time lag in which stagnated unstable suspended sediment moved strongly upon rainfall. Although suspended sediment load varied depending upon rainfall factors and surveying period, suspended sediment load per unit watershed flowed out 4.1 times more at the point C than at the point A and B. The suspended sediment load on 18~19 September, 1998, strongly affected by rainfall factors, was 4.179g/sec/㏊ at the point C, and 0.343g/sec/㏊ and 0.147g/sec/㏊ at the point A and B, respectively. This load was 12 times higher at the point C than at the point A and 28 times higher than at the point B.

• Journal of Animal Science and Technology
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• v.45 no.3
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• pp.473-482
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• 2003

In vivo protective and in vitro inhibitory activities of Lactobacillus casei YIT 9018. against typical enteritis causing Salmonella enteritidis KU101 and IgA level after challenge have been determined. In order to identify the strains of lactobacilli the sequences of 16S-23S rRNA intergenic spacer region were determined. All the test strains of Lactobacillus spp. inhibited Salmonella enteritidis, the intensity varied depending upon the species of lactobacilli. Effects on the survival rate of the mouse after challenge with Salmonella enteritidis KU101 on feeding Lactobacillus spp. have shown the highest survival rate in L. helveticus CU 631 followed by L. casei YIT 9018 and L. johnsonii C-4 and the lowest in control mice. The higher level of total Ig A concentration in the intestinal fluid of lactobacilli fed mice than control mice was observed. The sequences of 16S-23S rRNA intergenic spacer region of seven strains of Lactobacillus casei could be utilized as a strain identification, those sequences showed some degree of difference in homology.

• Fire Science and Engineering
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• v.27 no.3
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• pp.1-7
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• 2013

The wildland fire intensity and scale are getting bigger owing to climate change in the world. In the case of domestic, the forest is distributed over approximately 63.7 % of country and the main facilities like a industrial facility or gas facility abuts onto it. Therefore there is potential that the wildland fire is developed to a large-scale disaster. In this study, the effect distances of the radiant heat flux from the crown fire are analysed according to the change of wind velocity. The safety criteria concerning the radiant heat flux to influence on the surrounding were researched to analyse the effect distances. The criteria of radiant heat flux were chosen $5kW/m^2$, $12.5kW/m^2$, $37.5kW/m^2$. WFDS, which is an extension of NIST's Fire Dynamics Simulator, was used to consequence analysis of the forest fire. In order to apply the analysis conditions, it is researched the forest conditions that is generally distributed in domestic region. As the result, the maximum effect distances by radiant heat were showed at the horizontal and vertical direction. When the wind velocity varied from 0 to 10 m/s, the maximum effect distance increased as the wind velocity increases. Interesting point is that the maximum effect distance were shown at the wind velocity of 8 m/s. The maximum effect distance was decreased according as the fuel moisture of trees increase. This study can contribute to analyse quantitative risk about the damage effect of the surrounding facilities caused by wildland fire.

• Economic and Environmental Geology
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• v.44 no.4
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• pp.289-302
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• 2011

Since the frequency of the earthquake occurrence in Korean peninsular is continuously increasing, the possibility that massive landslides are triggered by earthquake is also growing in Korea. Previously, the landslide is known to be induced by large magnitude earthquake, whose magnitude is larger than 6.0. However, the landslide can be induced by only small magnitude earthquake, especially in the fully saturated soil. Therefore, the susceptibility of landslide caused by small magnitude earthquake in fully saturated soil is analyzed in this study. For that, the topographical and geological characteristics of the site were obtained and managed by GIS software. In the procedure of the study, slope angle, cohesion, friction angle, unit weight of soil were obtained and constructed as a spatial database layer. Combining these data sets in a dynamic model based on Newmark's displacement analysis, the landslide displacements were estimated in each grid cell. In order to check out the possibility of the earthquake induced landslides, the level of the groundwater table is varied from dry to 80% saturated soil. In addition, in order to analyze the effect of the magnitude of earthquake and distance to epicenter, four different earthquakes epicenters were considered in the study area.