• 한국대기환경학회지
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• 제33권1호
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• pp.31-44
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• 2017

The aim of this study is to evaluate the accuracy and variability of the oak pollen concentrations over the Seoul metropolitan region (SMR) simulated by the Community Multiscale Air Quality (CMAQ)-based pollen dispersion model, which is the CMAQ-pollen model integrated with the improved oak pollen emission model(PEM-oak). The PEM-oak model developed is based on hourly emission flux parameterization that includes the effects of plant-specific release, meteorological adjustment, and diurnal variations of oak pollen concentrations. A 33 day-run for oak pollen simulation was conducted by the CMAQ-pollen model with a 3 km spatial resolution for the SMR during the 2014 spring pollen season. Modeled concentrations were evaluated against the hourly measurements at three Burkard sampling sites. Temporal variations of oak concentrations were largely well represented by the model, but the quantitative difference between simulations and measurements was found to be significant in some periods. The model results also showed that large variations in oak pollen concentrations existed in time and space and high concentrations in the SMR were closely associated with the regional transport under strong wind condition. This study showed the effective application of the CMAQ-pollen modeling system to simulate oak pollen concentration in the SMR. Our results could be helpful in providing information on allergenic pollen exposure. Further efforts are needed to further understand the oak pollen release characteristics such as interannual variation of the oak pollen productivity and its spatio-temporal flowering timing.

• 디지털융복합연구
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• 제13권8호
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• pp.419-429
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• 2015

본 연구는 고지혈증 유병률의 지역 간 변이 정도와 위험 요인을 규명하여 지역별 특성에 맞는 고지혈증 관리 사업을 지원하기 위한 기초자료를 제공하기 위해 수행되었다. 이를 위해 질병관리본부의 2012년도 시군구 지역사회건강조사 249건의 자료를 이용하여 단순 상관관계 분석, 단계적 회귀분석, 의사결정나무 등의 기법으로 분석하였다. 249개 시군구 지역의 고지혈증 유병률은 9.2%였고, 변동계수는 28.3%였다. 남동부 해안지역에 비해 수도권과 내륙지방의 고지혈증 유병률이 높았다. 의사결정나무 모형이 회귀모형에 비해 예측력이 좋았는데, 지역의 임금근로자 비율, 스트레스 인지율, 고혈압, 협심증, 관절염 유병률이 높은 지역일수록 고지혈증 유병률이 높은 것으로 나타났다. 따라서 사회 역학적 관점에서 지역사회의 개입이 가능한 지점을 중심으로 고지혈증 유병률을 감소시키기 위한 전략 마련이 필요하다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7555-7560
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• 2013

Background: Beedi rollers are exposed to unburnt tobacco dust through cutaneous and pharyngeal route and it is extremely harmful to the body since it is carcinogenic in nature and can cause cancer during long exposure. This indicates that occupational exposure to tobacco imposes considerable genotoxicity among beedi workers. Materials and Methods: In the present study, 27 beedi workers and age and sex matched controls were enrolled for clinical, cytogenetics and molecular analysis. Clinical features were recorded. The workers were in the age group of 28-67 years and were workers exposure from 8-60 years. Blood samples were collected from workers and control subjects and lymphocyte cultures were carried out by using standard technique, slides were prepared and 50 metaphases were scored for each sample to find the chromosomal abnormalities. For molecular analysis the genomic DNA was extracted from peripheral blood, to screen the variations in gene, the exon 1 of CYP1A1 gene was amplified by polymerase chain reaction (PCR) and then screened with Single Strand Conformation Polymorphism (SSCP) analysis. Results: A statistically significant increase was observed in the frequencies of chromosomal aberrations in exposed groups when compared to the respective controls and variations observed in Exon 1 of CYP1A1(Cytochrome P450, family 1, subfamily A, polypeptide 1) gene. Conclusions: This study shows that, the toxicants present in the beedi that enter into human body causes disturbance to normal state and behavior of the chromosomes which results in reshuffling of hereditary material causing chromosomal aberrations and genomic variations.

• 한국대기환경학회지
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• 제17권6호
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• pp.451-461
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• 2001

Backward trajectories were calculated from five urban areas in Korea in 1999 in order to assess the effects of long-range transport on the air quality variations on an annual basis. The five areas selected were Seoul, Mokpo, Cheju, Pohang, and Kangnung, which are evenly distributed along the shoreline in Korea. Meteorological fields used in the work were prepared by the Korea Meteorological Administration using the RDAPS(Regional Data Assimilation and Prediction System) with grid spacing of 40 km and 12-h intervals(0000 and 1200 UTC). Upwind regions around the Korean Peninsula were divided into five sectors including the region to the northeast(I), northern China (II), southern China(III), the northwestern Pacific(IV), and Japan(V). The influence of air flow from these sectors on the variations of carbon monoxide concentrations in the selected areas was investigated. The results showed that the influences of Sectors II and III were persistent although some influences of adjacent sectors were observed according to the location of the areas. In general, the concentration of carbon monoxide tended to go up under the influence of Sectors II and III but tended to go down under the influence of Sector I. However, the influences of other sectors were rather mixed. The importance of the long-range transport was examined when the whole country was uniformly influenced by Sectors II and III with strong synoptic winds. The effects of long-range transport were large in Mokpo and Cheju, close to Sectors II and III, where the local emissions were considered small. The effects of local emissions were significant in Pohang and Seoul; such effect was more distinct in Pohang located farther from Sectors II and III.

• 한국전산유체공학회지
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• 제9권4호
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• pp.34-40
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• 2004

It is known that the non-planar model of bypass is more profitable to suppress the development of intimal hyperplasia that tends to occur preferentially in regions of low time averaged shear stress and rapid temporal changes in wall shear stress. In this study it was numerically simulated the blood flow in an coronary artery grafted by artificial bypass to determine the flow characteristic variations due to the anastomosis angle changing. 5 different non-planar anastomosis angle models such as 45°, 60°, 90°, 120° and 135° were considered. When the anastomosis angle is higher, the backward flow region is spatially extended near the downstream region of the anastomosis because of the development of horseshoes vortex. For the case of the nan-planar 45° and 60° of anastomosis, the area of low-OSI zone was decreased by 26% and 13% respectively and the time averaged wall shear stress was increased by more than 55% as compared with 45° of planar model. However, both of the area of the low-OSI zone and the time averaged wall shear stress of 90°, 120° model were significantly increased.

• 디지털융복합연구
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• 제10권3호
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• pp.207-218
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• 2012

본 연구는 심질환을 대상으로 지역간 입원의료이용의 변이정도와 양상을 파악하고, 변이 발생에 영향을 미치는 요인을 분석한 후 이를 개선하기 위한 정책방안을 도출하기 위해 수행하였다. 2008년도 환자조사와 국민건강보험공단 자료 및 지역사회건강조사 자료를 이용하여 전국을 160개 진료권으로 세분화 한 후 심질환 입원환자의 성 연령 표준화 입원율과 l인당 재원일수를 산출하는 한편, 이에 영향을 미치는 요인을 분석하였다. 연구 결과, 진료권으로 구분한 소규모 지역별로 성 연령 표준화 입원율과 1인당 재원일수에서 변이가 큰 것으로 나타났다. 그리고 지역간 표준화 입원율의 변이에 유의한 영향을 미치는 변수로는 인구만명당 특수의료장비수와 중등도이상 신체활동 실천율로 분석되었고, 표준화 1인당 재원일수의 변이에는 인구만명당 병상수, 특수의료장비수 및 현재흡연율이 통계적으로 유의한 영향을 미치는 변수로 나타났다. 정책적 시사점으로는 심질환자의 지역간 입원의료이용변이가 높은 만큼 지역별 의료자원공급의 효율적인 배분을 포함한 다각적인 정책적 개입과 더불어 환자 측면에서 의료이용을 합리적으로 유도할 수 있도록 제도적 보완책이 강구되어야 할 것이다.

• Asian-Australasian Journal of Animal Sciences
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• 제26권4호
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• pp.483-487
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• 2013

The peroxisome proliferator-activated receptor gamma coactivator-1 alpha protein, encoded by the PPARGC1A gene, plays an important role in energy homeostasis. The genetic variations within the PPARGC1A gene promoter region were scanned in 808 Chinese native bovines belonging to three cattle breeds and yaks. A total of 6 SNPs and one 4 bp insertion variation in the promoter region of the bovine PPARGC1A gene were identified: SNP -259 T>A, -301_-298insCTTT, -915 A>G, -1175 T>G, -1590 C>T, -1665 C>T and -1690 G>A, which are in the binding sites of some important transcription factors: sex-determining region Y (SRY), myeloid-specific zinc finger-1 (MZF-1) and octamer factor 1(Oct-1). It is expected that these polymorphisms may regulate PPARGC1A gene transcription and might have consequences at a regulatory level.

• Mycobiology
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• 제37권3호
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• pp.183-188
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• 2009

The molecular phylogeny in nine different commercial cultivated strains of Pleurotus nebrodensis was studied based on their internal transcribed spacer (ITS) region and RAPD. In the sequence of ITS region of selected strains, it was revealed that the total length ranged from 592 to 614 bp. The size of ITS1 and ITS2 regions varied among the strains from 219 to 228 bp and 211 to 229 bp, respectively. The sequence of ITS2 was more variable than ITS1 and the region of 5.8S sequences were identical. Phylogenetic tree of the ITS region sequences indicated that selected strains were classified into five clusters. The reciprocal homologies of the ITS region sequences ranged from 99 to 100%. The strains were also analyzed by RAPD with 20 arbitrary primers. Twelve primers were efficient to applying amplification of the genomic DNA. The sizes of the polymorphic fragments obtained were in the range of 200 to 2000 bp. RAPD and ITS analysis techniques were able to detect genetic variation among the tested strains. Experimental results suggested that IUM-1381, IUM-3914, IUM-1495 and AY-581431 strains were genetically very similar. Therefore, all IUM and NCBI gene bank strains of P. nebrodensis were genetically same with some variations.

• 한국동물위생학회지
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• 제34권2호
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• pp.103-109
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• 2011

Asia1/Shamir that has been recommended by World Reference Laboratory for foot-and-mouth disease (FMD) is used as a vaccine strain, and is being prepared in many countries including Korea. Although it is assumed that vaccine strain Asia1/Shamir has a wide antigenicity, sufficient molecular biological analysis has not been accomplished yet. Complete genome sequence analysis showed that the region with the most severe variations was 1D region of structural protein-coding sequence; particularly amino acid 141~157 residues in 1D region RGD sites for binding to susceptible cells. In addition, five amino acids in 1D region were identified as characteristic sites that are different from other known Asia1 viruses. Asia1/Shamir strain was shown to be genetically similar to group VI that had occurred in the Middle East, but showed low level of genetic similarity to the group V viruses that had occurred in the Southeast Asia and China. It is considered that, if these viruses, group I and II including group V are introduced into Korea, care would be paid in case of inoculating the vaccine strain Shamir available in Korea.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.599-606
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• 2012

The characterization of the whole genome of human papillomavirus type 16 (HPV16) from cervical cancer specimens with multiple infections in comparison with single infection samples as the oncogenic potential of the virus may differ. Cervical carcinoma specimens positive for HPV16 by PCR and INNO-LiPA were randomly selected for whole genome characterization. Two HPV16 single infection and six HPV16 multiple infection specimens were subjected to whole genome analysis by using conserved primers and subsequent sequencing. All HPV16 whole genomes from single infection samples clustered in the European (E) lineage while all multiple infection specimens belonged to the non-European lineage. The variations in nucleotide sequences in E6, E7, E2, L1 and Long control region (LCR) were evaluated. In the E6 region, amino acid changes at L83V were related to increased cancer progression. An amino acid variation N29S within the E7 oncoprotein significantly associated with severity of lesion was also discovered. In all three domains of the E2 gene non synonymous mutations were found. The L1 region showed various mutations which may be related to conformation changes of viral epitopes. Some transcription factor binding sites in the LCR region correlated to virulence were shown on GRE/1, TEF-1, YY14 and Oct-1. HPV16 European variant prone to single infection may harbor a major variation at L83V which significantly increases the risk for developing cervical carcinoma. HPV16 non-European variants prone to multiple infections may require many polymorphisms to enhance the risk of cervical cancer development.