• Journal of Microbiology and Biotechnology
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• 제26권3호
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• pp.588-595
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• 2016

IFN-γ release assays (IGRAs) have been developed as viable alternative diagnostic tools for detecting latent tuberculosis infection (LTBI). A customized homogeneous sandwich luminescent oxygen channeling immunoassay (LOCI) was used to quantify IFN-γ levels in IGRAs. Samples were collected from healthy volunteers (n = 40) who were T-Spot-negative and T-Spot-positive patients (n = 32) at rest. Then the amount of IFN-γ in the supernatant of IGRAs was measured by LOCI. The results demonstrated a low background, and high sensitivity, specificity, accuracy, and reproducibility, and a short assay time (only 30 min) with LOCI for IFN-γ. The recovery range was 81.63-102.06%, the coefficients of variation were below 5%, and the limit of detection was 19.0 mIU/ml. Excellent agreement between LOCI IFN-γ and the T-SPOT.TB test was obtained (97.2% agreement, κ = 0.94). The LOCI IFN-γ concentrations were significantly higher in T-Spot-positive patients than in the healthy group (p < 0.001). Moreover, as observed for the comparative LOCI IFN-γ assay, IFN-γ concentrations were related to the numbers of T-SPOT.TB spots. We have established an in vitro blood test for LTBI diagnosis, defined as LOCI IFN-γ. A high level of agreement between the LOCI IFN-γ method and T-SPOT.TB assay was observed in clinical studies that showed the LOCI IFN-γ method could determine LTBI. This study shows acceptable performance characteristics of the LOCI IFN-γ assay to diagnose LTBI.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제17권4호
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• pp.415-428
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• 1995

The author studied on the 115 cases of the ameloblastoma which had been diagnosed with biopsy during the period of 1962 to 1994 at the Kyungpook National University Hospital, Pusan National University Hospital, Youngnam University Hospital, Keimyung University Hospital, Catholic Medical School Hospital, and Maryknol Hospital. This study contains the statistical analysis of the clinico-pathological findings such as sex, age, location, chief complaint, duration,treatment method, size, recurrence and impacted teeth in relation to radiographic findings. The results were as follows : 1. The incidence rate was 60% in male and 40% in female. 2. At the time of diagnosis, the age of the patients ranged from 9 to 69 years old (average 31.4 years old). The cases of 73% were in the 2nd, 3rd and 4th decades of life. 3. The majority of cases, 88.7% occurred in the mandible, especially 59% in the mandibular angle area. 4. The most prevalent chief complaint of swelling was 56.5%. 5. As regards duration, the cases less than 12 months appeared 49.5%, and average duration is 30.45months. 6. Unilocular radiographic findings showed 43.5%, Multilocular radiographic findings appeared 56.5%. 7. Conservative treatment was performed 40.0%, and radical treatment was employed 60.0%. 8. There was the variation of lesional sizes between 2.0cm and 15cm, average size 6.19cm. 9. Recurrent cases were 28.7%, and impacted teeth were shown 30.43%. 10. The radiographic finding has no relationship with the factors of age, location, chief complaint, recurrence and impacted teeth, however there is slight indication that the below 30-year-old patient tend to be related to the multilocular type. 11. The multilocular radiographic findings were shown more frequently in the groups of females, over average of 30.45 months, over average size of 6.19cm and radical treatment.

• 인터넷정보학회논문지
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• 제21권2호
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• pp.19-26
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• 2020

This paper analyses the feasibility of using implantable antennas to detect and monitor tumors. We analyze this setting according to the wireless propagation loss and signal fading produced by human bodies and their environment in an indoor scenario. The study is based on the ITU-R propagation recommendations and prediction models for the planning of indoor radio communication systems and radio local area networks in the frequency range of 300 MHz to 100 GHz. We conduct primary estimations on 915 MHz and 2.4 GHz operating frequencies. The path loss presented in most short-range wireless implant devices does not take into account the human body as a channel itself, which causes additional losses to wireless designs. In this paper, we examine the propagation through the human body, including losses taken from bones, muscles, fat, and clothes, which results in a more accurate characterization and estimation of the channel. The results obtained from our simulation indicates a variation of the return loss of the spiral antenna when a tumor is located near the implant. This knowledge can be applied in medical detection, and monitoring of early tumors, by analyzing the electromagnetic field behavior of the implant. The tumor was modeled under CST Microwave Studio, using Wisconsin Diagnosis Breast Cancer Dataset. Features like the radius, texture, perimeter, area, and smoothness of the tumor are included along with their label data to determine whether the external shape has malignant or benign physiognomies. An explanation of the feasibility of the system deployment and technical recommendations to avoid interference is also described.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1389-1393
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• 2012

Objective: To discuss the significance of DOG1, CD117 and PDGFRA in the diagnosis of gastrointestinal stromal tumors (GISTs), and analyze their correlations with clinicopathological features and risk ranking. Method: DOG1, CD117 and PDGFRA were detected with IHC Envision ldpe-g-nvp in 63 GISTs and 43 cases of non-GISTs, and analyzed for relations with clinicopathological factors (gender, age, location, tumor size, mitotic phase, histology) and risk degree. Results: The positive expression rate of DOG1, CD117 and PDGFRA in GISTs was 84.1% (53/63), 90.5% (57/63), 53.2% (33/63), respectively. Among the 6 CD117 negative cases, all were DOG1 positive and 5 were PDGFRA positive. Rates in patients with non-GISTs was 11.6%, 16.3%, 6.98%, respectively. Expression of DOG1 and PDGFRA demonstrated no significant variation with gender, age, position, tumor size, mitotic phase, histology, and risk rank. However, CD117 was related with position and histology (P=0.008 and P=0.045), those in the mesentery having a higher positive rate than those derived from stomach, small intestine, colon and rectum (50.0% vs 94.7%, P=0.008). Furthermore CD117 was also highly expressed in spindle and epithele types. Conclusions: DOG1 had a good sensitivity and specificity as a kind of newly discovered marker, especially for KIT negative GISTs. However, DOG1, CD117 and PDGFRA cannot be used for assessing the rish of patients.

• Nuclear Engineering and Technology
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• 제47권2호
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• pp.204-211
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• 2015

Probabilistic safety assessment (PSA) has had a significant role in quantitative decision-making by finding design and operational vulnerabilities and evaluating cost-benefit in improving such weak points. In particular, it has been widely used as the core methodology for risk-informed applications (RIAs). Even though the nature of PSA seeks realistic results, there are still "conservative" aspects. One of the sources for the conservatism is the assumptions of safety analysis and the estimation of failure frequency. Surveillance, diagnosis, and prognosis (SDP), utilizing massive databases and information technology, is worth highlighting in terms of its capability for alleviating the conservatism in conventional PSA. This article provides enabling techniques to solidify a method to provide time- and condition-dependent risks by integrating a conventional PSA model with condition monitoring and prognostics techniques. We will discuss how to integrate the results with frequency of initiating events (IEs) and probability of basic events (BEs). Two illustrative examples will be introduced: (1) how the failure probability of a passive system can be evaluated under different plant conditions and (2) how the IE frequency for a steam generator tube rupture (SGTR) can be updated in terms of operating time. We expect that the proposed model can take a role of annunciator to show the variation of core damage frequency (CDF) depending on operational conditions.

• 대한치과보철학회지
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• 제33권4호
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• pp.769-779
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• 1995

The understanding the nature of occlusal tooth contacts of natural dentition is important for correct diagnosis and treatment of diseases developed in stomatognatic system. Several investigator have studied the distribution of tooth contacts in maximum intercuspation and have repored contact locations with respect to the tooth position. However, there are few report the variation of the occlusal contact point with change in each head position. This study analysed the number of occlusal contact point with change in each head position. 30 subject(male 17, female 13), who ahad natural occlusion and no symptoms of temporomandibular disorder, were selected. The numbers and patterns of tooth contact were recorded by silicone bite registration on stone model at four different head positions with head anguration gauge(from the supine to the upright position). The results obtained were as follows : 1. The numbers of total occlusal contact point on teeth increased to average 25, 29, 35, 42 points as head angulation was changed from the supine to the upright position against the ala-tragus line, and there was significant difference(P<0.05). 2. In the 19 subject(65%)of total 30 subject, the perforated point of the silicone bite indicated that the locus for the prime contact point moved mesially as the head angulation was changed from the supine to the upright position. 3. On the basis of the fact that the anterior occlusal contact point increase as head angulation changed from the supine to the upright position, we could find that the mandibular position is moved anteriorly.

• Imaging Science in Dentistry
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• 제48권1호
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• pp.45-49
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• 2018

Purpose: The aim of this study was to evaluate the quantitative strain elastography of tongue carcinoma using intraoral ultrasonography. Materials and Methods: Two patients with squamous cell carcinoma (SCC) who underwent quantitative strain elastography for the diagnosis of tongue lesions using intraoral ultrasonography were included in this prospective study. Strain elastography was performed using a linear 14 MHz transducer (Aplio 300; Canon Medical Systems, Otawara, Japan). Manual light compression and decompression of the tongue by the transducer was performed to achieve optimal and consistent color coding. The variation in tissue strain over time caused by the compression exerted using the probe was displayed as a strain graph. The integrated strain elastography software allowed the operator to place circular regions of interest (ROIs) of various diameters within the elastography window, and automatically displayed quantitative strain (%) for each ROI. Quantitative indices of the strain (%) were measured for normal tissues and lesions in the tongue. Results: The average strain of normal tissue and tongue SCC in a 50-year-old man was 1.468% and 0.000%, respectively. The average strain of normal tissue and tongue SCC in a 59-year-old man was 1.007% and 0.000%, respectively. Conclusion: We investigated the quantitative strain elastography of tongue carcinoma using intraoral ultrasonography. Strain elastography using intraoral ultrasonography is a promising technique for characterizing and differentiating normal tissues and SCC in the tongue.

• Journal of Magnetics
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• 제22권1호
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• pp.55-59
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• 2017

The purpose of this study was to quantitatively evaluate image quality using intensity profile, coefficient of variation (COV), and peak signal to noise ratio (PSNR) with respect to noise reduction techniques in the ultrasound images. For that purpose, we compared with the median filter, Rudin-Osher-Fatemi (ROF), Anscombe and proposed patch group prior based denoising (PGPD) techniques. To evaluate image quality, the Shepp-Logan phantom and the ultrasound image were acquired using simulation and experiment, respectively. According to the results, the difference of intensity profile using PGPD technique is lowest compared with original Shepp-Logan phantom. In simulation, the measured COV was 0.249, 0.198, 0.198, 0.177, and 0.080 using noisy, median, ROF, Anscombe and PGPD technique, respectively. Also, in experimental image, the measured COV was 0.245, 0.230, 0.231, 0.242 and 0.187 using noisy, median, ROF, Anscombe and PGPD technique, respectively. Especially, when we used PGPD technique, the PSNR has highest value in both simulation and experiment. In this study, we performed simulation and experiment study to compare various denoising techniques in the ultrasound image. We can expect the PGPD technique to improve in medical diagnosis with excellent noise reduction.

• Journal of Power Electronics
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• 제17권4호
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• pp.972-982
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• 2017

The Park's vector of stator current is a popular technique for the detection of induction motor faults. While the detection of the faulty condition using the Park's vector technique is easy, the classification of different types of faults is intricate. This problem is overcome by the Multiple Park's Vector (MPV) approach proposed in this paper. In this technique, the characteristic fault frequency component (CFFC) of stator winding faults, rotor winding faults, unbalanced voltage and bearing faults are extracted from three phase stator currents. Due to constructional asymmetry, under the healthy condition these characteristic fault frequency components are unbalanced. In order to balanced them, a correction factor is added to the characteristic fault frequency components of three phase stator currents. Therefore, the Park's vector pattern under the healthy condition is circular in shape. This pattern is considered as a reference pattern under the healthy condition. According to the fault condition, the amplitude and phase of characteristic faults frequency components changes. Thus, the pattern of the Park's vector changes. By monitoring the variation in multiple Park's vector patterns, the type of fault and its severity level is identified. In the proposed technique, the diagnosis of faults is immune to the effects of unbalanced voltage and multiple faults. This technique is verified on a 7.5 hp three phase wound rotor induction motor (WRIM). The experimental analysis is verified by simulation results.

• Parasites, Hosts and Diseases
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• 제35권3호
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• pp.197-202
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• 1997

고양이 4마리의 폐흡충 피낭유충을 50마리씩 감염시키고, 1주부터 13주까지 감염단계별 혈청을 채취하고 폐흡충 충란, 피낭유충, 4주, 7주 및 16주 충체 추출물 항원에 대한 항체 반응을 관찰하였다. 초기 항채 반응은 감염 3주 후부터 관찰되었다. 항원별로는 4주 충체 항원에 대한 항체가가 가장 먼저, 높게 증가하였고, 7주, 16주 충체 항원에 대한 반응이 그 다음으로 높았다. 충란 항원에 대한 항체 반응은 10주 이후 증가하였다. 피낭유충 충체 항원에 대한 반응은 관찰한 초기 감염 전체 기간에 걸쳐 비교적 낮았다. Immunoblot을 실시한 결과, 충란 항원 특이 28, 46, 94 kDa 항원대에 대한 반응은 10주 이후부터 관찰할 수 있었다. 4주 충체 항원은 10-25, 29, 31 kDa 등이 감염 초기부터 항원성을 나타내고 있었고, 그 중에는 감염 13주 혈청에 대하여 이미 반응이 약하게 된 항원대도 있었고 다른 기생충 질환 혈청과 교차반응을 나타내는 것이 알려진 항원도 있었다. 16주 성충 충체 항원의 32, 35 kDa 항원대는 감연 4주 후부터 특이한 반응을 나타내고 있었다. 이상의 결과, 감염 경과에 따라 폐흡충 항원단백질의 항원 결정기도 성충의 것으로 바뀌는 것을 알 수 있었고 성충 충체항원의 32 및 35 kDa 단백질은 4주 이후 초기 폐흡충증도 진단할 수 있는 항원 성분으로 생각하였다.